INT58606

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Context Info
Confidence 0.20
First Reported 1994
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Prss12)
Anatomy Link Frequency
brain 4
neurons 2
Prss12 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 9 98.76 Very High Very High Very High
agonist 49 94.80 High High
Analgesic 22 76.32 Quite High
tail-flick 6 69.60 Quite High
Pain 47 50.00 Quite Low
intrathecal 9 28.40 Quite Low
Spinal cord 18 14.76 Low Low
isoflurane 1 7.52 Low Low
Inflammation 14 5.00 Very Low Very Low Very Low
Lasting pain 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 61 50.00 Quite Low
Nociception 45 5.00 Very Low Very Low Very Low
INFLAMMATION 15 5.00 Very Low Very Low Very Low
Ganglion Cysts 5 5.00 Very Low Very Low Very Low
Inflammatory Pain 4 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 3 5.00 Very Low Very Low Very Low
Low Back Pain 2 5.00 Very Low Very Low Very Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

2 5.00 Very Low Very Low Very Low
Neuropathic Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, when eight of these analogs were tested for their ability to inhibit [125I]NT binding and to potentiate K(+)-evoked DA release in primary cultures of rat mesencephalic neurons, it was found that they all behaved as agonists with binding and biological potencies quite similar to those observed in the other binding assays.
Negative_regulation (inhibit) of NT Binding (binding) of in neurons associated with dopamine and agonist
1) Confidence 0.20 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8301574 Disease Relevance 0 Pain Relevance 0.35
The results show that NT receptors in homogenates from newborn mouse and rat brain and from COS 7 cells transfected with the cloned high-affinity NT receptor from the adult rat brain displayed virtually identical structure-activity relationships toward a series of 12 peptide and pseudopeptide NT analogs, as assessed by the ability of the compounds to inhibit the binding of [125I]NT binding in these systems.
Negative_regulation (inhibit) of NT Binding (binding) of in brain
2) Confidence 0.20 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8301574 Disease Relevance 0 Pain Relevance 0.33
The results show that NT receptors in homogenates from newborn mouse and rat brain and from COS 7 cells transfected with the cloned high-affinity NT receptor from the adult rat brain displayed virtually identical structure-activity relationships toward a series of 12 peptide and pseudopeptide NT analogs, as assessed by the ability of the compounds to inhibit the binding of [125I]NT binding in these systems.
Negative_regulation (inhibit) of NT Binding (binding) of in brain
3) Confidence 0.20 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8301574 Disease Relevance 0 Pain Relevance 0.33
Specific binding was calculated as the difference between total binding (zero competing compound) and nonspecific binding (excess competing compound) and the IC50 values were determined from inhibition curves as the unlabeled ligand concentration inhibiting 50% of [3H]-NT-specific binding.
Negative_regulation (inhibiting) of NT Binding (binding) of
4) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2714839 Disease Relevance 0 Pain Relevance 0

General Comments

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