INT58550

Context Info Confidence 0.43 First Reported 1993 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 8 Total Number 8 Disease Relevance 0.99 Pain Relevance 0.88

mRNA processing (SON) nucleolus (SON) RNA binding (SON) nucleus (SON) intracellular (SON) DNA binding (SON)

Anatomy Link Frequency hypothalamus 3 neurons 1 brain 1 PVN 1 SON (Homo sapiens)

Pain Link Frequency Relevance Heat Neuropeptide 75 99.98 Dynorphin 6 95.56 Enkephalin 3 88.28 agonist 16 84.72 Central nervous system 16 79.36 Somatostatin 4 70.56 Intracerebroventricular 8 65.00 neuropeptide release 4 24.84 anesthesia 8 5.00 isoflurane 8 5.00

Disease Link Frequency Relevance Heat Volume Depletion And Dehydration 4 99.74 Cognitive Disorder 19 98.20 Stress 20 95.20 Communication Disorders 1 92.44 Aggression 8 80.32 Intellectual Impairment 5 77.68 Pressure And Volume Under Development 4 67.84 Increased Venous Pressure Under Development 4 57.44 Systemic Lupus Erythematosus 2 29.20 Pressure Volume 2 Under Development 8 11.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The non-verbal development test SON-R produced encouraging results.

Gene_expression (produced) of SON-R

1) Confidence 0.43 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2921108 Disease Relevance 0.27 Pain Relevance 0

In the present study, a number of neurons or cells were activated with the expression of c-fos in both PVN and SON in the fetal hypothalamus following i.c.v. carbachol.

Gene_expression (expression) of SON in hypothalamus

2) Confidence 0.21 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570685 Disease Relevance 0 Pain Relevance 0.15

AVP and OT are two main neuropeptides synthesized by magnocellular neurosecretory neurons in the SON and PVN in the hypothalamus.

Gene_expression (synthesized) of SON in hypothalamus associated with neuropeptide

3) Confidence 0.18 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570685 Disease Relevance 0.06 Pain Relevance 0.23

However, i.c.v. carbachol produced intense FOS-ir in the fetal forebrain, including the SON and PVN in the hypothalamus (Figure 3 and 4).

Gene_expression (produced) of SON in hypothalamus

4) Confidence 0.18 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570685 Disease Relevance 0 Pain Relevance 0

Double labeling demonstrated that a number of AVP- and OT-containing neurons in the fetal SON and PVN were expressing c-fos in response to central carbachol.

Gene_expression (expressing) of SON in neurons

5) Confidence 0.16 Published 2008 Journal BMC Dev Biol Section Abstract Doc Link PMC2570685 Disease Relevance 0.07 Pain Relevance 0.11

However, neither isolation nor dehydration altered the expression of mRNA for vasopressin (AVP) in either the PVN or the SON.

Gene_expression (expression) of SON in PVN associated with volume depletion and dehydration

6) Confidence 0.04 Published 1993 Journal J. Mol. Endocrinol. Section Abstract Doc Link 8297474 Disease Relevance 0.52 Pain Relevance 0.39

We found that four of the five investigated genes, HBA, HBB, HBE and HEBP1, showed decreased expression levels in foxes selected for tameness compared to non-selected farm foxes.

Gene_expression (expression) of selected

7) Confidence 0.01 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1858698 Disease Relevance 0 Pain Relevance 0

We have previously compared the global brain gene expression of descendants of the selected (S) silver foxes with a group of non-selected (NS) foxes, raised under identical conditions in a Norwegian farm [11].

Gene_expression (expression) of selected in brain

8) Confidence 0.01 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1858698 Disease Relevance 0.08 Pain Relevance 0

General Comments

This test has worked.