INT5858

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Context Info
Confidence 0.69
First Reported 1985
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 66
Total Number 80
Disease Relevance 4.51
Pain Relevance 51.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Drd1a) plasma membrane (Drd1a) nucleus (Drd1a)
intracellular (Drd1a) signal transducer activity (Drd1a)
Anatomy Link Frequency
neurons 19
nucleus accumbens 4
PFC 3
caudate nucleus 2
striatum 2
Drd1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 2350 100.00 Very High Very High Very High
dopamine receptor 463 100.00 Very High Very High Very High
cocaine 18 100.00 Very High Very High Very High
agonist 509 99.96 Very High Very High Very High
Enkephalin 36 99.92 Very High Very High Very High
nMDA receptor 29 99.92 Very High Very High Very High
Morphine 217 99.90 Very High Very High Very High
opiate 7 99.90 Very High Very High Very High
Opioid 19 99.82 Very High Very High Very High
substance P 6 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Natriuresis 12 99.74 Very High Very High Very High
Shock 1 99.64 Very High Very High Very High
Movement Disorders 28 99.04 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 54 98.24 Very High Very High Very High
Targeted Disruption 28 97.64 Very High Very High Very High
Depression 45 95.48 Very High Very High Very High
Vibrio Infection 2 95.44 Very High Very High Very High
Hypertension 27 94.72 High High
Cognitive Disorder 20 92.16 High High
Eating Disorder 8 91.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of renal dopamine-1 receptors decreases sodium transport.
Positive_regulation (Activation) of dopamine-1 associated with dopamine
1) Confidence 0.69 Published 1990 Journal Hypertension Section Abstract Doc Link 1971811 Disease Relevance 0.40 Pain Relevance 0.31
The results obtained indicate that DA induces acid secretion via activation of the dopamine D1 receptor, located on the cholinergic neurons and on some nonneuronal cells, in the rat stomach.
Positive_regulation (activation) of dopamine D1 receptor in cholinergic neurons associated with dopamine
2) Confidence 0.68 Published 1995 Journal Neurosci. Res. Section Abstract Doc Link 7753504 Disease Relevance 0 Pain Relevance 0.49
When combined, the individual effects of D1 receptor activation in the NASh and VTA on the affective signs of precipitated morphine withdrawal resemble those seen with systemic administration.


Positive_regulation (activation) of D1 receptor in NASh
3) Confidence 0.68 Published 2009 Journal Psychopharmacology (Berl.) Section Body Doc Link 19148621 Disease Relevance 0 Pain Relevance 0
Collectively, these findings demonstrate that dopaminergic inputs to the nucleus accumbens are critically involved in opioid-induced immunosuppression and suggest that opioid-induced increases in D1 receptor activation may have adverse consequences on immune status.
Positive_regulation (increases) of D1 receptor in nucleus accumbens associated with nucleus accumbens and opioid
4) Confidence 0.68 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16364456 Disease Relevance 0 Pain Relevance 1.06
The major changes found were an increased D-1 receptor stimulated cAMP production and an enhanced release of noradrenaline in morphine treated rats and a decreased D-1 receptor stimulated cAMP production in naltrexone treated rats.
Positive_regulation (increased) of D-1 receptor associated with noradrenaline and morphine
5) Confidence 0.68 Published 1993 Journal Life Sci. Section Abstract Doc Link 8388977 Disease Relevance 0 Pain Relevance 1.01
The adenosine 3',5'-cyclic monophosphate analogue, 8-bromo-adenosine 3',5'-cyclic monophosphate (0.1-1 mM), mimicked the effects produced by D1 receptor activation.
Positive_regulation (activation) of D1 receptor associated with adenocard
6) Confidence 0.67 Published 1987 Journal Neuroscience Section Abstract Doc Link 2955246 Disease Relevance 0 Pain Relevance 0.63
This adaptive increase in D-1 receptor efficacy upon long-term mu-opioid receptor activation was about doubled after simultaneous or previous exposure of the neurons to the glucocorticoid receptor agonist dexamethasone (EC50 about 2 nM).
Positive_regulation (increase) of D-1 receptor in neurons associated with agonist, opioid receptor and dexamethasone
7) Confidence 0.63 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7562482 Disease Relevance 0 Pain Relevance 0.70
In chronic alcoholized rats SKF 38,393 increased the D1 receptor answer in biochemical and behavioural experiments.
Positive_regulation (increased) of D1 receptor
8) Confidence 0.60 Published 1995 Journal Pharmazie Section Abstract Doc Link 8584559 Disease Relevance 0.08 Pain Relevance 0.29
We suggest that the diminished natriuretic response to D1 receptor activation in OZR is the consequence of the previously reported defect in the D1 receptor-G-protein coupling and the failure of dopamine to inhibit the sodium transporters in these animals.
Positive_regulation (activation) of D1 receptor associated with natriuresis and dopamine
9) Confidence 0.59 Published 2003 Journal Clin. Exp. Hypertens. Section Abstract Doc Link 14649308 Disease Relevance 0.61 Pain Relevance 0.26
Such an enduring increase in postsynaptic D-1 receptor efficacy also occurred in cultured gamma-aminobutyric acid (GABA) neurons of the striatum obtained from rats prenatally treated with morphine.
Positive_regulation (increase) of D-1 receptor in neurons associated with gaba and morphine
10) Confidence 0.59 Published 1996 Journal Neurochem. Res. Section Abstract Doc Link 8947932 Disease Relevance 0 Pain Relevance 0.67
Morphine-induced increase in D-1 receptor regulated signal transduction in rat striatal neurons and its facilitation by glucocorticoid receptor activation: possible role in behavioral sensitization.
Spec (possible) Positive_regulation (increase) of D-1 receptor in neurons associated with morphine
11) Confidence 0.59 Published 1996 Journal Neurochem. Res. Section Title Doc Link 8947932 Disease Relevance 0 Pain Relevance 0.66
These data show that the morphine-induced adaptive increase of postsynaptic dopamine D-1 receptor efficacy (also observed in striatal slices of rats weeks after repeated treatment with morphine or cocaine) is strongly enhanced after previous or simultaneous glucocorticoid receptor activation.
Positive_regulation (increase) of D-1 receptor associated with dopamine, cocaine and morphine
12) Confidence 0.55 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7562482 Disease Relevance 0 Pain Relevance 1.05
Glucocorticoid receptor activation potentiates the morphine-induced adaptive increase in dopamine D-1 receptor efficacy in gamma-aminobutyric acid neurons of rat striatum/nucleus accumbens.
Positive_regulation (increase) of D-1 receptor in neurons associated with nucleus accumbens, dopamine and morphine
13) Confidence 0.55 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 7562482 Disease Relevance 0 Pain Relevance 0.66
One month (but not 1-3 days) after intermittent morphine administration, the hyperresponsiveness of rats toward the locomotor effects of morphine and amphetamine was associated with an increase in dopamine (DA) D-1 receptor-stimulated adenylyl cyclase activity and enhanced steady state levels of preprodynorphin gene expression in slices of the caudate/putamen and nucleus accumbens.
Positive_regulation (increase) of D-1 receptor in nucleus accumbens associated with nucleus accumbens, dopamine and morphine
14) Confidence 0.51 Published 1996 Journal Neurochem. Res. Section Abstract Doc Link 8947932 Disease Relevance 0 Pain Relevance 0.59
One month (but not 1-3 days) after intermittent morphine administration, the hyperresponsiveness of rats toward the locomotor effects of morphine and amphetamine was associated with an increase in dopamine (DA) D-1 receptor-stimulated adenylyl cyclase activity and enhanced steady state levels of preprodynorphin gene expression in slices of the caudate/putamen and nucleus accumbens.
Positive_regulation (stimulated) of D-1 receptor in nucleus accumbens associated with nucleus accumbens, dopamine and morphine
15) Confidence 0.51 Published 1996 Journal Neurochem. Res. Section Abstract Doc Link 8947932 Disease Relevance 0 Pain Relevance 0.59
These results strongly implicate the role of dopamine D1 activation in morphine-induced stereotypies.
Positive_regulation (activation) of dopamine D1 associated with dopamine and morphine
16) Confidence 0.50 Published 1989 Journal Neurosci. Lett. Section Abstract Doc Link 2682389 Disease Relevance 0 Pain Relevance 0.84
Activation of GR by corticosterone did not facilitate the increase in D1 receptor efficacy induced by sustained activation of muscarinic receptors in cultured striatal neurons.
Positive_regulation (induced) of D1 receptor in neurons
17) Confidence 0.49 Published 1997 Journal Synapse Section Abstract Doc Link 9097397 Disease Relevance 0 Pain Relevance 0.80
Activation of GR by corticosterone did not facilitate the increase in D1 receptor efficacy induced by sustained activation of muscarinic receptors in cultured striatal neurons.
Positive_regulation (increase) of D1 receptor in neurons
18) Confidence 0.49 Published 1997 Journal Synapse Section Abstract Doc Link 9097397 Disease Relevance 0 Pain Relevance 0.80
The major changes found were an increased D-1 receptor stimulated cAMP production and an enhanced release of noradrenaline in morphine treated rats and a decreased D-1 receptor stimulated cAMP production in naltrexone treated rats.
Positive_regulation (increased) of D-1 receptor associated with noradrenaline and morphine
19) Confidence 0.49 Published 1993 Journal Life Sci. Section Abstract Doc Link 8388977 Disease Relevance 0 Pain Relevance 1.01
Striatal neurons that express the D-1 DA receptor coexpress dynorphin and substance P, and CREB is known to couple D-1 DA receptor stimulation to preprodynorphin (ppD) gene expression.
Positive_regulation (stimulation) of D-1 DA receptor in neurons associated with dopamine, dynorphin and substance p
20) Confidence 0.47 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 16257473 Disease Relevance 0.08 Pain Relevance 0.78

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