INT58563

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Context Info
Confidence 0.51
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 11.75
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (S100B) extracellular region (S100B) nucleus (S100B)
cytoplasm (S100B)
Anatomy Link Frequency
neural crest 1
fat 1
S100B (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 9 99.44 Very High Very High Very High
corticosteroid 1 99.20 Very High Very High Very High
Inflammation 42 96.88 Very High Very High Very High
agonist 106 96.00 Very High Very High Very High
Glutamate 5 95.84 Very High Very High Very High
antagonist 4 94.64 High High
fluoxetine 1 92.08 High High
Catecholamine 2 91.36 High High
Serotonin 2 84.20 Quite High
cytokine 5 83.76 Quite High
Disease Link Frequency Relevance Heat
Sepsis 82 99.84 Very High Very High Very High
Skin Cancer 11 99.46 Very High Very High Very High
Cv General 4 Under Development 7 99.44 Very High Very High Very High
Cancer 67 99.40 Very High Very High Very High
Neuromyelitis Optica 14 99.40 Very High Very High Very High
Heart Rate Under Development 6 99.30 Very High Very High Very High
Stress 22 98.86 Very High Very High Very High
Disease 73 98.24 Very High Very High Very High
Nerve Sheath Neoplasms 2 97.68 Very High Very High Very High
Melanoma 4 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stress doses, as given in our patients, have not been shown to reduce serum S100B in septic shock [23].
Negative_regulation (reduce) of S100B associated with stress and sepsis
1) Confidence 0.51 Published 2010 Journal Crit Care Section Body Doc Link PMC2887172 Disease Relevance 1.43 Pain Relevance 0.10
Besides, studies have also documented the reduction of S100B in the presence of corticosteroids [75, 76].
Negative_regulation (reduction) of S100B associated with corticosteroid
2) Confidence 0.48 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2896837 Disease Relevance 0.61 Pain Relevance 0.17
The decrease in S100B in DrotAA-treated patients was not paralleled by a decrease in mortality.
Negative_regulation (decrease) of S100B
3) Confidence 0.44 Published 2010 Journal Crit Care Section Body Doc Link PMC2887172 Disease Relevance 1.25 Pain Relevance 0.18
At the differentiated stage, 1 muM MeHgCl induced selective loss of S100 beta-expressing astrocytic cells.
Negative_regulation (loss) of S100
4) Confidence 0.43 Published 2009 Journal Stem Cells Section Abstract Doc Link 19609937 Disease Relevance 0.55 Pain Relevance 0.28
We conclude that landiolol can be effectively used in the treatment of tachycardia in SAH patients and significantly reduced the serum S-100beta levels 24 hours after the operation.
Negative_regulation (reduced) of S-100beta associated with heart rate under development and cva
5) Confidence 0.42 Published 2010 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 20118792 Disease Relevance 0.79 Pain Relevance 0.33
The reduction of S100beta observed in r-NMO patients was not significant compared to controls; and no differences were present regarding IgG-NMO immunoreactivity.
Negative_regulation (reduction) of S100beta associated with neuromyelitis optica
6) Confidence 0.42 Published 2010 Journal Neuroimmunomodulation Section Abstract Doc Link 20134196 Disease Relevance 1.51 Pain Relevance 0.20
Lack of S-100 and HMB-45 ruled out the possibilities of an epithelioid MPNST and a melanoma.
Negative_regulation (Lack) of S-100 associated with nerve sheath neoplasms and melanoma
7) Confidence 0.42 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1820783 Disease Relevance 2.23 Pain Relevance 0
Thus when 5-HT was reduced by PCPA treatment, S100 beta immunoreactivity was also reduced.
Negative_regulation (reduced) of S100 beta
8) Confidence 0.42 Published 1993 Journal Brain Res. Section Abstract Doc Link 8298984 Disease Relevance 0 Pain Relevance 0.17
No autotransfusion was used in this study, however reabsorbtion of S100B from injured fat tissue may contribute to the measured serum levels of S100B.
Negative_regulation (reabsorbtion) of S100B in fat
9) Confidence 0.37 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544890 Disease Relevance 0.06 Pain Relevance 0
Within cNEUPRO, S100B was measured in 54 CSF samples from patients with sCJD, AD, and control patients with the use of a commercial ELISA.
Negative_regulation (measured) of S100B associated with disease
10) Confidence 0.26 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2945639 Disease Relevance 0.94 Pain Relevance 0
Both CCSTA and malignant melanoma are immunohistochemically positive for S-100 protein (a marker for tumors derived from neural crest) and HMB-45 (a marker identifying tumors associated with melanoma) [18] suggesting that these tumors have a close relationship.
Negative_regulation (positive) of S-100 protein in neural crest associated with cancer and skin cancer
11) Confidence 0.19 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1555585 Disease Relevance 1.59 Pain Relevance 0
Median S-100B serum levels of the hydrocortisone group decreased from 0.32 ng/mL at study entry to 0.07 ng/mL 6 days later without significant differences compared to the placebo group.
Negative_regulation (decreased) of S-100B
12) Confidence 0.15 Published 2005 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 15843228 Disease Relevance 0.79 Pain Relevance 0.09
Whilst there was no change in the overall level of Rab5 protein expression over the duration of cicaprost stimulation, there was a significant decrease in the levels of Rab5 in the S100 fraction as early as 30 min, which continued to decrease to barely detectable levels at 2–3 h post agonist stimulation (Figs. 4A and B).
Negative_regulation (decrease) of S100 associated with agonist
13) Confidence 0.10 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.24

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