INT58484

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Context Info
Confidence 0.45
First Reported 1993
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 12
Total Number 15
Disease Relevance 8.67
Pain Relevance 6.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il4) extracellular region (Il4)
Anatomy Link Frequency
plasma 2
lymphocyte 1
dorsal root ganglion 1
microglia 1
Il4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 110 99.74 Very High Very High Very High
Neuritis 12 99.48 Very High Very High Very High
dorsal root ganglion 23 99.16 Very High Very High Very High
Inflammation 98 98.92 Very High Very High Very High
fibrosis 7 98.36 Very High Very High Very High
Migraine 9 98.28 Very High Very High Very High
tetrodotoxin 7 97.04 Very High Very High Very High
Neuropathic pain 29 96.16 Very High Very High Very High
Inflammatory mediators 3 95.76 Very High Very High Very High
Peripheral nervous system 2 95.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cold Sores 22 100.00 Very High Very High Very High
Immune System Diseases 1 99.56 Very High Very High Very High
INFLAMMATION 116 99.54 Very High Very High Very High
Experimental Autoimmune Neuritis 12 99.48 Very High Very High Very High
Injury 46 99.32 Very High Very High Very High
Ganglion Cysts 24 98.68 Very High Very High Very High
Fibrosis 7 98.36 Very High Very High Very High
Immunization 2 98.32 Very High Very High Very High
Headache 7 98.28 Very High Very High Very High
Demyelinating Disease 11 98.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we examined the effect of recombinant rat interleukin-4 (rrIL-4) on chronic EAN in Lewis rats induced by immunization with P0 peptide 180-199 and complete Freund's adjuvant (CFA).
Spec (examined) Regulation (effect) of interleukin-4 associated with immunization and neuritis
1) Confidence 0.45 Published 1999 Journal J. Autoimmun. Section Abstract Doc Link 10047428 Disease Relevance 0.99 Pain Relevance 0.68
After optimization of the transduction protocol, effects of the IL-4 gene transfer on pancreatic inflammation and fibrosis were studied in DBTC-treated rats.
Regulation (effects) of IL-4
2) Confidence 0.44 Published 2005 Journal Scand. J. Gastroenterol. Section Body Doc Link 16165721 Disease Relevance 0 Pain Relevance 0
Serum IL-4 levels in control and thermally injured animals remained undetectable (< 15.6 pg/mL) throughout the experiment.
Regulation (undetectable) of IL-4
3) Confidence 0.44 Published 2001 Journal Shock Section Abstract Doc Link 11699077 Disease Relevance 0.76 Pain Relevance 0.11
In this study, we examined the effect of recombinant rat interleukin-4 (rrIL-4) on chronic EAN in Lewis rats induced by immunization with P0 peptide 180-199 and complete Freund's adjuvant (CFA).
Spec (examined) Regulation (effect) of rrIL-4 associated with immunization and neuritis
4) Confidence 0.39 Published 1999 Journal J. Autoimmun. Section Abstract Doc Link 10047428 Disease Relevance 1.00 Pain Relevance 0.69
This study examines the alterations in serum levels of TGF-beta and IL-4 after a thermal injury.
Spec (examines) Regulation (alterations) of IL-4 associated with injury
5) Confidence 0.26 Published 2001 Journal Shock Section Abstract Doc Link 11699077 Disease Relevance 0.71 Pain Relevance 0.13
These actions are associated with a concurrent effect on the antiinflammatory cytokines, namely the regulation of IL-4 function, possibly via a direct effect on the lymphocyte T population.
Regulation (regulation) of IL-4 in lymphocyte associated with inflammation and cytokine
6) Confidence 0.26 Published 2008 Journal J Transl Med Section Body Doc Link PMC2435101 Disease Relevance 0.79 Pain Relevance 0.21
To examine the role of inflammatory mediators in neuropathic pain, we used a replication-defective genomic herpes simplex virus (HSV)-based vector containing the coding sequence for the anti-inflammatory peptide interleukin (IL)-4 under the transcriptional control of the HSV ICP4 immediate early promoter, vector S4IL4, to express IL-4 in dorsal root ganglion (DRG) neurons in vivo.


Regulation (control) of S4IL4 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, inflammatory mediators, cold sores, inflammation, herpes simplex virus and neuropathic pain
7) Confidence 0.19 Published 2006 Journal Mol Pain Section Abstract Doc Link PMC1395302 Disease Relevance 1.43 Pain Relevance 0.92
The change of IL-4 was little in both groups and the level was less than 40 pg/mL throughout the experimental period (Figure 6, middle).
Regulation (change) of IL-4
8) Confidence 0.11 Published 2008 Journal Crit Care Section Body Doc Link PMC2575560 Disease Relevance 0.17 Pain Relevance 0.03
The down-regulation of IL-4, a canonical Th2 cytokine, suggests that Th1 pathways might predominate in this setting.
Regulation (regulation) of IL-4 associated with cytokine
9) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 1.07 Pain Relevance 0.30
There were no differences in corticosterone, IFN-gamma and IL-4 levels.
Neg (no) Regulation (differences) of IL-4
10) Confidence 0.06 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link 20615224 Disease Relevance 0.78 Pain Relevance 0.20
Time-data series analysis showed a fall after a challenge test for IL-4 and IL-6 plasma levels and an opposite trend for gamma-IFN and GM-CSF levels.
Regulation (trend) of IL-4 in plasma
11) Confidence 0.06 Published 1993 Journal Headache Section Abstract Doc Link 8294190 Disease Relevance 0.36 Pain Relevance 0.56
CXCL-10 in vitro and IL-4 in vivo mRNA levels were far less affected by Pin1 blockade, suggesting Pin1 regulates only the most labile AU-rich mRNAs.
Regulation (affected) of IL-4
12) Confidence 0.03 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.09 Pain Relevance 0.09
Phenytoin attenuated by approximately 50% the release of IL-1 alpha, IL-1 beta, and TNF-alpha from LPS-stimulated microglia, but had minimal effects on the release of IL-2, IL-4, IL-6, IL-10, MCP-1, and TGF-alpha.
Regulation (effects) of IL-4 in microglia
13) Confidence 0.02 Published 2009 Journal Glia Section Abstract Doc Link 19115387 Disease Relevance 0 Pain Relevance 1.67
To this end, plasma levels of IFN-gamma, IL-4, IL-5, and IL-10 were measured by enzyme-linked immunosorbent assay (ELISA) techniques.
Regulation (measured) of IL-4 in plasma
14) Confidence 0.01 Published 1998 Journal Headache Section Abstract Doc Link 9664752 Disease Relevance 0.34 Pain Relevance 0.52
The concentrations of TNF-alpha, GM-CSF, interleukin (IL)-1beta, IL-6, IL-8, interferon (IFN)-gamma, IL-2, IL-4, IL-5, IL-10 and nitrate/nitrite were determined.
Regulation (concentrations) of IL-4
15) Confidence 0.01 Published 2007 Journal Inflamm. Res. Section Body Doc Link 17334668 Disease Relevance 0.17 Pain Relevance 0

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