INT58599

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Context Info
Confidence 0.43
First Reported 1994
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.02
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Tacr3) plasma membrane (Tacr3) nucleus (Tacr3)
cytoplasm (Tacr3) signal transducer activity (Tacr3)
Anatomy Link Frequency
pancreas 1
dorsal root ganglia 1
Tacr3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 4 99.44 Very High Very High Very High
Dorsal horn 5 98.96 Very High Very High Very High
calcitonin gene related peptide 3 94.40 High High
substance P 15 93.68 High High
antagonist 2 90.24 High High
adenocard 1 88.24 High High
qutenza 1 84.24 Quite High
Antinociceptive 1 81.08 Quite High
Dorsal horn neuron 1 79.48 Quite High
Chronic pancreatitis 4 50.00 Quite Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 8 97.60 Very High Very High Very High
Nociception 4 95.64 Very High Very High Very High
Pancreatitis 4 75.84 Quite High
Pain 3 75.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following injection of either formalin or complete Freund's adjuvant (CFA) into one hindpaw, the levels of expression of NK-1 and NK-3 mRNAs in the spinal cord dorsal horn and preprotachykinin (PPT) mRNA expression in the lumbar dorsal root ganglia (DRG) were quantitated using solution hybridization-nuclease protection assays.
Transcription (expression) of NK-3 in dorsal root ganglia associated with dorsal horn and spinal cord
1) Confidence 0.43 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 8301359 Disease Relevance 0.33 Pain Relevance 0.68
Expression of mRNA for CGRP1 receptors, muscarinic m2, m3 and m5 receptors and neurokinin1 (NK1) and NK3, receptors was detected.
Transcription (Expression) of NK3
2) Confidence 0.03 Published 2000 Journal Auton Neurosci Section Abstract Doc Link 11593767 Disease Relevance 0.55 Pain Relevance 0.44
RESULTS: In CP tissues, NK-2R and PPT-A expression was increased, whereas NK-3R and NEP mRNA levels were comparable with normal pancreas.
Transcription (levels) of NK-3R in pancreas
3) Confidence 0.00 Published 2007 Journal Ann. Surg. Section Body Doc Link 17968170 Disease Relevance 0.15 Pain Relevance 0

General Comments

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