INT5861

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Context Info
Confidence 0.78
First Reported 1990
Last Reported 2010
Negated 2
Speculated 10
Reported most in Abstract
Documents 203
Total Number 213
Disease Relevance 49.35
Pain Relevance 68.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr1) intracellular (Egr1) DNA binding (Egr1)
transcription factor binding (Egr1) cytoplasm (Egr1)
Anatomy Link Frequency
brain 10
neurons 10
dorsal horn 8
neuronal 8
hippocampus 7
Egr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 898 100.00 Very High Very High Very High
Inflammation 597 100.00 Very High Very High Very High
anesthesia 140 100.00 Very High Very High Very High
Nerve growth factor 17 100.00 Very High Very High Very High
Dorsal horn neuron 25 99.98 Very High Very High Very High
nMDA receptor 64 99.92 Very High Very High Very High
nMDA receptor antagonist 74 99.90 Very High Very High Very High
Dorsal horn 743 99.88 Very High Very High Very High
agonist 131 99.84 Very High Very High Very High
Glutamate receptor 54 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 1231 100.00 Very High Very High Very High
INFLAMMATION 587 100.00 Very High Very High Very High
Cancer 37 100.00 Very High Very High Very High
Stress 87 99.84 Very High Very High Very High
Lumbar Puncture Related Headaches 2 99.84 Very High Very High Very High
Cognitive Disorder 250 99.82 Very High Very High Very High
Anxiety Disorder 366 99.78 Very High Very High Very High
Nociception 139 99.78 Very High Very High Very High
Convulsion 12 99.72 Very High Very High Very High
Repression 63 99.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The KROX-24 protein, a new transcription regulating factor: expression in the rat central nervous system following afferent somatosensory stimulation.
Gene_expression (expression) of KROX-24 in central nervous system associated with central nervous system
1) Confidence 0.78 Published 1990 Journal Neurosci. Lett. Section Title Doc Link 2293086 Disease Relevance 0.08 Pain Relevance 0.51
Electrical stimulation of sciatic nerve A- and C-fibers, but not of A alpha- and A beta-fibers alone, induced transient expression of KROX-24 in numerous spinal neurons in the termination area of the stimulated nerve.
Gene_expression (expression) of KROX-24 in nerve associated with c fibre and sciatic nerve
2) Confidence 0.78 Published 1990 Journal Neurosci. Lett. Section Abstract Doc Link 2293086 Disease Relevance 0.09 Pain Relevance 0.64
Comparison of alterations in c-fos and Egr-1 (zif268) expression throughout the rat brain following acute administration of different classes of antidepressant compounds.
Gene_expression (expression) of Egr-1 in brain associated with antidepressant
3) Confidence 0.78 Published 2005 Journal Neuropsychopharmacology Section Title Doc Link 15812568 Disease Relevance 0 Pain Relevance 0.40
Although acute antidepressant administration altered c-fos expression in a number of brain regions, Egr-1 expression was only significantly altered in the central amygdala, suggesting that Egr-1 may not be as useful a marker to investigate acute antidepressant treatment.
Gene_expression (expression) of Egr-1 in amygdala associated with antidepressant and amygdala
4) Confidence 0.78 Published 2005 Journal Neuropsychopharmacology Section Abstract Doc Link 15812568 Disease Relevance 0 Pain Relevance 0.55
The serotonergic system modulates the cocaine-induced expression of the immediate early genes egr-1 and c-fos in rat brain.
Gene_expression (expression) of egr-1 in brain associated with cocaine
5) Confidence 0.78 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 9668660 Disease Relevance 0 Pain Relevance 0.38
Cocaine-induced egr-1 and c-fos expression was substantially reduced in the brain areas from rats in which the serotonergic projections were lesioned by injection of the neurotoxin 5,7-dihydroxytryptamine and in rats that have been injected with tropisetron, an antagonist of the 5-hydroxytryptamine (5-HT3) receptor.
Gene_expression (expression) of egr-1 in brain associated with antagonist and cocaine
6) Confidence 0.78 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9668660 Disease Relevance 0 Pain Relevance 0.44
Expression of c-fos, a member of the leucine zipper family, zif/268 (NGFI-A, egr1 and Krox-24), a member of the zinc finger family, and the opioid peptide, preprodynorphin, was investigated in various regions of rat forebrain with quantitative in situ hybridization histochemistry 1, 2, 3, 6 or 30 h after injection.
Spec (investigated) Gene_expression (Expression) of egr1 in forebrain associated with opioid
7) Confidence 0.76 Published 1995 Journal Neuroscience Section Abstract Doc Link 7477938 Disease Relevance 0.08 Pain Relevance 0.22
Expression of c-fos, a member of the leucine zipper family, zif/268 (NGFI-A, egr1 and Krox-24), a member of the zinc finger family, and the opioid peptide, preprodynorphin, was investigated in various regions of rat forebrain with quantitative in situ hybridization histochemistry 1, 2, 3, 6 or 30 h after injection.
Spec (investigated) Gene_expression (Expression) of Krox-24 in forebrain associated with opioid
8) Confidence 0.76 Published 1995 Journal Neuroscience Section Abstract Doc Link 7477938 Disease Relevance 0.08 Pain Relevance 0.22
The suppressive effects of pentobarbital were not specific to c-Fos, such that pentobarbital also suppressed expression of ITFs FosB and Egr1 in the striatum of cocaine-treated rats.
Gene_expression (expression) of Egr1 in striatum associated with cocaine
9) Confidence 0.75 Published 2000 Journal Brain Res. Section Abstract Doc Link 10986339 Disease Relevance 0.06 Pain Relevance 0.68
During the "central sensitization" phenomenon, noxious stimuli lead to expression of IEGs (c-fos, c-jun, krox-24); their proteic products have been postulated to convert short-term stimulations into long-lasting responses in dorsal-horn neurons.
Gene_expression (expression) of krox-24 in dorsal associated with central sensitization
10) Confidence 0.75 Published 1997 Journal Int J Clin Pharmacol Res Section Abstract Doc Link 9403355 Disease Relevance 0 Pain Relevance 0.37
The expression of fra-1, NGFI-C, egr-3 and Nurr1 did not show any change.
Gene_expression (expression) of NGFI
11) Confidence 0.75 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7808222 Disease Relevance 0.41 Pain Relevance 0.14
The expression of c-JUN, JUN B, FOS B and KROX-24 proteins paralleled that of c-FOS.
Gene_expression (expression) of KROX-24
12) Confidence 0.75 Published 1993 Journal Neuroscience Section Abstract Doc Link 8100045 Disease Relevance 0 Pain Relevance 0.67
The expressions of c-JUN, JUN B, c-FOS FOS B and KROX-24 proteins were investigated by immunocytochemistry following the application of formalin (5%, 50 microliters) into the plantar skin of one hindpaw.
Spec (investigated) Gene_expression (expressions) of KROX-24 in skin
13) Confidence 0.75 Published 1993 Journal Neuroscience Section Abstract Doc Link 8100045 Disease Relevance 0 Pain Relevance 0.24
The transcriptional profile of gene expression in PC12 cells indicated that ALC, in the presence of NGF, was able to positively modulate NGFI-A expression, a gene relevant in the rescue from tissue-specific toxicity.
Gene_expression (expression) of NGFI-A
14) Confidence 0.75 Published 2003 Journal Clin. Cancer Res. Section Body Doc Link 14654561 Disease Relevance 0.06 Pain Relevance 0
Intravenous injection of Kelatorphan (5, 10 and 20 mg/kg), an inhibitor of multiple enkephalin-degrading enzymes, 20 min before noxious stimulation reduced the overall number of dorsal horn neurons expressing c-FOS and NGF1-A by up to 20-30%.
Gene_expression (expressing) of NGF1 in dorsal horn associated with enkephalin and dorsal horn neuron
15) Confidence 0.75 Published 1994 Journal Pain Section Abstract Doc Link 8159434 Disease Relevance 0 Pain Relevance 0.77
In this study, we studied the effect of capsaicin-induced stress on the expression of the immediate-early genes (IEGs) NGFI-A, -B, -C, egr-2, -3 and Nurr1 in the rat adrenal gland using in situ hybridization.
Gene_expression (expression) of NGFI-A in adrenal gland associated with stress and qutenza
16) Confidence 0.75 Published 2000 Journal Brain Res. Section Abstract Doc Link 10986333 Disease Relevance 0.40 Pain Relevance 0.27
Expression of the immediate-early genes (IEG) c-FOS, NGF1-A and c-JUN was induced by noxious thermal stimulation in neurons of the rat spinal cord dorsal horn.
Gene_expression (Expression) of NGF1 in spinal cord dorsal horn associated with dorsal horn and spinal cord
17) Confidence 0.75 Published 1994 Journal Pain Section Abstract Doc Link 8159434 Disease Relevance 0 Pain Relevance 0.43
We confirmed the enriched expression of the following genes: a transcription factor NGFI-A, a putative four repeat ion channel, a vesicle associated calcium/calmodulin binding protein that is homologous to CAMK IV, a neuronal calcium sensor protein hippocalcin, synuclein beta, and an EST gene.
Gene_expression (expression) of NGFI-A in neuronal
18) Confidence 0.75 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC126259 Disease Relevance 0 Pain Relevance 0.31
NGFI-A, NGFI-B and Nurr1 expression persisted for 6 h.
Gene_expression (expression) of NGFI-A
19) Confidence 0.75 Published 2000 Journal Brain Res. Section Abstract Doc Link 10986333 Disease Relevance 0.48 Pain Relevance 0.36
Noradrenergic (NAergic) transmission in the rat cerebral cortex has recently been shown to be involved in the regulation of the basal expression of NGFI-A, an immediate early gene (IEG) which encodes a zinc-finger transcription factor.
Gene_expression (expression) of NGFI-A in cerebral cortex associated with cerebral cortex
20) Confidence 0.75 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7723621 Disease Relevance 0 Pain Relevance 0.18

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