INT58495

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Context Info
Confidence 0.49
First Reported 1994
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 22
Total Number 23
Disease Relevance 2.44
Pain Relevance 17.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Oprm1)
Anatomy Link Frequency
nucleus accumbens 4
plasma 2
spinal cord 2
caudate-putamen 2
striatum 2
Oprm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 66 100.00 Very High Very High Very High
agonist 41 100.00 Very High Very High Very High
mu opioid receptor 30 100.00 Very High Very High Very High
Opioid 24 100.00 Very High Very High Very High
Enkephalin 18 100.00 Very High Very High Very High
Periaqueductal grey 6 100.00 Very High Very High Very High
Glutamate 2 100.00 Very High Very High Very High
gABA 1 100.00 Very High Very High Very High
Nucleus accumbens 8 99.96 Very High Very High Very High
addiction 14 99.66 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 10 100.00 Very High Very High Very High
Convulsion 6 99.18 Very High Very High Very High
Diabetes Mellitus 4 96.64 Very High Very High Very High
Hypotension 1 95.92 Very High Very High Very High
Hypersensitivity 1 95.64 Very High Very High Very High
Nociception 3 95.60 Very High Very High Very High
Pain 4 94.84 High High
Myocardial Infarction 1 92.52 High High
INFLAMMATION 1 92.40 High High
Syndrome 1 90.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Opiate analgesia, tolerance, and addiction are mediated by drug-induced activation of the mu opioid receptor.
Positive_regulation (drug-induced) of Positive_regulation (activation) of mu opioid receptor associated with addiction, mu opioid receptor, tolerance, opiate and analgesia
1) Confidence 0.49 Published 1999 Journal Neuron Section Abstract Doc Link 10482240 Disease Relevance 0 Pain Relevance 1.09
BACKGROUND: It has been reported that mu-opioid receptor activation leads to a sustained increase in glutamate synaptic effectiveness at the N-methyl-D-aspartate (NMDA) receptor level, a system associated with central hypersensitivity to pain.
Positive_regulation (increase) of Positive_regulation (activation) of mu-opioid receptor associated with pain, glutamate, hypersensitivity and opioid receptor
2) Confidence 0.47 Published 2000 Journal Anesthesiology Section Abstract Doc Link 10691234 Disease Relevance 0.43 Pain Relevance 0.77
CONCLUSIONS: The low intrathecal potency of oxycodone in rats seems be related to its low efficacy and potency to stimulate mu-opioid receptor activation in the spinal cord.


Positive_regulation (stimulate) of Positive_regulation (activation) of mu-opioid receptor in spinal cord
3) Confidence 0.47 Published 2006 Journal Anesthesiology Section Body Doc Link 17006080 Disease Relevance 0 Pain Relevance 0
In the presence of agonist, NO increased constitutive activation of the mu-opioid receptor and reduced the ability of a selective mu-opioid agonist to activate the mu-opioid G-protein-coupled receptor; these molecular effects occurred in a time course consistent with the development of antinociceptive tolerance.
Neg (NO) Positive_regulation (increased) of Neg (NO) Positive_regulation (activation) of mu-opioid receptor associated with mu agonist, tolerance, agonist, opioid receptor, antinociceptive and opioid
4) Confidence 0.47 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15670586 Disease Relevance 0 Pain Relevance 1.67
We have previously demonstrated that continuous cocaine treatment for three days induces a marked but transient increase in mu opioid receptor (MOR) mRNA in nucleus accumbens (n. acc.); SCH 23390 and eticlopride, selective antagonists of D1- and D2-like dopamine (DA) receptors, respectively, blocked this cocaine-induced upregulation of MOR mRNA in n. acc. suggesting involvement of both subfamilies of DA receptors in the effect of cocaine (1,2).
Positive_regulation (induces) of Positive_regulation (increase) of mu opioid receptor in nucleus accumbens associated with nucleus accumbens, dopamine, antagonist, mu opioid receptor and cocaine
5) Confidence 0.45 Published 1996 Journal Neurochem. Res. Section Abstract Doc Link 8947931 Disease Relevance 0 Pain Relevance 0.86
High levels of mu opioid receptor activation during the postpartum period result in the disruption of ongoing maternal behavior.
Positive_regulation (levels) of Positive_regulation (activation) of mu opioid receptor associated with mu opioid receptor
6) Confidence 0.45 Published 2000 Journal Physiol. Behav. Section Abstract Doc Link 10978498 Disease Relevance 0 Pain Relevance 0.39
These results suggest that an activation of opioid mu-receptor by loperamide can increase the utilization of glucose in peripheral tissue to lower the plasma glucose in STZ-diabetic rats.
Positive_regulation (increase) of Positive_regulation (activation) of mu-receptor in plasma associated with diabetes mellitus and opioid
7) Confidence 0.44 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10327161 Disease Relevance 0.33 Pain Relevance 0.51
These results indicate that the upregulation of mu opioid receptors as measured by radioligand binding is not accompanied by increased levels of mu receptor mRNA.
Positive_regulation (increased) of Positive_regulation (levels) of mu receptor mRNA associated with mu opioid receptor
8) Confidence 0.43 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750897 Disease Relevance 0 Pain Relevance 0.60
The hippocampal formation is a brain region sensitive to seizure development, a phenomenon thought to be mediated in part by mu-opioid receptor (MOR) activation.
Positive_regulation (mediated) of in brain Positive_regulation (activation) of mu-opioid receptor in hippocampal formation associated with convulsion and opioid receptor
9) Confidence 0.40 Published 2003 Journal Exp. Neurol. Section Abstract Doc Link 12618127 Disease Relevance 0.52 Pain Relevance 0.29
To investigate the functional role of G protein-coupled receptor kinases (GRK) in homologous desensitization of the mu-opioid receptor, human embryonic kidney (HEK) 293 cells, which express a significant level of GRK2, were stably transfected with the cDNA encoding the rat mu-opioid receptor.
Spec (investigate) Positive_regulation (role) of Positive_regulation (desensitization) of mu-opioid receptor in embryonic kidney associated with opioid receptor
10) Confidence 0.39 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10698001 Disease Relevance 0 Pain Relevance 0.36
Together with previous studies, the inhibition of the neuronal activity induced by mu-opioid receptor activation may activate descending antinociceptive pathways through a GABAergic disinhibitory mechanism and depress the nociceptive information transmission at the level of the spinal cord.
Positive_regulation (induced) of Positive_regulation (activation) of mu-opioid receptor in neuronal associated with nociception, gabaergic, opioid receptor, antinociceptive and spinal cord
11) Confidence 0.38 Published 2009 Journal Neuroscience Section Abstract Doc Link 19341781 Disease Relevance 0.35 Pain Relevance 0.69
Increase in the extracellular histamine concentration in the rat striatum by mu-opioid receptor activation.
Positive_regulation (Increase) of Positive_regulation (activation) of mu-opioid receptor in striatum associated with enkephalin and opioid receptor
12) Confidence 0.37 Published 1994 Journal J. Neurochem. Section Title Doc Link 8294934 Disease Relevance 0 Pain Relevance 0.75
These results indicate a complex DAMGO modulation of the NMDA component of glutamatergic synaptic transmission in NAcc: mu receptor activation decreases NMDA-EPSP amplitudes presynaptically yet increases NMDA currents postsynaptically.
Positive_regulation (increases) of Positive_regulation (activation) of mu receptor in NAcc associated with nucleus accumbens
13) Confidence 0.37 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 8987732 Disease Relevance 0 Pain Relevance 0.69
In total, these data suggest that DOR mediates the antinociceptive response to deltorphin II, SNC80, and pCl-DPDPE at supraspinal sites and further demonstrates that the DOR-mediated response to deltorphin II and SNC80 is independent of mu-receptor activation.
Positive_regulation (response) of Positive_regulation (activation) of mu-receptor associated with opioid receptor and antinociceptive
14) Confidence 0.25 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11082450 Disease Relevance 0 Pain Relevance 1.25
ADP-ribosylation factor-dependent phospholipase D2 activation is required for agonist-induced mu-opioid receptor endocytosis.
Positive_regulation (required) of Positive_regulation (agonist-induced) of mu-opioid receptor associated with agonist and opioid receptor
15) Confidence 0.21 Published 2003 Journal J. Biol. Chem. Section Title Doc Link 12519790 Disease Relevance 0 Pain Relevance 0.48
[Cardiovascular effects of D-ALA2, LEU5, ARG6-enkephalin (dalargin) are mediated by peripheral mu-opioid receptor activation].
Positive_regulation (mediated) of Positive_regulation (activation) of mu-opioid receptor associated with opioid receptor and enkephalin
16) Confidence 0.19 Published 2008 Journal Eksp Klin Farmakol Section Title Doc Link 18488902 Disease Relevance 0.28 Pain Relevance 0.19
Agonist activation of the mu-opioid receptor stimulates a mitogen-activated protein kinase (MAPK) activity, but the functional significance of this pathway remains unclear.
Positive_regulation (stimulates) of Positive_regulation (activation) of mu-opioid receptor associated with agonist and opioid receptor
17) Confidence 0.16 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9575195 Disease Relevance 0 Pain Relevance 0.68
Buprenorphine activates mu and opioid receptor like-1 receptors simultaneously, but the analgesic effect is mainly mediated by mu receptor activation in the rat formalin test.
Positive_regulation (mediated) of Positive_regulation (activation) of mu receptor associated with analgesic, opioid receptor and buprenorphine
18) Confidence 0.08 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 16565164 Disease Relevance 0 Pain Relevance 1.52
We have established that mu-opioid receptor activation in the PAG causes a presynaptic inhibition of GABA release that is mediated by activation of a voltage-dependent K+ channel via 12-lipoxygenase (LOX) metabolites of arachidonic acid. 2.
Positive_regulation (mediated) of Positive_regulation (activation) of mu-opioid receptor associated with gaba, periaqueductal grey and opioid receptor
19) Confidence 0.04 Published 2000 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 10874510 Disease Relevance 0.53 Pain Relevance 1.18
Chronic mu-opioid receptor activation followed by removal of the agonist was previously shown, in transfected COS-7 cells, to induce superactivation of adenylyl cyclase type V.
Positive_regulation (superactivation) of Positive_regulation (activation) of mu-opioid receptor associated with agonist and opioid receptor
20) Confidence 0.03 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9030567 Disease Relevance 0 Pain Relevance 0.36

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