INT58596

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Context Info
Confidence 0.49
First Reported 1994
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 21
Total Number 23
Disease Relevance 14.05
Pain Relevance 13.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nkx1-1) neurological system process (Nkx1-1)
Anatomy Link Frequency
spinal 8
neurons 6
lymphocytes 6
spinal cord dorsal horn 6
sensory neurons 4
Nkx1-1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 512 100.00 Very High Very High Very High
Pain 203 100.00 Very High Very High Very High
Spinal cord 123 100.00 Very High Very High Very High
Kinase C 85 100.00 Very High Very High Very High
tetrodotoxin 34 100.00 Very High Very High Very High
Dorsal horn 19 100.00 Very High Very High Very High
Rostral ventromedial medulla 4 100.00 Very High Very High Very High
Dynorphin 3 100.00 Very High Very High Very High
dorsal root ganglion 248 99.96 Very High Very High Very High
Antinociceptive 6 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Respiratory Syncytial Virus 32 99.98 Very High Very High Very High
Ganglion Cysts 255 99.96 Very High Very High Very High
Nociception 107 99.84 Very High Very High Very High
INFLAMMATION 278 99.32 Very High Very High Very High
Pain 205 98.84 Very High Very High Very High
Hyperalgesia 88 98.40 Very High Very High Very High
Arthritis 336 96.88 Very High Very High Very High
Hypersensitivity 19 96.64 Very High Very High Very High
Injury 20 96.48 Very High Very High Very High
Neuropathic Pain 55 92.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous work has demonstrated that persistent nociception evokes increased neurokinin-1 receptor (NK-1) gene expression in the spinal cord dorsal horn of the rat within 2 h but has failed to elucidate the relationship between increased NK-1 gene expression at later time points and functional regulation of NK-1 receptor signaling.
Positive_regulation (increased) of Gene_expression (expression) of NK-1 in spinal cord dorsal horn associated with nociception, dorsal horn and spinal cord
1) Confidence 0.49 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15985614 Disease Relevance 0.39 Pain Relevance 0.32
Activity of neurokinin-1 (NK-1) receptor-expressing ascending spinal neurons, descending pathways originating in the rostral ventromedial medulla (RVM), and spinal dynorphin are necessary for the development and maintenance of hyperalgesia during sustained morphine exposure, suggesting that these mechanisms may also be important in opioid enhancement of surgical pain.
Positive_regulation (necessary) of Gene_expression (expressing) of NK-1 in neurons associated with pain, hyperalgesia, dynorphin, opioid, morphine and rostral ventromedial medulla
2) Confidence 0.48 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19200067 Disease Relevance 0.81 Pain Relevance 1.00
Differential expression of NK1 and GABAB receptors in spinal neurones projecting to antinociceptive or pronociceptive medullary centres.
Positive_regulation (projecting) of Gene_expression (expression) of NK1 in spinal associated with nociceptor and antinociceptive
3) Confidence 0.37 Published 2006 Journal Brain Res. Bull. Section Title Doc Link 16564421 Disease Relevance 0.08 Pain Relevance 0.39
The present results suggest that the expression of NK1 and GABAB receptors varies in neurones participating to different spinofugal pathways.
Positive_regulation (varies) of Gene_expression (expression) of NK1
4) Confidence 0.37 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 16564421 Disease Relevance 0.07 Pain Relevance 0.33
Previous work has demonstrated that persistent nociception evokes increased neurokinin-1 receptor (NK-1) gene expression in the spinal cord dorsal horn of the rat within 2 h but has failed to elucidate the relationship between increased NK-1 gene expression at later time points and functional regulation of NK-1 receptor signaling.
Positive_regulation (increased) of Gene_expression (expression) of NK-1 in spinal cord dorsal horn associated with nociception, dorsal horn and spinal cord
5) Confidence 0.35 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15985614 Disease Relevance 0.32 Pain Relevance 0.27
RSV induced overexpression of the neurokinin 1 (NK1) receptor for substance P on discrete lymphocyte subpopulations within the bronchial-associated lymphoid tissue (BALT), and treatment with a specific NK1 receptor antagonist abolished the recruitment of both lymphocytes and monocytes to infected airways.
Positive_regulation (induced) of Gene_expression (overexpression) of NK1 in lymphocytes associated with antagonist, respiratory syncytial virus and substance p
6) Confidence 0.26 Published 2003 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 12639840 Disease Relevance 0.89 Pain Relevance 0.21
RSV induced overexpression of the neurokinin 1 (NK1) receptor for substance P on discrete lymphocyte subpopulations within the bronchial-associated lymphoid tissue (BALT), and treatment with a specific NK1 receptor antagonist abolished the recruitment of both lymphocytes and monocytes to infected airways.
Positive_regulation (overexpression) of Gene_expression (overexpression) of NK1 in lymphocytes associated with antagonist, respiratory syncytial virus and substance p
7) Confidence 0.26 Published 2003 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 12639840 Disease Relevance 0.89 Pain Relevance 0.21
These results suggest that although most NK1 receptor-expressing spinoparabrachial neurons are activated by noxious stimuli, responsiveness to noxious cold is significantly more common in those of the multipolar type.
Positive_regulation (activated) of Gene_expression (expressing) of NK1 in neurons
8) Confidence 0.25 Published 2005 Journal Neuroscience Section Abstract Doc Link 15680704 Disease Relevance 0.07 Pain Relevance 0.28
NK-1 and NK-3 type tachykinin receptor mRNA expression in the rat spinal cord dorsal horn is increased during adjuvant or formalin-induced nociception.
Positive_regulation (increased) of Gene_expression (expression) of NK-1 in spinal cord dorsal horn associated with nociception, pain, dorsal horn and spinal cord
9) Confidence 0.23 Published 1994 Journal J. Neurosci. Section Title Doc Link 8301359 Disease Relevance 0.35 Pain Relevance 0.71
These data support the hypothesis that transcription factor pCREB contributes to increased expression of spinal NK1 receptors during persistent pain.
Positive_regulation (increased) of Gene_expression (expression) of NK1 in spinal associated with pain and lasting pain
10) Confidence 0.17 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10729626 Disease Relevance 0.17 Pain Relevance 0.21
Data indicate that a possible mechanism for this effect is a GABA(B) receptor-induced blockade of neurokinin-1 (NK-1) receptor gene expression in the spinal cord.
Spec (possible) Positive_regulation (induced) of Gene_expression (expression) of NK-1 in spinal cord associated with gaba and spinal cord
11) Confidence 0.16 Published 1998 Journal Life Sci. Section Abstract Doc Link 9585130 Disease Relevance 0.40 Pain Relevance 0.82
If pCREB contributes to increased expression of NK1 receptors, pCREB should increase in neurons that express NK1 receptors under conditions that increase NK1 receptor mRNA.
Positive_regulation (increased) of Gene_expression (expression) of NK1 in neurons
12) Confidence 0.14 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10729626 Disease Relevance 0.07 Pain Relevance 0.12
SP: Substance P; DRG: dorsal root ganglion; NK-1: neurokinin-1; TRPV1: transient receptor potential vanilloid 1; TTX: tetrodotoxin; Sar-SP: [Sar9, Met(O2)11]-substance P; PKC: protein kinase C; BIM: bisindolylmaleimide; PKA: protein kinase A; PGE2: prostaglandin E2; PMA: phorbol 12-myristate 13-acetate; CFA: complete Freund's adjuvant.


Positive_regulation (-) of Gene_expression (tetrodotoxin) of NK-1 in dorsal root ganglion associated with ganglion cysts, tetrodotoxin, dorsal root ganglion, kinase c and substance p
13) Confidence 0.13 Published 2009 Journal Mol Pain Section Body Doc Link PMC2715383 Disease Relevance 0.27 Pain Relevance 0.70
SP: Substance P; DRG: dorsal root ganglion; NK-1: neurokinin-1; TRPV1: transient receptor potential vanilloid 1; TTX: tetrodotoxin; Sar-SP: [Sar9, Met(O2)11]-substance P; PKC: protein kinase C; BIM: bisindolylmaleimide; PKA: protein kinase A; PGE2: prostaglandin E2; PMA: phorbol 12-myristate 13-acetate; CFA: complete Freund's adjuvant.


Positive_regulation (-) of Gene_expression (adjuvant) of NK-1 in dorsal root ganglion associated with ganglion cysts, tetrodotoxin, dorsal root ganglion, kinase c and substance p
14) Confidence 0.13 Published 2009 Journal Mol Pain Section Body Doc Link PMC2715383 Disease Relevance 0.29 Pain Relevance 0.71
RSV induced overexpression of the neurokinin 1 (NK1) receptor for substance P on discrete lymphocyte subpopulations within the bronchial-associated lymphoid tissue (BALT), and treatment with a specific NK1 receptor antagonist abolished the recruitment of both lymphocytes and monocytes to infected airways.
Positive_regulation (induced) of in monocytes Gene_expression (overexpression) of NK1 in lymphocytes associated with antagonist, respiratory syncytial virus and substance p
15) Confidence 0.09 Published 2003 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 12639840 Disease Relevance 0.89 Pain Relevance 0.21
RSV induced overexpression of the neurokinin 1 (NK1) receptor for substance P on discrete lymphocyte subpopulations within the bronchial-associated lymphoid tissue (BALT), and treatment with a specific NK1 receptor antagonist abolished the recruitment of both lymphocytes and monocytes to infected airways.
Positive_regulation (overexpression) of in monocytes Gene_expression (overexpression) of NK1 in lymphocytes associated with antagonist, respiratory syncytial virus and substance p
16) Confidence 0.09 Published 2003 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 12639840 Disease Relevance 0.89 Pain Relevance 0.21
The enhanced expression of NK1 and BK receptors on sensory neurons might be an important mechanism by which arthritis causes pain and hyperalgesia.
Positive_regulation (enhanced) of Gene_expression (expression) of NK1 in sensory neurons associated with pain, hyperalgesia, bradykinin and arthritis
17) Confidence 0.06 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17819 Disease Relevance 1.59 Pain Relevance 1.51
SP-CTA was tested on Chinese Hamster Ovary cells that were stably transfected with the NK1 receptor [22] (CHO-NK1).
Positive_regulation (transfected) of Gene_expression (transfected) of NK1 in Ovary
18) Confidence 0.06 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1878491 Disease Relevance 0 Pain Relevance 0.34
Furthermore, these high levels of ERK activation were correlated with increased expression of the receptor NK1, NMDA subunits NR1, NR2A [115] and the transcription factor cAMP response element binding protein (CREB) [23].
Positive_regulation (increased) of Gene_expression (expression) of NK1
19) Confidence 0.04 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 1.18 Pain Relevance 0.33
The coincidence of the enhanced expression of NK1 and BK receptors on sensory neurons and the pain behaviour suggests that the upregulation of these receptors is relevant for the generation and maintenance of arthritic pain.
Positive_regulation (enhanced) of Gene_expression (expression) of NK1 in sensory neurons associated with pain, bradykinin and arthritis
20) Confidence 0.04 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17819 Disease Relevance 1.36 Pain Relevance 1.44

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