INT58581

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Context Info
Confidence 0.44
First Reported 1994
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 1.68
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RPA1) chromosome organization (RPA1) nucleolus (RPA1)
nucleus (RPA1) DNA binding (RPA1) cytoplasm (RPA1)
Anatomy Link Frequency
CNS 1
RPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 4 99.76 Very High Very High Very High
antagonist 20 97.64 Very High Very High Very High
Central nervous system 20 95.44 Very High Very High Very High
Morphine 6 90.40 High High
Migraine 19 61.52 Quite High
Multiple sclerosis 6 52.08 Quite High
addiction 3 46.00 Quite Low
tolerance 3 45.40 Quite Low
Analgesic 4 25.00 Low Low
headache 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 9 97.16 Very High Very High Very High
Epilepsy 16 96.32 Very High Very High Very High
Vascular Dementia 5 95.92 Very High Very High Very High
Disease 25 95.28 Very High Very High Very High
Motor Neuron Diseases 11 94.68 High High
Alzheimer's Dementia 10 93.12 High High
Brain Tumor 5 77.04 Quite High
Headache 22 61.52 Quite High
Vertigo 19 60.72 Quite High
Cancer 4 59.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Characterization of a nuclear factor that enhances DNA binding activity of SSCRE-BP/PUR alpha, a single-stranded DNA binding protein.
single-stranded DNA binding protein Binding (binding) of
1) Confidence 0.44 Published 1997 Journal Neurochem. Int. Section Title Doc Link 9185164 Disease Relevance 0 Pain Relevance 0.09
Characterization of a nuclear factor that enhances DNA binding activity of SSCRE-BP/PUR alpha, a single-stranded DNA binding protein.
single-stranded DNA binding protein Binding (activity) of
2) Confidence 0.33 Published 1997 Journal Neurochem. Int. Section Title Doc Link 9185164 Disease Relevance 0 Pain Relevance 0.09
Pur alpha has been identified as a single-stranded DNA binding protein that specifically binds to the purine-rich strand present in the DNA replication initiation zone of the human c-myc gene.
single-stranded DNA binding protein Binding (binds) of
3) Confidence 0.33 Published 1997 Journal Neurochem. Int. Section Abstract Doc Link 9185164 Disease Relevance 0 Pain Relevance 0.09
Despite the fact that the emission from mobile phones is a combination of RF-EMF and pulsed ELF-EMF [13], no studies have investigated the association between use of mobile phones and risks for CNS disease.
RF-EMF Binding (combination) of in CNS associated with central nervous system and disease
4) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2632742 Disease Relevance 1.68 Pain Relevance 0.33
In addition, a nearby residue, histidine 265 of the human receptor, is required for the binding of RP67580 but not CP-96,345 or substance P.
RP67580 Binding (binding) of associated with substance p
5) Confidence 0.01 Published 1994 Journal J. Biol. Chem. Section Abstract Doc Link 8300604 Disease Relevance 0 Pain Relevance 0.20
Histidine 197 in the human receptor was found to interact with CP-96,345 but not RP67580.
RP67580 Binding (interact) of
6) Confidence 0.01 Published 1994 Journal J. Biol. Chem. Section Abstract Doc Link 8300604 Disease Relevance 0 Pain Relevance 0.17
The interaction between residue 265 and RP67580 is consistent with a hydrogen bonding interaction.
RP67580 Binding (interaction) of
7) Confidence 0.01 Published 1994 Journal J. Biol. Chem. Section Abstract Doc Link 8300604 Disease Relevance 0 Pain Relevance 0.23
The interaction between residue 265 and RP67580 is consistent with a hydrogen bonding interaction.
RP67580 Binding (interaction) of
8) Confidence 0.01 Published 1994 Journal J. Biol. Chem. Section Abstract Doc Link 8300604 Disease Relevance 0 Pain Relevance 0.23

General Comments

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