INT58452

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 1993
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.99
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Chat) transferase activity, transferring acyl groups (Chat)
Chat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 12 100.00 Very High Very High Very High
Glutamate 5 100.00 Very High Very High Very High
antagonist 2 98.82 Very High Very High Very High
Hippocampus 7 92.16 High High
long-term potentiation 5 84.52 Quite High
tetrodotoxin 1 75.36 Quite High
Central nervous system 5 75.00 Quite High
excitatory amino acid 1 75.00 Quite High
Inflammation 9 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 127 99.76 Very High Very High Very High
Cognitive Disorder 16 99.64 Very High Very High Very High
Pain 6 99.48 Very High Very High Very High
Nociception 2 98.96 Very High Very High Very High
Injury 7 66.48 Quite High
Amyloid Plaque 5 65.52 Quite High
Targeted Disruption 3 59.36 Quite High
Apoptosis 133 58.88 Quite High
Death 56 40.48 Quite Low
Frailty 2 18.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Decrease of hippocampal choline acetyltransferase activity induced by formalin pain.
Positive_regulation (induced) of Negative_regulation (Decrease) of choline acetyltransferase associated with pain
1) Confidence 0.50 Published 1993 Journal Brain Res. Section Title Doc Link 8287273 Disease Relevance 0.28 Pain Relevance 0.57
Results indicate that the decrease in ChAT activity depends upon the presence of the nociceptive input rather than its magnitude.
Positive_regulation (depends) of Negative_regulation (decrease) of ChAT associated with nociception
2) Confidence 0.47 Published 1993 Journal Brain Res. Section Abstract Doc Link 8287273 Disease Relevance 0.26 Pain Relevance 0.25
The use of antagonists showed that ionotropic and group 1 metabotropic receptors mediated the effect of glutamate on ChAT inhibition, in a calcium dependent manner.
Positive_regulation (mediated) of Negative_regulation (inhibition) of ChAT associated with glutamate and antagonist
3) Confidence 0.16 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11359879 Disease Relevance 0 Pain Relevance 0.32
As this reduction also occurs at early stage of the disease, it clearly demonstrates a role for decreased BDNF in the cognitive impairment in AD, that even precedes the reduction of ChAT activity [89].
Positive_regulation (precedes) of Negative_regulation (reduction) of ChAT associated with cognitive disorder and disease
4) Confidence 0.07 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 1.45 Pain Relevance 0.20

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox