INT58469

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Context Info
Confidence 0.42
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 8.10
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6) aging (IL6) extracellular region (IL6)
Anatomy Link Frequency
fibroblasts 4
plasma 2
monocytes 2
carotid artery 2
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 106 100.00 Very High Very High Very High
lidocaine 8 99.74 Very High Very High Very High
Inflammation 256 96.60 Very High Very High Very High
Inflammatory mediators 25 95.04 Very High Very High Very High
antagonist 10 93.16 High High
rheumatoid arthritis 54 83.80 Quite High
headache 3 78.52 Quite High
Analgesic 2 77.84 Quite High
cINOD 11 70.64 Quite High
ischemia 7 69.88 Quite High
Disease Link Frequency Relevance Heat
Obesity 155 100.00 Very High Very High Very High
Stroke 8 99.84 Very High Very High Very High
Increased Venous Pressure Under Development 19 99.74 Very High Very High Very High
Cancer 207 99.72 Very High Very High Very High
Weight Loss 3 99.72 Very High Very High Very High
Necrosis 29 99.48 Very High Very High Very High
Arrhythmias 2 Under Development 1 99.00 Very High Very High Very High
Cv General 3 Under Development 8 98.96 Very High Very High Very High
INFLAMMATION 323 96.60 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 11 96.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The decreased induction of these cytokines and consequently of IL6 and acute phase proteins may have beneficial effects on many clinical manifestations of AIDS such as cachexia.
Negative_regulation (decreased) of Positive_regulation (induction) of IL6 associated with appetite loss, acquired immune deficiency syndrome or hiv infection and cytokine
1) Confidence 0.42 Published 1993 Journal Med. Hypotheses Section Abstract Doc Link 8289691 Disease Relevance 1.12 Pain Relevance 0.23
Concurrently, cortisol (0.01 approximately 1 microM) decreased rather than increased proinflammatory cytokine mRNA levels, including interleukin 1 beta (IL1B), interleukin 6 (IL6), and tumor necrosis factor alpha (TNF), in a dose-dependent manner in human amnion fibroblasts.
Negative_regulation (decreased) of Positive_regulation (increased) of interleukin 6 in fibroblasts associated with necrosis, cancer and cytokine
2) Confidence 0.38 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 17901074 Disease Relevance 0.27 Pain Relevance 0.17
Concurrently, cortisol (0.01 approximately 1 microM) decreased rather than increased proinflammatory cytokine mRNA levels, including interleukin 1 beta (IL1B), interleukin 6 (IL6), and tumor necrosis factor alpha (TNF), in a dose-dependent manner in human amnion fibroblasts.
Negative_regulation (decreased) of Positive_regulation (increased) of IL6 in fibroblasts associated with necrosis, cancer and cytokine
3) Confidence 0.38 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 17901074 Disease Relevance 0.27 Pain Relevance 0.17
Rac1 expression results in the induction of the IL-6 and IL-6 receptor genes and neutralizing antibodies directed against the IL-6 receptor block Rac1-induced STAT3 activation.
Negative_regulation (block) of Positive_regulation (induction) of IL-6
4) Confidence 0.37 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.06 Pain Relevance 0.04
Rac1 expression results in the induction of the IL-6 and IL-6 receptor genes and neutralizing antibodies directed against the IL-6 receptor block Rac1-induced STAT3 activation.
Negative_regulation (block) of Positive_regulation (induction) of IL-6
5) Confidence 0.37 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.06 Pain Relevance 0.04
IL-6 was upregulated at POD 5 then decreased to the intraoperative baseline value.
Negative_regulation (decreased) of Positive_regulation (upregulated) of IL-6
6) Confidence 0.33 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.16 Pain Relevance 0.04
Lidocaine (0.5 mg/mL) decreased IL-1beta (1.89 +/- 0.11 versus 4.16 +/- 1.27 pg/mL; P = 0.009), IL-6 (65.5 +/- 5.14 versus 162 +/- 11.5 pg/mL; P < 0.001), and IL-8 (3869 +/- 785 versus 14,961 +/- 406 pg/mL; P < 0.001) concentrations compared with the control.
Negative_regulation (decreased) of Positive_regulation (concentrations) of IL-6 associated with lidocaine
7) Confidence 0.33 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 15673867 Disease Relevance 0.39 Pain Relevance 0.65
LPS-induced IL-6 and PGE2 release was only slightly inhibited at high doses, whereas LPS-induced release of IL-8 and matrix metalloprotease (MMP)-9 was not affected.
Negative_regulation (inhibited) of Positive_regulation (LPS-induced) of IL-6
8) Confidence 0.30 Published 2004 Journal Scand. J. Rheumatol. Suppl. Section Abstract Doc Link 15515409 Disease Relevance 0.50 Pain Relevance 0.19
Interestingly, IL-6 may be a biomarker of carotid artery atherosclerosis,81 and high levels of IL-6 have been a predictor of stroke in those with atrial fibrillation.82
Negative_regulation (predictor) of Positive_regulation (levels) of IL-6 in carotid artery associated with stroke, arrhythmias 2 under development and increased venous pressure under development
9) Confidence 0.30 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2990387 Disease Relevance 1.30 Pain Relevance 0.04
Two-hour pre-treatment with 10 mM of both molecules significantly reverted the stimulation of IL-6, IL-8, ICAM-1 and Mcp-1, whereas the effect on I?
Negative_regulation (reverted) of Positive_regulation (stimulation) of IL-6
10) Confidence 0.28 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875647 Disease Relevance 0 Pain Relevance 0
Mu opioid receptor activation specifically mediated this morphine-induced TNF and IL-6 inhibition in monocytes.
Negative_regulation (inhibition) of Positive_regulation (morphine-induced) of IL-6 in monocytes
11) Confidence 0.26 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18349186 Disease Relevance 0 Pain Relevance 0
Elevated levels of IL-6 were detected in obese women, and were reduced after weight loss [88].
Negative_regulation (reduced) of Positive_regulation (levels) of IL-6 associated with weight loss and obesity
12) Confidence 0.17 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2857618 Disease Relevance 2.44 Pain Relevance 0.26
Beyond these potential limitations, our results suggest that prolonged AA supplementation may increase cycling anaerobic capacity while reducing circulating IL-6 levels in resistance-trained males.
Negative_regulation (reducing) of Positive_regulation (circulating) of IL-6
13) Confidence 0.11 Published 2007 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2217562 Disease Relevance 0 Pain Relevance 0.09
METHODS: We measured plasma levels of interleukin-1 beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and interleukin 6 (IL-6) in 97 patients: 67 with stable angina, 24 with unstable angina, and 15 healthy controls.
Negative_regulation (measured) of Positive_regulation (levels) of IL-6 in plasma
14) Confidence 0.11 Published 2000 Journal J. Thromb. Thrombolysis Section Body Doc Link 10728019 Disease Relevance 0.19 Pain Relevance 0
also prevents transactivation of the IL-6 promoter.
Negative_regulation (prevents) of Positive_regulation (transactivation) of IL-6
15) Confidence 0.11 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.35 Pain Relevance 0
However, Chachkhiani et al. [5] observed that during the first 24 hours after colonic resection there is a significant increase in serum IL-6 which declined during the first 48 to 72 hours.
Negative_regulation (declined) of Positive_regulation (increase) of IL-6
16) Confidence 0.09 Published 2010 Journal Crit Care Section Body Doc Link PMC2887140 Disease Relevance 0.98 Pain Relevance 0.23

General Comments

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