INT58468

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Context Info
Confidence 0.58
First Reported 1993
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 9.39
Pain Relevance 5.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (IL1A) cytosol (IL1A) extracellular space (IL1A)
extracellular region (IL1A)
Anatomy Link Frequency
macrophage 9
monocyte 3
chondrocyte 2
connective tissue 2
IL1A (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 21 99.80 Very High Very High Very High
dexamethasone 7 99.38 Very High Very High Very High
Arthritis 106 96.64 Very High Very High Very High
endometriosis 397 94.00 High High
cytokine 108 92.56 High High
aspirin 3 90.04 High High
Inflammatory response 4 89.40 High High
Osteoarthritis 123 86.40 High High
Inflammation 111 82.32 Quite High
headache 2 82.32 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 116 96.64 Very High Very High Very High
Endometriosis 504 94.00 High High
Apoptosis 24 94.00 High High
INFLAMMATION 115 89.04 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 13 87.28 High High
Osteoarthritis 125 86.40 High High
Appetite Loss 6 85.36 High High
Arthritis 20 83.76 Quite High
Cognitive Disorder 2 83.72 Quite High
Fever 2 82.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is suggested that the stimulatory action of group 1 NSAID is due to inhibition of locally produced IL1 and consequent expression of growth factor activity.
Negative_regulation (inhibition) of Gene_expression (expression) of IL1 associated with cinod
1) Confidence 0.58 Published 1999 Journal Z Rheumatol Section Abstract Doc Link 10441838 Disease Relevance 0.62 Pain Relevance 0.82
Other NSAIDs may also inhibit IL1 synthesis or release, but probably do not have a beneficial effect on chondrocyte synthetic activity as they have toxic effects on cartilage metabolism.
Spec (may) Negative_regulation (inhibit) of Gene_expression (synthesis) of IL1 in chondrocyte associated with cinod
2) Confidence 0.58 Published 1999 Journal Z Rheumatol Section Abstract Doc Link 10441838 Disease Relevance 0.39 Pain Relevance 0.69
It is suggested that the stimulatory action of group 1 NSAID is due to inhibition of locally produced IL1 and consequent expression of growth factor activity.
Negative_regulation (inhibition) of Gene_expression (produced) of IL1 associated with cinod
3) Confidence 0.43 Published 1999 Journal Z Rheumatol Section Abstract Doc Link 10441838 Disease Relevance 0.62 Pain Relevance 0.81
In particular, their use is considered for their ability to decrease IL1 and TNF production by monocytes/macrophages, as demonstrated by many authors.
Negative_regulation (decrease) of Gene_expression (production) of IL1 in macrophages
4) Confidence 0.40 Published 1993 Journal Med. Hypotheses Section Abstract Doc Link 8289691 Disease Relevance 0.98 Pain Relevance 0.24
Also, opposite to findings by Smith et al.[29], we did not find LD between SNPs in IL1R1 and the locus containing IL1A, IL1B, and IL1RN in our study material (r2 ?
Negative_regulation (locus) of Gene_expression (containing) of IL1A
5) Confidence 0.32 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2859817 Disease Relevance 0.56 Pain Relevance 0.24
DEX was also found to be a potent inhibitor of IL1-induced expression of the IL6 gene in connective tissue-type cells from the synovium of patients with RA.
Negative_regulation (inhibitor) of Gene_expression (expression) of IL1 in connective tissue associated with dexamethasone and arthritis
6) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.85 Pain Relevance 0.80
Danazol inhibits interleukin-1 (IL1) and TNF production by monocytes in a dose-dependent manner [74] and suppresses macrophage/monocyte-mediated cytotoxicity of susceptible target cells in women with mild endometriosis [75].
Negative_regulation (inhibits) of Gene_expression (production) of IL1 in macrophage associated with endometriosis
7) Confidence 0.16 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305339 Disease Relevance 1.10 Pain Relevance 0.43
In particular, their use is considered for their ability to decrease IL1 and TNF production by monocytes/macrophages, as demonstrated by many authors.
Negative_regulation (decrease) of in monocytes Gene_expression (production) of IL1 in macrophages
8) Confidence 0.14 Published 1993 Journal Med. Hypotheses Section Abstract Doc Link 8289691 Disease Relevance 0.98 Pain Relevance 0.24
Danazol inhibits interleukin-1 (IL1) and TNF production by monocytes in a dose-dependent manner [74] and suppresses macrophage/monocyte-mediated cytotoxicity of susceptible target cells in women with mild endometriosis [75].
Negative_regulation (inhibits) of Gene_expression (production) of interleukin-1 in macrophage associated with endometriosis
9) Confidence 0.12 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305339 Disease Relevance 1.10 Pain Relevance 0.43
Danazol inhibits interleukin-1 (IL1) and TNF production by monocytes in a dose-dependent manner [74] and suppresses macrophage/monocyte-mediated cytotoxicity of susceptible target cells in women with mild endometriosis [75].
Negative_regulation (inhibits) of in monocyte Gene_expression (production) of IL1 in macrophage associated with endometriosis
10) Confidence 0.06 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305339 Disease Relevance 1.10 Pain Relevance 0.43
Danazol inhibits interleukin-1 (IL1) and TNF production by monocytes in a dose-dependent manner [74] and suppresses macrophage/monocyte-mediated cytotoxicity of susceptible target cells in women with mild endometriosis [75].
Negative_regulation (inhibits) of in monocyte Gene_expression (production) of interleukin-1 in macrophage associated with endometriosis
11) Confidence 0.04 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305339 Disease Relevance 1.10 Pain Relevance 0.43

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