INT58550

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Context Info
Confidence 0.43
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 0.99
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (SON) nucleolus (SON) RNA binding (SON)
nucleus (SON) intracellular (SON) DNA binding (SON)
Anatomy Link Frequency
hypothalamus 3
neurons 1
brain 1
PVN 1
SON (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 75 99.98 Very High Very High Very High
Dynorphin 6 95.56 Very High Very High Very High
Enkephalin 3 88.28 High High
agonist 16 84.72 Quite High
Central nervous system 16 79.36 Quite High
Somatostatin 4 70.56 Quite High
Intracerebroventricular 8 65.00 Quite High
neuropeptide release 4 24.84 Low Low
anesthesia 8 5.00 Very Low Very Low Very Low
isoflurane 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Volume Depletion And Dehydration 4 99.74 Very High Very High Very High
Cognitive Disorder 19 98.20 Very High Very High Very High
Stress 20 95.20 Very High Very High Very High
Communication Disorders 1 92.44 High High
Aggression 8 80.32 Quite High
Intellectual Impairment 5 77.68 Quite High
Pressure And Volume Under Development 4 67.84 Quite High
Increased Venous Pressure Under Development 4 57.44 Quite High
Systemic Lupus Erythematosus 2 29.20 Quite Low
Pressure Volume 2 Under Development 8 11.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The non-verbal development test SON-R produced encouraging results.
Gene_expression (produced) of SON-R
1) Confidence 0.43 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2921108 Disease Relevance 0.27 Pain Relevance 0
In the present study, a number of neurons or cells were activated with the expression of c-fos in both PVN and SON in the fetal hypothalamus following i.c.v. carbachol.
Gene_expression (expression) of SON in hypothalamus
2) Confidence 0.21 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570685 Disease Relevance 0 Pain Relevance 0.15
AVP and OT are two main neuropeptides synthesized by magnocellular neurosecretory neurons in the SON and PVN in the hypothalamus.
Gene_expression (synthesized) of SON in hypothalamus associated with neuropeptide
3) Confidence 0.18 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570685 Disease Relevance 0.06 Pain Relevance 0.23
However, i.c.v. carbachol produced intense FOS-ir in the fetal forebrain, including the SON and PVN in the hypothalamus (Figure 3 and 4).
Gene_expression (produced) of SON in hypothalamus
4) Confidence 0.18 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570685 Disease Relevance 0 Pain Relevance 0
Double labeling demonstrated that a number of AVP- and OT-containing neurons in the fetal SON and PVN were expressing c-fos in response to central carbachol.


Gene_expression (expressing) of SON in neurons
5) Confidence 0.16 Published 2008 Journal BMC Dev Biol Section Abstract Doc Link PMC2570685 Disease Relevance 0.07 Pain Relevance 0.11
However, neither isolation nor dehydration altered the expression of mRNA for vasopressin (AVP) in either the PVN or the SON.
Gene_expression (expression) of SON in PVN associated with volume depletion and dehydration
6) Confidence 0.04 Published 1993 Journal J. Mol. Endocrinol. Section Abstract Doc Link 8297474 Disease Relevance 0.52 Pain Relevance 0.39
We found that four of the five investigated genes, HBA, HBB, HBE and HEBP1, showed decreased expression levels in foxes selected for tameness compared to non-selected farm foxes.
Gene_expression (expression) of selected
7) Confidence 0.01 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1858698 Disease Relevance 0 Pain Relevance 0
We have previously compared the global brain gene expression of descendants of the selected (S) silver foxes with a group of non-selected (NS) foxes, raised under identical conditions in a Norwegian farm [11].
Gene_expression (expression) of selected in brain
8) Confidence 0.01 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1858698 Disease Relevance 0.08 Pain Relevance 0

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