INT58439

Context Info Confidence 0.42 First Reported 1993 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 5 Disease Relevance 0.88 Pain Relevance 0.39

signal transduction (Gnat3) GTPase activity (Gnat3) cytoplasm (Gnat3) signal transducer activity (Gnat3)

Anatomy Link Frequency coronary artery 2 Gnat3 (Mus musculus)

Pain Link Frequency Relevance Heat Angina 7 100.00 Bioavailability 8 92.96 tolerance 34 44.20 Glutamate 4 31.56 addiction 10 5.00 Potency 4 5.00 ischemia 2 5.00 alcohol 2 5.00

Disease Link Frequency Relevance Heat Coronary Artery Disease 4 100.00 Angina 3 100.00 Increased Venous Pressure Under Development 8 94.72 Hypertension 5 86.80 Complex Regional Pain Syndromes 1 72.56 Cv General 3 Under Development 3 71.56 Myocardial Infarction 1 70.72 Targeted Disruption 2 5.00 Stress 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

After administration of GTN, SBP was decreased significantly from 157 +/- 25 to 142 +/- 23 mmHg (P < 0.01), while DBP did not change (83 +/- 13 vs 84 +/- 15 mmHg).

Negative_regulation (decreased) of Gene_expression (administration) of GTN

1) Confidence 0.42 Published 1993 Journal Angiology Section Abstract Doc Link 8285372 Disease Relevance 0.59 Pain Relevance 0.22

Importantly, ALDH2-catalyzed GTN reduction was partly inactivated by preincubation with GTN, suggesting that the inactivation of GTN reduction is also partly irreversible.

Negative_regulation (inactivation) of Gene_expression (reduction) of GTN

2) Confidence 0.21 Published 2008 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2576553 Disease Relevance 0 Pain Relevance 0

SCHEME 1.Irreversible inactivation of ALDH-catalyzed GTN reduction.

Negative_regulation (inactivation) of Gene_expression (reduction) of GTN

3) Confidence 0.18 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576553 Disease Relevance 0 Pain Relevance 0

Under these conditions, the effect of ALDH2/GTN even exceeded that of 10 ?

Negative_regulation (exceeded) of Gene_expression (effect) of GTN

4) Confidence 0.11 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0 Pain Relevance 0.05

Another study reported that the efficacious rate of sublingual GTN, measured as reduction of ischemic chest pain of patients having documented coronary artery disease, was reduced from 85.1% in controls to 57.6% in subjects carrying at least one ALDH2*2 allele (24).

Negative_regulation (reduced) of Gene_expression (rate) of GTN in coronary artery associated with angina and coronary artery disease

5) Confidence 0.10 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0.29 Pain Relevance 0.13

General Comments

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