INT58489

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Context Info
Confidence 0.41
First Reported 1994
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 51
Total Number 53
Disease Relevance 4.70
Pain Relevance 5.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rorb) cellular_component (Rorb)
Anatomy Link Frequency
neurons 9
striatum 2
lenses 2
auditory cortex 2
cortex 2
Rorb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 75 100.00 Very High Very High Very High
cytokine 26 100.00 Very High Very High Very High
Opioid 1 100.00 Very High Very High Very High
nMDA receptor 65 99.34 Very High Very High Very High
medulla 7 99.16 Very High Very High Very High
fluoxetine 8 98.68 Very High Very High Very High
Hippocampus 53 98.62 Very High Very High Very High
mu opioid receptor 160 97.88 Very High Very High Very High
Somatosensory cortex 31 97.84 Very High Very High Very High
rheumatoid arthritis 18 97.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 97 100.00 Very High Very High Very High
Esophageal Disease 4 99.16 Very High Very High Very High
Cognitive Disorder 7 98.84 Very High Very High Very High
Convulsion 2 98.80 Very High Very High Very High
Rheumatoid Arthritis 75 97.68 Very High Very High Very High
Hyperalgesia 4 96.96 Very High Very High Very High
Schizophrenia 3 94.56 High High
Disease 20 93.88 High High
Arthritis 10 90.28 High High
Neurodegenerative Disease 11 87.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the expression of many genes associated with cytokine and transcription factor was enhanced in the esophagitis rats.
Gene_expression (expression) of transcription factor associated with esophageal disease and cytokine
1) Confidence 0.41 Published 2006 Journal Int. J. Mol. Med. Section Abstract Doc Link 17016611 Disease Relevance 0.48 Pain Relevance 0.15
Kainic acid up-regulated the expression of the inflammatory cytokines IL-1beta and TNF-alpha, the neurotrophic factor IGF-1, and the transcription factor NF-kappaB.
Gene_expression (expression) of transcription factor associated with inflammation and cytokine
2) Confidence 0.25 Published 2008 Journal Nutr Neurosci Section Abstract Doc Link 18681986 Disease Relevance 0.70 Pain Relevance 0.53
These results suggest that chronic treatments with neuroleptics having different effects on cognitive and motor behavior induce different long-term changes in transcription factor expression in the striatum.
Gene_expression (expression) of transcription factor in striatum associated with cognitive disorder
3) Confidence 0.24 Published 1996 Journal J. Comp. Neurol. Section Abstract Doc Link 8891947 Disease Relevance 0.10 Pain Relevance 0.09
Atypical and typical neuroleptic treatments induce distinct programs of transcription factor expression in the striatum.
Gene_expression (expression) of transcription factor in striatum
4) Confidence 0.24 Published 1996 Journal J. Comp. Neurol. Section Title Doc Link 8891947 Disease Relevance 0.09 Pain Relevance 0
Nevertheless, we found that neuroleptics of both classes regulated transcription factor expression in overlapping populations of striatal neurons expressing enkephalin or DARPP-32.
Gene_expression (expression) of transcription factor in neurons associated with enkephalin
5) Confidence 0.24 Published 1996 Journal J. Comp. Neurol. Section Abstract Doc Link 8891947 Disease Relevance 0.09 Pain Relevance 0.10
Transcription factor modulation and expression in the rat auditory brainstem following electrical intracochlear stimulation.
Gene_expression (expression) of Transcription factor in brainstem associated with medulla
6) Confidence 0.16 Published 2002 Journal Exp. Neurol. Section Title Doc Link 12009775 Disease Relevance 0 Pain Relevance 0.16
The synthesis is regulated mainly by the transcription factors NF-IL-6, CAAT-enhancer-binding protein (C/EBP)-?
Gene_expression (factors) of transcription
7) Confidence 0.11 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 1.50 Pain Relevance 0.66
Unlike in adult hippocampus, seizure activity caused by kainate treatment does not increase the transcription factor and opioid peptide gene expression in the hippocampi of P7 rats.
Gene_expression (expression) of transcription factor in hippocampus associated with convulsion, hippocampus and opioid
8) Confidence 0.11 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8294905 Disease Relevance 0.16 Pain Relevance 0.54
Transcription factor expression in regenerated lenses
Gene_expression (expression) of Transcription factor in lenses
9) Confidence 0.05 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2834568 Disease Relevance 0 Pain Relevance 0
The consistency with the RORbeta gene expression supports this area delineation.
Gene_expression (expression) of RORbeta
10) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0.04
The PC1–PC2 plot of different cortical areas shown in Fig. 7B indicates the features of these areas characterized by RORbeta, ER81 and Nurr1 gene expressions.
Gene_expression (expressions) of RORbeta
11) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0
For example, the expression level of RORbeta mRNA was higher in layers 2/3 of the Par1 subfield of the somatosensory cortex and the auditory cortex, which is consistent with the findings described in a previous report [8].
Gene_expression (expression) of RORbeta mRNA in auditory cortex associated with somatosensory cortex
12) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0.05
However, the layer 5 neurons expressing RORbeta mRNA mostly coexpressed ER81 mRNA.
Gene_expression (expressing) of RORbeta mRNA in neurons
13) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0
The distribution pattern shown in Fig. 6A suggests that the RORbeta mRNA expression level is high in the sensory areas, whereas the ER81 and Nurr1 mRNA expression levels are generally high in the areas with low RORbeta mRNA expression level.
Gene_expression (expression) of RORbeta mRNA
14) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0
Layer 4 neurons generally expressed only RORbeta mRNA, while many layer 5 neurons expressed only ER81 mRNA.
Gene_expression (expressed) of RORbeta mRNA in neurons
15) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0
In the auditory cortex, we distinguished Te1 and Te3V, on the basis of Nissl-GLI and RORbeta expression.
Gene_expression (expression) of RORbeta in auditory cortex
16) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0.03
For example, although RORbeta mRNA is clearly expressed by layer 5 neurons throughout areas (Fig. 2), it does not show up in the layer 5 map (Fig. 6A).
Gene_expression (expressed) of RORbeta mRNA in neurons
17) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0
The expressions of RORbeta, ER81 and/or Nurr1 genes may be affected, directly or indirectly, by the thalamocortical inputs and contribute to the low PC1 scores in the primary sensory areas.
Gene_expression (expressions) of RORbeta
18) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0.05
On the other hand, RORbeta and Nurr1 mRNAs were not coexpressed in the same neurons even in the areas with extensive intermingling (Fig. 3D–3F).
Neg (not) Gene_expression (coexpressed) of RORbeta in neurons
19) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0
Second, at single cell level, RORbeta and ER81 mRNAs were coexpressed in a subpopulation of layer 5 neurons, whereas Nurr1 and ER81 mRNAs were not colocalized.
Gene_expression (coexpressed) of RORbeta in neurons
20) Confidence 0.04 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0

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