INT58595

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Context Info
Confidence 0.47
First Reported 1994
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.53
Pain Relevance 3.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nkx1-1) neurological system process (Nkx1-1)
Anatomy Link Frequency
CoAO 1
spinal cord 1
muscle 1
dorsal root ganglia 1
Nkx1-1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spinal-cord stimulation 16 99.84 Very High Very High Very High
medulla 4 99.14 Very High Very High Very High
Spinal cord 43 99.08 Very High Very High Very High
ischemia 8 98.72 Very High Very High Very High
Dorsal horn 17 98.60 Very High Very High Very High
Angina 2 96.12 Very High Very High Very High
calcitonin gene related peptide 3 93.68 High High
substance P 19 92.96 High High
Dorsal horn neuron 3 92.28 High High
Glutamate receptor 4 90.40 High High
Disease Link Frequency Relevance Heat
Coronary Artery Disease 8 99.04 Very High Very High Very High
Increased Venous Pressure Under Development 8 97.60 Very High Very High Very High
Cv General 3 Under Development 2 96.12 Very High Very High Very High
Nociception 50 95.92 Very High Very High Very High
Pain 27 87.84 High High
Interstitial Cystitis 2 82.84 Quite High
Stress 10 78.56 Quite High
INFLAMMATION 7 76.80 Quite High
Nervous System Injury 1 74.84 Quite High
Hyperalgesia 4 40.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Only SP mRNA was increased significantly in T4 and brainstem during CoAO, while SCS decreased the mRNA levels of SP, NK-1 and TRPV1 significantly in T4 and the brainstem.
Transcription (levels) of NK-1 in CoAO associated with medulla and spinal-cord stimulation
1) Confidence 0.47 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17714867 Disease Relevance 0.39 Pain Relevance 0.74
The effect of high cervical spinal cord stimulation on the expression of SP, NK-1 and TRPV1 mRNAs during cardiac ischemia in rat.
Transcription (expression) of NK-1 in spinal cord associated with coronary artery disease, ischemia and spinal-cord stimulation
2) Confidence 0.35 Published 2007 Journal Neurosci. Lett. Section Title Doc Link 17714867 Disease Relevance 0.41 Pain Relevance 0.72
Following injection of either formalin or complete Freund's adjuvant (CFA) into one hindpaw, the levels of expression of NK-1 and NK-3 mRNAs in the spinal cord dorsal horn and preprotachykinin (PPT) mRNA expression in the lumbar dorsal root ganglia (DRG) were quantitated using solution hybridization-nuclease protection assays.
Transcription (expression) of NK-1 in dorsal root ganglia associated with dorsal horn and spinal cord
3) Confidence 0.33 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 8301359 Disease Relevance 0.33 Pain Relevance 0.65
Expression of mRNA for CGRP1 receptors, muscarinic m2, m3 and m5 receptors and neurokinin1 (NK1) and NK3, receptors was detected.
Transcription (Expression) of NK1
4) Confidence 0.16 Published 2000 Journal Auton Neurosci Section Abstract Doc Link 11593767 Disease Relevance 0.54 Pain Relevance 0.44
Subsequently, CREB phosphorylated at serine133 (p-CREB) further induces transcription of genes containing cAMP response element (CRE) binding sites in their promoter regions [31], such as c-fos, NK-1, BDNF, and trkB [32-34].
Transcription (transcription) of NK-1
5) Confidence 0.14 Published 2007 Journal Mol Pain Section Body Doc Link PMC2174921 Disease Relevance 0.39 Pain Relevance 0.45
The activation of MAP kinase signaling was also reported to be involved in the transcriptional regulation of prodynorphin and neurokinin-1 (NK-1) gene products [5,14,16,35].
Transcription (transcriptional) of NK-1
6) Confidence 0.11 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0.39 Pain Relevance 0.53
RESULTS: Autoradiographic signal indicating the presence of NK1-encoding mRNA was localized to detrusor muscle, urothelium and vascular structures.
Transcription (presence) of NK1-encoding in muscle
7) Confidence 0.00 Published 1998 Journal Br J Urol Section Body Doc Link 9488063 Disease Relevance 0.08 Pain Relevance 0

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