INT58470

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Context Info
Confidence 0.43
First Reported 1994
Last Reported 2011
Negated 3
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 7.20
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS) small molecule metabolic process (INS) extracellular region (INS)
carbohydrate metabolic process (INS) cell-cell signaling (INS)
Anatomy Link Frequency
plasma 6
HBP 2
heart 2
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 21 93.56 High High
Angina 8 93.36 High High
chemokine 3 90.72 High High
withdrawal 8 87.44 High High
adenocard 3 73.52 Quite High
Pain 29 72.72 Quite High
Inflammation 21 5.00 Very Low Very Low Very Low
Bioavailability 16 5.00 Very Low Very Low Very Low
headache 10 5.00 Very Low Very Low Very Low
agonist 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoglycemia 65 100.00 Very High Very High Very High
Hyperglycemia 52 100.00 Very High Very High Very High
Hypersensitivity 15 100.00 Very High Very High Very High
Obesity 29 99.98 Very High Very High Very High
Insulin Resistance 34 99.74 Very High Very High Very High
Coronary Artery Disease 7 99.08 Very High Very High Very High
Diabetes Mellitus 856 98.80 Very High Very High Very High
Myocardial Infarction 7 94.64 High High
Stress 25 94.44 High High
Toxicity 13 94.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, individuals randomized to inhaled insulin plus oral agents had a greater likelihood of reaching glycemic targets compared to those on oral agents alone (32% vs 1%).38
Negative_regulation (inhaled) of insulin Binding (agents) of
1) Confidence 0.43 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835554 Disease Relevance 0.27 Pain Relevance 0
First, the antibodies may bind to the insulin blocking its action with resulting hyperglycemia.63,64 Secondly, the insulin may then be released from the antibody complex, with inappropriate insulin action (discordant with carbohydrate intake) and delayed hypoglycemia.65,66 In rare cases, true insulin allergies may develop.62
Negative_regulation (blocking) of insulin Binding (action) of associated with hypoglycemia, hyperglycemia and hypersensitivity
2) Confidence 0.43 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835554 Disease Relevance 0.59 Pain Relevance 0.04
First, the antibodies may bind to the insulin blocking its action with resulting hyperglycemia.63,64 Secondly, the insulin may then be released from the antibody complex, with inappropriate insulin action (discordant with carbohydrate intake) and delayed hypoglycemia.65,66 In rare cases, true insulin allergies may develop.62
Spec (may) Negative_regulation (develop.62) of insulin Binding (bind) of associated with hypoglycemia, hyperglycemia and hypersensitivity
3) Confidence 0.43 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835554 Disease Relevance 0.70 Pain Relevance 0.04
capability of manually adding extra insulin to the basal rate for the intensive
Negative_regulation (capability) of insulin Binding (adding) of
4) Confidence 0.43 Published 2008 Journal International Journal of Telemedicine and Applications Section Body Doc Link PMC2271045 Disease Relevance 0.18 Pain Relevance 0
delivers a basal rate of exogenous insulin automatically and also has
Negative_regulation (delivers) of insulin Binding (rate) of
5) Confidence 0.43 Published 2008 Journal International Journal of Telemedicine and Applications Section Body Doc Link PMC2271045 Disease Relevance 0.19 Pain Relevance 0.05
examples of the partially closed-loop controls are the automated insulin dosage
Negative_regulation (closed) of insulin Binding (dosage) of
6) Confidence 0.43 Published 2008 Journal International Journal of Telemedicine and Applications Section Body Doc Link PMC2271045 Disease Relevance 0.10 Pain Relevance 0.07
Reduced insulin secretion and reduced binding capacity of insulin to its receptors may explain the elevated levels of plasma glucose in Type 3 diabetics exposed to electromagnetic fields.
Negative_regulation (reduced) of insulin Binding (capacity) of in plasma associated with diabetes mellitus
7) Confidence 0.39 Published 2008 Journal Electromagnetic Biology and Medicine Section Body Doc Link PMC2557071 Disease Relevance 0.92 Pain Relevance 0
In a similar population of patients with T2DM, AERx® premeal inhaled insulin was compared to premeal subcutaneous regular insulin, both in combination with bedtime NPH insulin.40 After 12 weeks of therapy, there was no difference in HbA1c between the two groups, and both groups experienced a similar decline in HbA1c from baseline (?
Neg (no) Negative_regulation (was) of insulin Binding (combination) of associated with diabetes mellitus
8) Confidence 0.37 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835554 Disease Relevance 0.38 Pain Relevance 0
Transient decrease of binding of insulin to platelets in acute ischemic heart disease.
Negative_regulation (decrease) of insulin Binding (binding) of in heart associated with coronary artery disease
9) Confidence 0.26 Published 1994 Journal Am. J. Med. Sci. Section Title Doc Link 8291502 Disease Relevance 0.38 Pain Relevance 0.22
The decreased binding of insulin and the relatively low mean plasma insulin level during the acute ischemic condition improved into the normal range during 8 to 12 weeks of recuperation.
Negative_regulation (decreased) of insulin Binding (binding) of in plasma
10) Confidence 0.26 Published 1994 Journal Am. J. Med. Sci. Section Abstract Doc Link 8291502 Disease Relevance 0.34 Pain Relevance 0.21
In fact, the HBP line does not express IR, therefore in this case the protective effect of insulin can not be due to its reduced binding to IR.
Negative_regulation (reduced) of insulin Binding (binding) of in HBP
11) Confidence 0.25 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2871552 Disease Relevance 0.40 Pain Relevance 0
The age-associated reduction in glucose uptake is not due to impaired insulin binding, but instead to a defect in the postreceptor intracellular insulin signaling pathway [53, 55–57].
Negative_regulation (impaired) of insulin Binding (binding) of
12) Confidence 0.23 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3010636 Disease Relevance 0.77 Pain Relevance 0.11
Interestingly, insulin did not have such
Neg (not) Negative_regulation (not) of insulin Binding (have) of
13) Confidence 0.21 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2288642 Disease Relevance 0.31 Pain Relevance 0.05
The decreased binding of insulin and the relatively low mean plasma insulin level during the acute ischemic condition improved into the normal range during 8 to 12 weeks of recuperation.
Negative_regulation (decreased) of insulin Binding (binding) of in plasma
14) Confidence 0.19 Published 1994 Journal Am. J. Med. Sci. Section Abstract Doc Link 8291502 Disease Relevance 0.34 Pain Relevance 0.21
-cell dysfunction due to various environmental and genetic factors results in onset of T2DM.6,7 Despite obesity being the single most important contributor to IR, most obese insulin-resistant individuals do not develop T2DM8,9 because their ?
Neg (not) Negative_regulation (develop) of insulin-resistant Binding (individuals) of associated with diabetes mellitus, obesity and insulin resistance
15) Confidence 0.18 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC2943223 Disease Relevance 1.33 Pain Relevance 0

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