INT5859

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Context Info
Confidence 0.55
First Reported 1991
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 20
Total Number 24
Disease Relevance 2.05
Pain Relevance 15.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Drd1a) plasma membrane (Drd1a) nucleus (Drd1a)
intracellular (Drd1a) signal transducer activity (Drd1a)
Anatomy Link Frequency
neurons 8
nucleus accumbens 3
pyramidal cells 2
caudate nucleus 2
striatum 2
Drd1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 769 100.00 Very High Very High Very High
agonist 175 100.00 Very High Very High Very High
dopamine receptor 160 100.00 Very High Very High Very High
gABA 153 100.00 Very High Very High Very High
Morphine 46 100.00 Very High Very High Very High
nMDA receptor 21 100.00 Very High Very High Very High
cocaine 2 100.00 Very High Very High Very High
Intracerebroventricular 1 99.80 Very High Very High Very High
opiate 1 99.76 Very High Very High Very High
substance P 3 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Shock 1 100.00 Very High Very High Very High
Natriuresis 6 99.98 Very High Very High Very High
Depression 28 95.48 Very High Very High Very High
Eating Disorder 1 91.92 High High
Nociception 33 80.32 Quite High
Obesity 3 79.84 Quite High
Schizophrenia 3 79.28 Quite High
Disease 116 78.56 Quite High
Li-fraumeni Syndrome 22 78.48 Quite High
Diuresis 1 49.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data show that the morphine-induced adaptive increase of postsynaptic dopamine D-1 receptor efficacy (also observed in striatal slices of rats weeks after repeated treatment with morphine or cocaine) is strongly enhanced after previous or simultaneous glucocorticoid receptor activation.
Positive_regulation (enhanced) of Positive_regulation (increase) of D-1 receptor associated with dopamine, cocaine and morphine
1) Confidence 0.55 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7562482 Disease Relevance 0 Pain Relevance 1.06
One month (but not 1-3 days) after intermittent morphine administration, the hyperresponsiveness of rats toward the locomotor effects of morphine and amphetamine was associated with an increase in dopamine (DA) D-1 receptor-stimulated adenylyl cyclase activity and enhanced steady state levels of preprodynorphin gene expression in slices of the caudate/putamen and nucleus accumbens.
Positive_regulation (increase) of Positive_regulation (stimulated) of D-1 receptor in nucleus accumbens associated with nucleus accumbens, dopamine and morphine
2) Confidence 0.51 Published 1996 Journal Neurochem. Res. Section Abstract Doc Link 8947932 Disease Relevance 0 Pain Relevance 0.59
Activation of GR by corticosterone did not facilitate the increase in D1 receptor efficacy induced by sustained activation of muscarinic receptors in cultured striatal neurons.
Positive_regulation (increase) of Positive_regulation (induced) of D1 receptor in neurons
3) Confidence 0.49 Published 1997 Journal Synapse Section Abstract Doc Link 9097397 Disease Relevance 0 Pain Relevance 0.81
The results obtained indicate that DA induces acid secretion via activation of the dopamine D1 receptor, located on the cholinergic neurons and on some nonneuronal cells, in the rat stomach.
Positive_regulation (induces) of Positive_regulation (activation) of dopamine D1 receptor in cholinergic neurons associated with dopamine
4) Confidence 0.49 Published 1995 Journal Neurosci. Res. Section Abstract Doc Link 7753504 Disease Relevance 0 Pain Relevance 0.50
The major changes found were an increased D-1 receptor stimulated cAMP production and an enhanced release of noradrenaline in morphine treated rats and a decreased D-1 receptor stimulated cAMP production in naltrexone treated rats.
Positive_regulation (increased) of Positive_regulation (increased) of D-1 receptor associated with noradrenaline and morphine
5) Confidence 0.49 Published 1993 Journal Life Sci. Section Abstract Doc Link 8388977 Disease Relevance 0 Pain Relevance 1.01
We suggest that the diminished natriuretic response to D1 receptor activation in OZR is the consequence of the previously reported defect in the D1 receptor-G-protein coupling and the failure of dopamine to inhibit the sodium transporters in these animals.
Positive_regulation (response) of Positive_regulation (activation) of D1 receptor associated with natriuresis and dopamine
6) Confidence 0.43 Published 2003 Journal Clin. Exp. Hypertens. Section Abstract Doc Link 14649308 Disease Relevance 0.62 Pain Relevance 0.27
These data show that the morphine-induced adaptive increase of postsynaptic dopamine D-1 receptor efficacy (also observed in striatal slices of rats weeks after repeated treatment with morphine or cocaine) is strongly enhanced after previous or simultaneous glucocorticoid receptor activation.
Positive_regulation (morphine-induced) of Positive_regulation (increase) of D-1 receptor associated with dopamine, cocaine and morphine
7) Confidence 0.40 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7562482 Disease Relevance 0 Pain Relevance 1.06
Recently, it has been shown that intracerebroventricular (i.c.v.) injection of the D-1 DA receptor agonist, SKF-82958, produces an enhanced locomotor-activating effect as well as increased activation of striatal ERK 1/2 MAP kinase, CaM kinase II, CREB, and c-fos in food-restricted (FR) relative to ad libitum fed (AL) rats.
Positive_regulation (produces) of Positive_regulation (injection) of D-1 DA receptor associated with dopamine, agonist and intracerebroventricular
8) Confidence 0.39 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 16257473 Disease Relevance 0.09 Pain Relevance 0.63
We now report that, like zif268, krox-20 is rapidly and transiently activated by electroconvulsive shock treatment (ECT), D1 dopamine receptor activation, and opiate withdrawal.
Positive_regulation (activated) of Positive_regulation (activation) of D1 dopamine receptor associated with dopamine receptor, shock, opiate and withdrawal
9) Confidence 0.36 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1317498 Disease Relevance 0.10 Pain Relevance 0.20
Thus, the ability to use previously acquired spatial information to guide responding 30 min later on a radial arm maze requires D1 receptor activation in the PFC and D1 receptor modulation of hippocampal inputs to the PFC.
Positive_regulation (requires) of Positive_regulation (activation) of D1 receptor in PFC
10) Confidence 0.33 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9454866 Disease Relevance 0 Pain Relevance 0.25
The kappa opioid agonist, U69593, had no effect, probably due to low kappa receptor contents in rat caudate nucleus. 10(-4) M of the sigma receptor specific agonist, 1,3-di-o-tolylguanidine (DTG), potentiated the dopamine as well as the dopamine D1 stimulated adenylate cyclase while lower concentrations of DTG had no effect.
Neg (no) Positive_regulation (potentiated) of Positive_regulation (stimulated) of dopamine D1 in caudate nucleus associated with dopamine, mu agonist and agonist
11) Confidence 0.26 Published 1991 Journal Pharmacol. Toxicol. Section Abstract Doc Link 1666431 Disease Relevance 0 Pain Relevance 0.91
This effect depends upon an inhibitory feedback action of adenosine, liberated following facilitation of postsynaptic NMDA receptors by D1 receptor activation, an action independent of adenylyl cyclase stimulation or cyclic AMP-dependent protein kinase (PKA; Harvey, J., Lacey, M.G., 1997.
Positive_regulation (facilitation) of Positive_regulation (activation) of D1 receptor associated with adenocard and nmda receptor
12) Confidence 0.24 Published 1999 Journal Neuropharmacology Section Abstract Doc Link 10218863 Disease Relevance 0.08 Pain Relevance 0.72
However, it induced a decreased response to dopamine D1-receptor stimulation in the substance P mRNA levels in dorsal regions of the dopamine-depleted striatum.
Positive_regulation (induced) of Positive_regulation (stimulation) of D1-receptor in striatum associated with dopamine and substance p
13) Confidence 0.21 Published 2002 Journal Synapse Section Abstract Doc Link 11746728 Disease Relevance 0 Pain Relevance 0.93
Moreover, our data indicate that activation of G-protein-coupled dopamine D1 receptors also induces a transporter-mediated increase in spontaneous GABA release, but through a different mechanism of action, i.e., through cAMP-dependent inhibition of Na(+)/K(+)-ATPase, inducing accumulation of intracellular sodium, reversal of the GABA carrier, and potentiation of NMDA-induced release.
Positive_regulation (increase) of Positive_regulation (activation) of dopamine D1 associated with gaba and dopamine
14) Confidence 0.20 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10777812 Disease Relevance 0 Pain Relevance 1.10
Moreover, our data indicate that activation of G-protein-coupled dopamine D1 receptors also induces a transporter-mediated increase in spontaneous GABA release, but through a different mechanism of action, i.e., through cAMP-dependent inhibition of Na(+)/K(+)-ATPase, inducing accumulation of intracellular sodium, reversal of the GABA carrier, and potentiation of NMDA-induced release.
Positive_regulation (inducing) of Positive_regulation (activation) of dopamine D1 associated with gaba and dopamine
15) Confidence 0.20 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10777812 Disease Relevance 0 Pain Relevance 1.10
One month (but not 1-3 days) after intermittent morphine administration, the hyperresponsiveness of rats toward the locomotor effects of morphine and amphetamine was associated with an increase in dopamine (DA) D-1 receptor-stimulated adenylyl cyclase activity and enhanced steady state levels of preprodynorphin gene expression in slices of the caudate/putamen and nucleus accumbens.
Positive_regulation (increase) of in putamen Positive_regulation (stimulated) of D-1 receptor in nucleus accumbens associated with nucleus accumbens, dopamine and morphine
16) Confidence 0.17 Published 1996 Journal Neurochem. Res. Section Abstract Doc Link 8947932 Disease Relevance 0 Pain Relevance 0.59
D1 receptor activation can increase spiking in prefrontal neurons
Positive_regulation (increase) of Positive_regulation (activation) of D1 receptor in neurons
17) Confidence 0.11 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2519792 Disease Relevance 0 Pain Relevance 0.24
Postsynaptic dopamine receptor D1 activation reportedly enhances NMDA mediated-excitatory post-synaptic currents [34] and increases surface expression of NMDA receptors in pyramidal cells [35].
Positive_regulation (increases) of Positive_regulation (activation) of dopamine receptor D1 in pyramidal cells associated with pyramidal cell, nmda receptor and dopamine receptor
18) Confidence 0.10 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2936438 Disease Relevance 1.00 Pain Relevance 1.21
Increased GABA release upon activation of D1LRs was shown in microdialysis studies, and is also supported by electrophysiologic experiments (Floran et al., 1990; Timmerman and Westerink, 1995; Rosales et al., 1997; Radnikow and Misgeld, 1998; Matuszewich and Yamamoto, 1999; Trevitt et al., 2002; Acosta-Garcia et al., 2009).
Positive_regulation (Increased) of Positive_regulation (activation) of D1LRs associated with gaba
19) Confidence 0.06 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0 Pain Relevance 0.23
Not all studies have agreed that the activation of D1LRs increases GABA release and reduces the activity of neurons in the SNr.
Positive_regulation (increases) of Positive_regulation (activation) of D1LRs in neurons associated with gaba
20) Confidence 0.05 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0 Pain Relevance 0.38

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