INT5847

Context Info Confidence 0.69 First Reported 1992 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 31 Total Number 33 Disease Relevance 11.11 Pain Relevance 6.41

nucleoplasm (FOS) aging (FOS) nucleolus (FOS) nucleus (FOS)

Anatomy Link Frequency neuronal 2 embryos 1 FOS (Homo sapiens)

Pain Link Frequency Relevance Heat Neuropeptide 24 100.00 Dynorphin 14 100.00 Morphine 11 98.70 chemokine 12 98.38 Enkephalin 20 98.00 tetrodotoxin 9 97.92 Hippocampus 25 97.00 Arthritis 108 96.72 Inflammation 189 96.48 ischemia 10 96.28

Disease Link Frequency Relevance Heat Cancer 171 100.00 Necrosis 17 100.00 Aids-related Complex 14 100.00 Osteogenic Sarcomas 10 100.00 Sarcoma 2 100.00 Thymoma 2 99.88 Carcinoma 5 98.66 Convulsion 6 98.44 Disease 103 97.92 Metastasis 90 97.44

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Characterization of the time course of mRNA expression for Camk1g, Gpd1, c-fos and Egr1 demonstrates that altered expression of these transcripts also occurs at times earlier than 6 h following acute, oral pyrethroid exposure (Figure 4, Additional file 5).

Transcription (expression) of c-fos

1) Confidence 0.69 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.14 Pain Relevance 0.13

Dose-dependent changes in the transcription of several genes (Camk1g, Ddc, Gpd3, c-fos and Egr1) were discovered and successfully confirmed.

Transcription (transcription) of c-fos

2) Confidence 0.69 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.19 Pain Relevance 0.03

DREAM (calsenilin/KChIP3) is an EF-hand calcium-binding protein that binds to specific DNA sequences and regulates Ca2+-induced transcription of prodynorphin and c-fos genes.

Transcription (transcription) of c-fos

3) Confidence 0.69 Published 2008 Journal Biochemistry Section Abstract Doc Link 18201103 Disease Relevance 0 Pain Relevance 0

DADLE acted against this effect of METH at least in part by attenuating the mRNA expressions of a tumor necrosis factor p53 and an immediate early gene c-fos.

Transcription (expressions) of c-fos associated with necrosis and cancer

4) Confidence 0.69 Published 2000 Journal J. Biomed. Sci. Section Abstract Doc Link 10810237 Disease Relevance 0.47 Pain Relevance 0.55

In addition to the prodynorphin promoter, DREAM represses transcription from the early response gene c-fos.

Transcription (transcription) of c-fos

5) Confidence 0.69 Published 1999 Journal Nature Section Abstract Doc Link 10078534 Disease Relevance 0.08 Pain Relevance 0.12

Morphine at concentrations of 10(-12) M to 10(-10) M also modulated mRNA expression of early growth related genes (c-fos, c-jun and c-myc).

Transcription (expression) of c-fos associated with morphine

6) Confidence 0.69 Published 1998 Journal Kidney Int. Section Abstract Doc Link 9461094 Disease Relevance 0.48 Pain Relevance 0.76

In this study, gene transcription for three immediate early genes, c-fos, c-jun and NGFI-A, and three neuropeptide genes, enkephalin, dynorphin and neuropeptide Y, was investigated using nuclear run-on assays following a single injection of the convulsant pentylenetetrazole (PTZ).

Spec (investigated) Transcription (transcription) of c-fos associated with dynorphin, neuropeptide and enkephalin

7) Confidence 0.69 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8170346 Disease Relevance 0.17 Pain Relevance 0.44

At 15 min following PTZ injection, only transcription for c-fos was increased.

Transcription (transcription) of c-fos

8) Confidence 0.69 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8170346 Disease Relevance 0.16 Pain Relevance 0.51

Thus, regulation of immediate early and neuropeptide gene mRNA levels and immunoreactivity occurs, at least in part, at the level of transcription for the genes encoding neuropeptide Y, dynorphin, c-fos, c-jun, and NGFI-A.

Transcription (transcription) of c-fos associated with dynorphin and neuropeptide

9) Confidence 0.69 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8170346 Disease Relevance 0.14 Pain Relevance 0.49

The immediate early gene (IEG) transcription factor c-fos coordinates changes in the pattern of long term gene expression and, therefore, it may be involved in mediating epigenetic control during neurodevelopment.

Transcription (transcription) of c-fos

10) Confidence 0.67 Published 1995 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 8612322 Disease Relevance 0 Pain Relevance 0.18

Like other transcription factors, such as AP-1 proteins, c-fos, and c-Jun, phosphorylated CREB may participate in the downstream signal transduction cascade in the longer lasting changes in synaptic plasticity.

Transcription (transcription) of c-fos

11) Confidence 0.67 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0.43 Pain Relevance 0.71

Fifteen days after the lesion of the AC, the number of c-Fos Ir nuclei was 36% lower that in controls and 90?

Transcription (number) of c-Fos

12) Confidence 0.67 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2981384 Disease Relevance 0 Pain Relevance 0

The immediate early transcription factors c-fos and Egr1 were upregulated by deltamethrin and permethrin.

Transcription (transcription) of c-fos

13) Confidence 0.67 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.09 Pain Relevance 0.12

c-Fos densitometry and morphometry

Transcription (densitometry) of c-Fos

14) Confidence 0.67 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2981384 Disease Relevance 0 Pain Relevance 0

days after cortical ablation, the number of c-Fos immunoreactive neuronal nuclei in the IC tends to increase relative to shorter post-lesion times (1 and 15?

Transcription (nuclei) of c-Fos in neuronal

15) Confidence 0.67 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2981384 Disease Relevance 0 Pain Relevance 0.08

days after the lesion, the distribution of c-Fos Ir neuronal nuclei in the IC was similar to the 90?

Transcription (distribution) of c-Fos in neuronal

16) Confidence 0.67 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2981384 Disease Relevance 0 Pain Relevance 0

The 27 upregulated genes encoded seven transcription factors (JUN, EGR1, JUNB, FOS, FOSB, MYCN, and SNAIL1), four of which are components of the AP-1 transcription factor family (JUN, JUNB, FOS, and FOSB).

Transcription (transcription) of AP-1

17) Confidence 0.53 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.18 Pain Relevance 0.09

The 27 upregulated genes encoded seven transcription factors (JUN, EGR1, JUNB, FOS, FOSB, MYCN, and SNAIL1), four of which are components of the AP-1 transcription factor family (JUN, JUNB, FOS, and FOSB).

Transcription (transcription) of FOS

18) Confidence 0.53 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.19 Pain Relevance 0.09

The 27 upregulated genes encoded seven transcription factors (JUN, EGR1, JUNB, FOS, FOSB, MYCN, and SNAIL1), four of which are components of the AP-1 transcription factor family (JUN, JUNB, FOS, and FOSB).

Transcription (transcription) of FOS

19) Confidence 0.53 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.12 Pain Relevance 0.09

In contrast, for permethrin no change in the expression of c-fos and Egr1 mRNA was observed across dose groups in the qRT-PCR cohort.

Transcription (expression) of c-fos

20) Confidence 0.52 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.15 Pain Relevance 0.09

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