INT58589

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Context Info
Confidence 0.39
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.90
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (F12) extracellular space (F12) extracellular region (F12)
plasma membrane (F12)
Anatomy Link Frequency
plasma 1
F12 (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 1 94.96 High High
Inflammation 2 75.04 Quite High
bradykinin 23 58.80 Quite High
Pain score 1 27.40 Quite Low
Pain 6 16.76 Low Low
Antihistamine 11 5.00 Very Low Very Low Very Low
antagonist 9 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
abdominal pain 5 5.00 Very Low Very Low Very Low
b2 receptor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chills 1 95.84 Very High Very High Very High
Hereditary Angioedema 198 95.68 Very High Very High Very High
Headache 1 94.96 High High
Erythema 3 94.56 High High
Pressure And Volume Under Development 109 92.08 High High
Colon Cancer 1 77.88 Quite High
INFLAMMATION 2 75.04 Quite High
Disease 27 74.40 Quite High
Injury 2 74.36 Quite High
Infection 2 74.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By following a functional hypothesis that the genetic defect might be located in the coagulation factor XII (FXII) gene the factor XII gene on chromosome 5 was then selectively investigated [11].
Regulation (coagulation) of factor XII
1) Confidence 0.39 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2919521 Disease Relevance 0.72 Pain Relevance 0
C1 INH, prekallikrein, high-molecular-weight kininogen, and factor XII levels in plasma were not influenced by the rHuIFN-gamma administration.
Neg (not) Regulation (influenced) of factor XII in plasma
2) Confidence 0.06 Published 1994 Journal J. Lab. Clin. Med. Section Abstract Doc Link 8301199 Disease Relevance 0.64 Pain Relevance 0.09
C1-inhibitor also may play a minor role in the regulation of the coagulation cascade by means of its inhibitory effects on factor XIIa and factor XIa, as well as on thrombin formation [1,2,18,20,21].
Regulation (effects) of factor XIIa
3) Confidence 0.02 Published 2008 Journal Clin Mol Allergy Section Body Doc Link PMC2374835 Disease Relevance 0.53 Pain Relevance 0.07

General Comments

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