INT58590

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Context Info
Confidence 0.84
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.75
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IFNG) extracellular region (IFNG)
Anatomy Link Frequency
fibroblasts 1
IFNG (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 1 70.92 Quite High
Calcium channel 1 51.60 Quite High
Potency 1 13.04 Low Low
Inflammation 6 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
peripheral neuropathy 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 1 88.16 High High
Gauchers Disease 68 87.48 High High
Pressure And Volume Under Development 2 79.92 Quite High
Erythema 1 71.32 Quite High
Headache 1 70.92 Quite High
Chills 1 69.96 Quite High
Disease 15 62.24 Quite High
Hereditary Angioedema 1 61.52 Quite High
Lysosome Storage Disease 1 49.96 Quite Low
Parkinson's Disease 8 30.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Administration of gamma interferon in human subjects decreases plasminogen activation and fibrinolysis without influencing C1 inhibitor.
Protein_catabolism (Administration) of gamma interferon
1) Confidence 0.84 Published 1994 Journal J. Lab. Clin. Med. Section Title Doc Link 8301199 Disease Relevance 0.50 Pain Relevance 0.07
Similarly G202R, a GC variant retained in the endoplasmic reticulum, is also shown to be amenable to chemical chaperoning.73 However, imino sugar derivatives are nonspecific and have relatively short half-lives in cells, and these molecules can inhibit other glycolipid and glycoprotein processing enzymes.74 Several studies have demonstrated that isofagomine (IFG), an imino sugar that binds to the active site, enhanced the folding, transport, and stability of several GC variants, including L444P.75 IFG was found to have little or no inhibitory activity against other glucosidases, and further treatment of wild type fibroblasts with high doses did not alter the processing of newly synthesized N-linked oligosaccharides.76 These findings supported the further evaluation of IFG as a potential therapeutic agent in GD.
Protein_catabolism (stability) of IFG in fibroblasts associated with gauchers disease
2) Confidence 0.29 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2909498 Disease Relevance 0.25 Pain Relevance 0.03

General Comments

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