INT5855

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Context Info
Confidence 0.61
First Reported 1992
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 12
Total Number 16
Disease Relevance 12.26
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Bad) cell proliferation (Bad) cytosol (Bad)
mitochondrion (Bad) cytoplasm (Bad)
Anatomy Link Frequency
brain 2
cortex 1
hippocampus 1
Bad (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 8 99.90 Very High Very High Very High
Hippocampus 17 99.20 Very High Very High Very High
Dorsal horn 3 97.36 Very High Very High Very High
Inflammation 41 94.40 High High
trigeminal ganglion 3 94.24 High High
Morphine 6 94.00 High High
cytokine 8 85.44 High High
imagery 36 79.36 Quite High
withdrawal 11 77.80 Quite High
Opioid 3 71.64 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 356 100.00 Very High Very High Very High
Prostate Cancer 238 99.84 Very High Very High Very High
Cancer 177 98.84 Very High Very High Very High
Death 122 97.16 Very High Very High Very High
Congenital Anomalies 12 95.88 Very High Very High Very High
Cognitive Disorder 22 95.60 Very High Very High Very High
Encephalitis 16 94.40 High High
Ganglion Cysts 3 94.24 High High
Disease 267 92.92 High High
Prion Diseases 140 91.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These effects were associated with up-regulation of pro-apoptotic proteins such as Fas, FasL and Bad, in the cortex and hippocampus, indicating the activation of both the death receptor and the mitochondrial apoptotic pathways.
Positive_regulation (up-regulation) of Bad in hippocampus associated with hippocampus, apoptosis and death
1) Confidence 0.61 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18201731 Disease Relevance 0.80 Pain Relevance 0.12
To determine whether increased expression levels of BAD stimulate prostate tumor growth in vivo, we compared growth of C4-2Luc and C4-2LucBAD cells implanted in immunocompromised mice.
Spec (whether) Positive_regulation (increased) of BAD associated with prostate cancer
2) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 0.83 Pain Relevance 0.04
Combination of proliferative and apoptotic properties prompts prostate cancer cells to be “addicted” to increased levels of phosphorylated BAD.
Positive_regulation (increased) of BAD associated with prostate cancer and apoptosis
3) Confidence 0.40 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2704953 Disease Relevance 1.33 Pain Relevance 0
It appears contradictory that instead of limiting expression of pro-apoptotic protein, prostate cancer cells choose to increase BAD levels while keeping it under tight phosphorylation control.
Positive_regulation (increase) of BAD associated with prostate cancer and apoptosis
4) Confidence 0.40 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2704953 Disease Relevance 1.28 Pain Relevance 0
If so, high levels of phosphorylated BAD could be used to identify patients who will benefit from therapy with such inhibitors.
Positive_regulation (levels) of BAD
5) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 0.46 Pain Relevance 0
Cells with elevated levels of BAD were characterized by increased proliferation in tissue culture (Fig. 1A, B).
Positive_regulation (elevated) of BAD
6) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 0.41 Pain Relevance 0.03
This combination of proliferative and apoptotic properties creates conditions for prostate cancer cells “addiction” to increased levels of phosphorylated BAD.
Positive_regulation (increased) of BAD associated with addiction, prostate cancer and apoptosis
7) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 1.20 Pain Relevance 0.08
Increased levels of BAD in prostate carcinomas have also been reported.
Positive_regulation (Increased) of BAD associated with prostate cancer
8) Confidence 0.40 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2704953 Disease Relevance 1.01 Pain Relevance 0
Treatment also led to a significant increase in the brain levels of the CaN downstream targets pCREB and pBAD, which paralleled the decrease of CaN activity.
Positive_regulation (increase) of pBAD in brain
9) Confidence 0.24 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2951383 Disease Relevance 0.74 Pain Relevance 0
FK506 treatment does not alter PrPSc accumulation, but increases pCREB and pBAD
Neg (not) Positive_regulation (increases) of pBAD
10) Confidence 0.24 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2951383 Disease Relevance 0.17 Pain Relevance 0.03
These effects were associated with up-regulation of pro-apoptotic proteins such as Fas, FasL and Bad, in the cortex and hippocampus, indicating the activation of both the death receptor and the mitochondrial apoptotic pathways.
Positive_regulation (up-regulation) of Bad in cortex associated with hippocampus, apoptosis and death
11) Confidence 0.21 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18201731 Disease Relevance 0.80 Pain Relevance 0.12
Optimum activity of CaN is required to maintain the proper phosphorylation state of different important targets, like apoptosis inducer BAD or transcription factor CREB.
Positive_regulation (inducer) of BAD associated with apoptosis
12) Confidence 0.20 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2951383 Disease Relevance 0.42 Pain Relevance 0
This neurotoxic effect was accompanied by up-regulation of the proapoptotic proteins FasL, Fas, and Bad and the active fragments of caspases-8 and -3 in cortical and hippocampal lysates.
Positive_regulation (up-regulation) of Bad
13) Confidence 0.18 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16496378 Disease Relevance 0.50 Pain Relevance 0.59
Treatment with FK506 led to a significant increase of pCREB and pBAD levels in the brain, which paralleled the decrease of CaN activity.
Positive_regulation (increase) of pBAD in brain
14) Confidence 0.16 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2951383 Disease Relevance 0.59 Pain Relevance 0.05
CAT activity conferred by this promoter displayed trans-synaptic upregulation with both stimuli.
Positive_regulation (upregulation) of promoter
15) Confidence 0.02 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1317494 Disease Relevance 0.41 Pain Relevance 0.46
The Bcl-2 family includes pro-apoptotic (Bax and Bad) and anti-apoptotic (Bcl-2 and Bcl-XL) proteins, whose expression and activity is regulated through different signaling pathways including trophic factors deprivation, A?
Positive_regulation (apoptotic) of Bad associated with apoptosis
16) Confidence 0.02 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 1.33 Pain Relevance 0.04

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