INT58475

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Context Info
Confidence 0.75
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 5.94
Pain Relevance 3.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Rac1) enzyme binding (Rac1) GTPase activity (Rac1)
cytoplasm (Rac1) cell proliferation (Rac1) cell motility (Rac1)
Anatomy Link Frequency
nerve 2
bladder 2
neuronal 1
UES 1
neurons 1
Rac1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Botox 20 100.00 Very High Very High Very High
Inflammation 6 100.00 Very High Very High Very High
Neurolysis 4 100.00 Very High Very High Very High
Calcitonin gene-related peptide 2 100.00 Very High Very High Very High
Pain 8 99.80 Very High Very High Very High
Snapping jaw 7 99.68 Very High Very High Very High
alcohol 1 99.44 Very High Very High Very High
headache 13 99.28 Very High Very High Very High
c fibre 2 94.56 High High
Migraine 5 88.56 High High
Disease Link Frequency Relevance Heat
Dislocations 10 100.00 Very High Very High Very High
INFLAMMATION 6 100.00 Very High Very High Very High
Neuroma 1 100.00 Very High Very High Very High
Temporomandibular Joint Syndrome 7 99.68 Very High Very High Very High
Overactive Bladder 8 99.60 Very High Very High Very High
Contracture 3 99.56 Very High Very High Very High
Headache 13 99.28 Very High Very High Very High
Spasticity 4 97.80 Very High Very High Very High
Paresis 1 97.64 Very High Very High Very High
Muscle Hypertonia 2 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Enhanced ATP release from rat bladder urothelium during chronic bladder inflammation: effect of botulinum toxin A.
Localization (release) of botulinum toxin in bladder associated with inflammation
1) Confidence 0.75 Published 2005 Journal Neurochem. Int. Section Title Doc Link 15970360 Disease Relevance 0.48 Pain Relevance 0.14
Cystometry revealed that cyclophosphamide and botulinum toxin A treatments altered non-voiding (i.e. cyclophosphamide increased, botulinum toxin A decreased) but not voiding contraction frequency suggesting that alterations in urothelial ATP release selectively diminished underlying bladder C-fiber nerve activity.
Localization (decreased) of botulinum toxin in bladder associated with c fibre and overactive bladder
2) Confidence 0.75 Published 2005 Journal Neurochem. Int. Section Abstract Doc Link 15970360 Disease Relevance 0.56 Pain Relevance 0.16
[Botulinum toxin treatment of neurogenic dislocation of the temporomandibular joint].
Localization (dislocation) of Botulinum toxin in temporomandibular joint associated with snapping jaw and dislocations
3) Confidence 0.64 Published 1998 Journal Mund Kiefer Gesichtschir Section Title Doc Link 9658838 Disease Relevance 1.34 Pain Relevance 0.50
Since dysphagia and deglutition problems combined with aspiration are often caused by spasticity, hypertonus, or delayed relaxation of the upper esophageal sphincter (UES), conventional treatment including lateral cricopharyngotomy was replaced by localized injections of botulinum toxin into the cricopharyngeal muscle (CM) in a series of 7 patients.
Localization (localized) of botulinum toxin in UES associated with muscle hypertonia, spasticity and dysphagia
4) Confidence 0.60 Published 1994 Journal Ann. Otol. Rhinol. Laryngol. Section Abstract Doc Link 8291857 Disease Relevance 0.62 Pain Relevance 0.06
[Clinical use of botulinum toxin].
Localization (use) of botulinum toxin associated with pain
5) Confidence 0.58 Published 2008 Journal Nervenarzt Section Title Doc Link 18927958 Disease Relevance 0.18 Pain Relevance 0.19
Treatment consist of physical therapy, administration of botulinum toxin, electrical stimulation, neurolysis, nervatization, removal of neuromas and nerve grafting, treatment of fractures and subluxation, release of muscle contracture and tendon transplantation.
Localization (release) of botulinum toxin in nerve associated with neurolysis, contracture and neuroma
6) Confidence 0.56 Published 1998 Journal Rev Neurol Section Abstract Doc Link 9736956 Disease Relevance 0.97 Pain Relevance 0.17
Topics that will be discussed include techniques for localization, strengths and limitations of various agents (botulinum toxin, phenol, and alcohol), the value of combination therapies, and the role of nerve blocks (diagnostic and therapeutic).
Localization (localization) of botulinum toxin in nerve associated with alcohol
7) Confidence 0.56 Published 2009 Journal PM R Section Abstract Doc Link 19769919 Disease Relevance 0.28 Pain Relevance 0.29
This finding may help to explain the enthusiasm that followed the first open-label use of botulinum toxin in patients with headache.
Localization (use) of botulinum toxin associated with headache
8) Confidence 0.54 Published 2008 Journal J Neural Transm Section Abstract Doc Link 17994180 Disease Relevance 1.21 Pain Relevance 1.34
Taken together, the results demonstrate that these 2 formulations of botulinum toxin type A, onabotulinumtoxinA and abobotulinumtoxinA, are safe and well tolerated based on both shorter- and longer-term studies.


Localization (tolerated) of botulinum toxin associated with botox
9) Confidence 0.13 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2861845 Disease Relevance 0.07 Pain Relevance 0.05
Botulinum toxin, a neurotoxin with high affinity for cholinergic synapses, blocks the release of acetylcholine by nerve endings without interfering with neuronal conduction of electrical signals or synthesis and storage of acetylcholine.
Localization (release) of Botulinum toxin in neuronal
10) Confidence 0.10 Published 2009 Journal Rev Bras Anestesiol Section Body Doc Link 19488551 Disease Relevance 0.09 Pain Relevance 0
Perioperative use of botulinum toxin and halo vest immobilization can increase the rate of clinical success but requires vigilance to minimize complications.
Localization (use) of botulinum toxin
11) Confidence 0.06 Published 2005 Journal J Spinal Disord Tech Section Body Doc Link 15699795 Disease Relevance 0.06 Pain Relevance 0
OBJECTIVES: To determine the effect of botulinum toxin type A on calcitonin gene-related peptide secretion from cultured trigeminal ganglia neurons.
Localization (secretion) of botulinum toxin in neurons associated with calcitonin gene-related peptide and botox
12) Confidence 0.02 Published 2004 Journal Headache Section Abstract Doc Link 14979881 Disease Relevance 0.07 Pain Relevance 0.29

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