INT58449

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Context Info
Confidence 0.47
First Reported 1993
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 47
Total Number 47
Disease Relevance 22.02
Pain Relevance 10.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mthfd1) oxidoreductase activity (Mthfd1) ligase activity (Mthfd1)
cytoplasm (Mthfd1)
Anatomy Link Frequency
T cells 9
macrophages 6
skin 2
lamina 2
Lung 2
Mthfd1 (Mus musculus)
Pain Link Frequency Relevance Heat
unmyelinated 15 100.00 Very High Very High Very High
chemokine 230 99.84 Very High Very High Very High
Inflammation 655 99.72 Very High Very High Very High
substance P 221 99.62 Very High Very High Very High
rheumatoid arthritis 283 99.60 Very High Very High Very High
cytokine 456 99.40 Very High Very High Very High
aspirin 41 99.10 Very High Very High Very High
antagonist 57 98.92 Very High Very High Very High
Inflammatory response 51 98.92 Very High Very High Very High
Calcitonin gene-related peptide 75 94.80 High High
Disease Link Frequency Relevance Heat
Stress 74 99.98 Very High Very High Very High
Candida Infection 274 99.92 Very High Very High Very High
Inflammatory Bowel Disease 69 99.92 Very High Very High Very High
Synovitis 60 99.80 Very High Very High Very High
Rheumatoid Arthritis 285 99.60 Very High Very High Very High
Multiple Sclerosis 65 99.60 Very High Very High Very High
INFLAMMATION 686 99.40 Very High Very High Very High
Asthma 41 99.00 Very High Very High Very High
Benign Prostatic Hypertrophy 2 98.80 Very High Very High Very High
Disease 331 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, E. coli K1 also interacts with DCs to suppress both maturation and antigen presentation (Mittal and Prasadarao, 2008).
DCs Binding (interacts) of
1) Confidence 0.47 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2882833 Disease Relevance 0.77 Pain Relevance 0.07
Evaluation of antigen-presenting activity of BMDCs
DCs Binding (activity) of
2) Confidence 0.36 Published 2009 Journal Respir Res Section Body Doc Link PMC2731726 Disease Relevance 0.38 Pain Relevance 0
Surface Tlr2 on DCs and macrophages also bind virus glycoproteins and result in production of pro-inflammatory response [4].
DCs Binding (bind) of in macrophages associated with inflammatory response
3) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 1.38 Pain Relevance 0.18
These events allowed us to test two hypotheses: a) alterations in C3a or C5a levels during compression are related to the occurrence of HPNS and b) increases in complement fragments are an indicator of decompression stress associated with type I DCS.
DCS Binding (associated) of associated with stress and high-pressure neurological syndrome
4) Confidence 0.30 Published 1993 Journal Undersea Hyperb Med Section Abstract Doc Link 8286982 Disease Relevance 0.56 Pain Relevance 0.09
HSPs have been shown to interact with a number of receptors present on the surface of DCs and promote their maturation[24].
DCs Binding (interact) of
5) Confidence 0.25 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.70 Pain Relevance 0
The infiltrated DCs were mostly recruited to the periphery of thermal lesions after hifu exposure
DCs Binding (recruited) of
6) Confidence 0.23 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.72 Pain Relevance 0
Next, DCs migrate to the lymph nodes where they present the antigen on MHC molecules, and the process culminates with activation of reactive T cells.
DCs Binding (migrate) of in T cells
7) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811739 Disease Relevance 0.56 Pain Relevance 0.15
Cognate T cell interactions with antigen-bearing DCs seem to last significantly longer: stably interacting CD4+ T cells and DCs (more than 1 hour and up to 15 hours), preceding T cell activation, were first described in the superficial area of explanted lymph nodes by Stoll and colleagues [19] using confocal microscopy.
DCs Binding (interactions) of in T cell
8) Confidence 0.19 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297591 Disease Relevance 0 Pain Relevance 0
A similar high concentration of interacting T cells and DCs was observed in the interfollicular region ('cortical ridge').
DCs Binding (interacting) of in ridge
9) Confidence 0.19 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297591 Disease Relevance 0 Pain Relevance 0
Cognate T cell interactions with antigen-bearing DCs seem to last significantly longer: stably interacting CD4+ T cells and DCs (more than 1 hour and up to 15 hours), preceding T cell activation, were first described in the superficial area of explanted lymph nodes by Stoll and colleagues [19] using confocal microscopy.
DCs Binding (interactions) of in T cell
10) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297591 Disease Relevance 0 Pain Relevance 0
Nevertheless, this question gains considerable importance as soon as antigen-specific T cells are supposed to interact with antigen-bearing DCs.
DCs Binding (interact) of in T cells
11) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297591 Disease Relevance 0 Pain Relevance 0.24
2, the null cells appear larger, lack long membrane elongations that DCs form to interact with T cells, and present abnormal podosome structures, characterized by condensed actin dots not surrounded by the typical ring of vinculin.
DCs Binding (interact) of in T cells
12) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811739 Disease Relevance 0.11 Pain Relevance 0.15
Importantly, we confirmed the in vivo role of the NK1 receptor in CS-induced recruitment of macrophages and DCs by using the NK1 receptor antagonist RP 67580.
DCs Binding (recruitment) of in macrophages associated with antagonist
13) Confidence 0.15 Published 2009 Journal Respir Res Section Body Doc Link PMC2689186 Disease Relevance 0.47 Pain Relevance 0.12
These findings confirm that in vitro, surface vimentin is present on unactivated DCs, which are able to bind and internalize CPMV.
DCs Binding (bind) of
14) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776531 Disease Relevance 0 Pain Relevance 0
Although centripetal migration of DCs from the limboconjunctiva to the cornea is known to play a critical role in promoting chronic immune inflammation in models of corneal graft rejection and infection [37], it remains unclear how these professional APCs contribute to the priming and homing of autoreactive T cells in autoimmune dry eye disease.
DCs Binding (migration) of in eye associated with inflammation, eye disease, infection and graft vs host disease
15) Confidence 0.13 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 0.67 Pain Relevance 0.12
Moreover, one will have to take into consideration that, in vivo, cellular IC-activated DCs may interact with, not only CTLs, but also other effector cells such as CD4+ lymphocytes.
DCs Binding (interact) of in lymphocytes
16) Confidence 0.12 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2883599 Disease Relevance 0 Pain Relevance 0.04
R-mediated binding to dendritic cells (DCs).
DCs Binding (binding) of in dendritic cells
17) Confidence 0.11 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2883599 Disease Relevance 0.15 Pain Relevance 0
After confirming that imDCs were able to bind and internalize CPMV, it became important to investigate whether the CPMV binding protein vimentin was displayed on their surface.
imDCs Binding (bind) of
18) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776531 Disease Relevance 0 Pain Relevance 0
These results suggest that not all of the imDCs derived from bone marrow have the ability to bind CPMV possibly because not all of them express the receptor protein vimentin that binds the CPMV particles.
imDCs Binding (bind) of in bone marrow
19) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776531 Disease Relevance 0 Pain Relevance 0
Due to the presence of two groups of DCs with high and low binding respectively (Fig. 2A), we analyzed these two populations separately.
DCs Binding (binding) of
20) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776531 Disease Relevance 0 Pain Relevance 0

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