INT58606

Context Info Confidence 0.20 First Reported 1994 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 0 Pain Relevance 1.01

peptidase activity (Prss12)

Anatomy Link Frequency brain 4 neurons 2 Prss12 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Dopamine 9 98.76 agonist 49 94.80 Analgesic 22 76.32 tail-flick 6 69.60 Pain 47 50.00 intrathecal 9 28.40 Spinal cord 18 14.76 isoflurane 1 7.52 Inflammation 14 5.00 Lasting pain 11 5.00

Disease Link Frequency Relevance Heat Pain 61 50.00 Nociception 45 5.00 INFLAMMATION 15 5.00 Ganglion Cysts 5 5.00 Inflammatory Pain 4 5.00 Injury 4 5.00 Urological Neuroanatomy 3 5.00 Low Back Pain 2 5.00 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super / Visceral Pain 2 5.00 Neuropathic Pain 2 5.00

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Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, when eight of these analogs were tested for their ability to inhibit [125I]NT binding and to potentiate K(+)-evoked DA release in primary cultures of rat mesencephalic neurons, it was found that they all behaved as agonists with binding and biological potencies quite similar to those observed in the other binding assays.

Negative_regulation (inhibit) of NT Binding (binding) of in neurons associated with dopamine and agonist

1) Confidence 0.20 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8301574 Disease Relevance 0 Pain Relevance 0.35

The results show that NT receptors in homogenates from newborn mouse and rat brain and from COS 7 cells transfected with the cloned high-affinity NT receptor from the adult rat brain displayed virtually identical structure-activity relationships toward a series of 12 peptide and pseudopeptide NT analogs, as assessed by the ability of the compounds to inhibit the binding of [125I]NT binding in these systems.

Negative_regulation (inhibit) of NT Binding (binding) of in brain

2) Confidence 0.20 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8301574 Disease Relevance 0 Pain Relevance 0.33

The results show that NT receptors in homogenates from newborn mouse and rat brain and from COS 7 cells transfected with the cloned high-affinity NT receptor from the adult rat brain displayed virtually identical structure-activity relationships toward a series of 12 peptide and pseudopeptide NT analogs, as assessed by the ability of the compounds to inhibit the binding of [125I]NT binding in these systems.

Negative_regulation (inhibit) of NT Binding (binding) of in brain

3) Confidence 0.20 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8301574 Disease Relevance 0 Pain Relevance 0.33

Specific binding was calculated as the difference between total binding (zero competing compound) and nonspecific binding (excess competing compound) and the IC50 values were determined from inhibition curves as the unlabeled ligand concentration inhibiting 50% of [3H]-NT-specific binding.

Negative_regulation (inhibiting) of NT Binding (binding) of

4) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2714839 Disease Relevance 0 Pain Relevance 0

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