INT586

Context Info Confidence 0.64 First Reported 1975 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 1.69 Pain Relevance 0.28

cell proliferation (Lipa) cell morphogenesis (Lipa) lipid metabolic process (Lipa) lysosome (Lipa)

Anatomy Link Frequency nucleus 1 Lipa (Mus musculus)

Pain Link Frequency Relevance Heat trigeminal ganglion 3 92.08 Hsan 2 83.48 Bile 2 37.40 Inflammation 12 5.00 Central nervous system 8 5.00 tolerance 4 5.00 Enkephalin 2 5.00 Inflammatory response 2 5.00 metalloproteinase 2 5.00 Hippocampus 2 5.00

Disease Link Frequency Relevance Heat Ganglion Cysts 4 96.32 Atherosclerotic Plaque 10 91.36 Dystonia 2 83.88 Hereditary Sensory And Autonomic Neuropathies 2 83.48 Atherosclerosis 34 80.56 Disease 82 80.00 Frailty 1 73.04 Neurodegenerative Disease 2 50.48 Dementia 2 42.40 Toxicity 12 34.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Subsequent to this observation, numerous neurones showed central chromatolysis, eccentric nucleus and increased lysosomal hydrolase activity.

Positive_regulation (increased) of lysosomal hydrolase in nucleus

1) Confidence 0.64 Published 1975 Journal Acta Neuropathol. Section Abstract Doc Link 52273 Disease Relevance 0.82 Pain Relevance 0.28

It has been theorized that oxLDL could accentuate accumulation of CE through inactivation of lysosomal acid lipase (LAL).

Positive_regulation (inactivation) of LAL

2) Confidence 0.17 Published 2009 Journal Microb Cell Fact Section Body Doc Link PMC2674406 Disease Relevance 0.44 Pain Relevance 0

It has been theorized that oxLDL could accentuate accumulation of CE through inactivation of lysosomal acid lipase (LAL).

Positive_regulation (inactivation) of lysosomal acid lipase

3) Confidence 0.17 Published 2009 Journal Microb Cell Fact Section Body Doc Link PMC2674406 Disease Relevance 0.44 Pain Relevance 0

General Comments

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