INT58607

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Context Info
Confidence 0.43
First Reported 1994
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 1.89
Pain Relevance 7.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Dll1) plasma membrane (Dll1) cell-cell signaling (Dll1)
Anatomy Link Frequency
brain 6
T-cell 1
Dll1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 21 99.98 Very High Very High Very High
opioid receptor 41 99.96 Very High Very High Very High
Opioid 7 99.52 Very High Very High Very High
antinociception 6 99.24 Very High Very High Very High
antagonist 13 98.64 Very High Very High Very High
Spinal cord 1 98.08 Very High Very High Very High
Enkephalin 43 97.40 Very High Very High Very High
Morphine 6 96.60 Very High Very High Very High
Physical dependence 3 93.88 High High
tail-flick 2 93.60 High High
Disease Link Frequency Relevance Heat
Embryonic Lethality 2 99.88 Very High Very High Very High
Hypoxia 12 99.36 Very High Very High Very High
Sprains And Strains 12 98.68 Very High Very High Very High
Urological Neuroanatomy 1 97.40 Very High Very High Very High
Drug Dependence 3 93.88 High High
Disease 12 92.48 High High
General Immunology 8 70.96 Quite High
Pressure And Volume Under Development 6 64.08 Quite High
Heart Rate Under Development 6 61.04 Quite High
Body Weight 32 59.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Loss-of-function of Dll1 leads to embryonic lethality, but reduction of Delta-like 1 protein levels has not been studied in adult stage.


Negative_regulation (reduction) of Delta-like 1 protein associated with embryonic lethality
1) Confidence 0.43 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2699037 Disease Relevance 0.39 Pain Relevance 0
The exchange of an amino acid in the 6th EGF-repeat of the Delta-like 1 protein (C413Y) leads to a phenotype that is, except for alterations in the B- and T-cell patterns, almost identical to the complete loss of an entire Dll1 allele.
Negative_regulation (loss) of Dll1 in T-cell
2) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0.06 Pain Relevance 0
In the former two brain regions, alpha1C and alpha1D subunits of L-type HVCCs and alpha2/delta1 subunit increased, although decreases of alpha1B and alpha2/delta1 subunits were observed in the cerebellum.
Negative_regulation (decreases) of delta1 in brain
3) Confidence 0.42 Published 2007 Journal J. Pharmacol. Sci. Section Abstract Doc Link 17917366 Disease Relevance 0.17 Pain Relevance 0.70
At high doses these ligands, including BNTX, exhibited decreased delta1 selectivity due to increases in the ED50 ratios of [D-Ser2,Leu5]enkephalin-Thr6 and morphine.
Negative_regulation (decreased) of delta1 associated with enkephalin and morphine
4) Confidence 0.31 Published 1998 Journal J. Med. Chem. Section Abstract Doc Link 9767654 Disease Relevance 0 Pain Relevance 0.49
The present data demonstrate a deficiency in delta1 and delta2 opioid antinociception in CXBK mice concomitant with reductions in whole-brain delta2 receptor binding and regional increases in DOR-1.
Negative_regulation (deficiency) of delta1 in brain associated with antinociception and opioid
5) Confidence 0.30 Published 1998 Journal Brain Res. Section Abstract Doc Link 9733948 Disease Relevance 0.42 Pain Relevance 1.07
The lowest effective 7-benzylidenenaltrexone dose was 3000-fold lower than the lowest effective naltrindole dose indicating that the acute adaptation to hypoxia was predominantly sensitive to delta-1 blockade.
Negative_regulation (blockade) of delta-1 associated with hypoxia
6) Confidence 0.29 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8301596 Disease Relevance 0.85 Pain Relevance 0.62
The results suggest that multiple injections of delta1- and delta2-opioid receptor agonists down-regulate delta1-opioid receptors of the brain by modifying Bmax and Kd values of [3H][D-Pen2,D-Pen5]enkephalin binding, respectively.
Negative_regulation (down-regulate) of delta1 in brain associated with agonist, enkephalin and opioid receptor
7) Confidence 0.27 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9369369 Disease Relevance 0 Pain Relevance 1.11
On the other hand, short term treatment of mice with delta2-opioid receptor agonist down-regulates brain delta1-opioid receptors by increasing Kd of the ligand which is partially reversed by concurrent treatment with LY 235959 but not by MK-801.
Negative_regulation (down-regulates) of delta1 in brain associated with agonist and opioid receptor
8) Confidence 0.27 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9369369 Disease Relevance 0 Pain Relevance 0.89
It is concluded that short term treatment of mice with delta1-opioid receptor agonist down-regulates brain delta1-opioid receptors by decreasing Bmax of the ligand which is partially reversed by concurrent treatment with MK-801 but not by LY 235959.
Negative_regulation (down-regulates) of delta1 in brain associated with agonist and opioid receptor
9) Confidence 0.27 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9369369 Disease Relevance 0 Pain Relevance 1.06
MK-801 and LY 235959 reverse delta1- and delta2-opioid receptor agonists-induced down-regulation of brain delta1-opioid receptor, respectively, apparently by different mechanisms.
Negative_regulation (down-regulation) of delta1 in brain associated with agonist and opioid receptor
10) Confidence 0.27 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9369369 Disease Relevance 0 Pain Relevance 1.12

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