INT5862

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Context Info
Confidence 0.70
First Reported 1990
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 82
Total Number 84
Disease Relevance 30.40
Pain Relevance 33.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr1) intracellular (Egr1) DNA binding (Egr1)
transcription factor binding (Egr1) cytoplasm (Egr1)
Anatomy Link Frequency
striatum 6
neurons 5
brain 3
amygdala 3
lamina 3
Egr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 16 100.00 Very High Very High Very High
cocaine 15 100.00 Very High Very High Very High
Nerve growth factor 6 100.00 Very High Very High Very High
Inflammation 277 99.98 Very High Very High Very High
medulla 39 99.84 Very High Very High Very High
cINOD 47 99.80 Very High Very High Very High
depression 26 99.80 Very High Very High Very High
withdrawal 19 99.80 Very High Very High Very High
agonist 50 99.78 Very High Very High Very High
tetrodotoxin 12 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 337 100.00 Very High Very High Very High
Nociception 62 100.00 Very High Very High Very High
INFLAMMATION 294 99.98 Very High Very High Very High
Injury 52 99.98 Very High Very High Very High
Depression 22 99.80 Very High Very High Very High
Apoptosis 57 99.52 Very High Very High Very High
Stress 45 99.40 Very High Very High Very High
Hypoxia 8 99.20 Very High Very High Very High
Shock 45 99.12 Very High Very High Very High
Colon Cancer 16 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In stimulated animals, the KROX-24-IR was induced in many areas including the lateral reticular nucleus, parabrachial nucleus, periaqueductal gray, hypothalamus, amygdala and lateral habenular nucleus.
Positive_regulation (induced) of KROX-24 in lateral reticular nucleus associated with amygdala, central grey and parabrachial
1) Confidence 0.70 Published 1990 Journal Neurosci. Lett. Section Abstract Doc Link 2293086 Disease Relevance 0.17 Pain Relevance 0.63
Using in situ hybridization, we found that acute cocaine administration (20 mg/kg, intraperitoneally (i.p.)) produced a robust induction of both c-fos and egr-1 immediate early genes.
Positive_regulation (induction) of egr-1 associated with cocaine
2) Confidence 0.70 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9668660 Disease Relevance 0 Pain Relevance 0.35
Egr-1 messenger RNA induction was highest in the caudate putamen and in the shell of the nucleus accumbens.
Positive_regulation (induction) of Egr-1 in caudate putamen associated with nucleus accumbens
3) Confidence 0.70 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9668660 Disease Relevance 0 Pain Relevance 0.37
Zif-268 mRNA levels increased in the lesioned dorsolateral striatum after either acute or subchronic L-DOPA administration.
Positive_regulation (increased) of Zif-268 mRNA in striatum
4) Confidence 0.69 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15813929 Disease Relevance 0 Pain Relevance 0.24
On the other hand, high induction of NGFI-A mRNA in the central amygdala was observed in RLA-I rats when they experienced amphetamine for the first time in the challenge.
Positive_regulation (induction) of NGFI-A in amygdala associated with amygdala
5) Confidence 0.67 Published 2008 Journal Neuroscience Section Abstract Doc Link 18093743 Disease Relevance 0.07 Pain Relevance 0.18
The time course of the induction of NGFI-A, NGFI-B, fra-2 and TIS11 was similar to that previously observed with c-fos and the members of the jun family.
Positive_regulation (induction) of NGFI-A
6) Confidence 0.67 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7808222 Disease Relevance 0.40 Pain Relevance 0.13
Administration of a high dose of caffeine (100 mg/kg) decreased locomotor behavior and increased NGFI-A and NGFI-B mRNA in the entire striatum.
Positive_regulation (increased) of NGFI-A in striatum
7) Confidence 0.67 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7472512 Disease Relevance 0 Pain Relevance 0.14
The large increases in c-fos and Egr1 for permethrin and not deltamethrin are consistent with the microarray data as these two genes were identified as dose-responsive at 6 h for the former and not the latter compound.
Positive_regulation (increases) of Egr1
8) Confidence 0.65 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0 Pain Relevance 0.04
Arc and zif268, two genes previously coupled to LTP of synaptic transmission in the adult brain, are upregulated at the same frequencies that give stable LTF (30 and 100 Hz).
Positive_regulation (upregulated) of zif268 in adult brain associated with aids-related complex
9) Confidence 0.65 Published 2008 Journal Neuroscience Section Abstract Doc Link 18555615 Disease Relevance 0.41 Pain Relevance 0.51
Based on the fact that long-term potentiation induction in the hippocampus during waking (WK) leads to zif-268 gene upregulation in the cortex during subsequent REM sleep (Ribeiro et al., 2002), that such upregulation requires concomitant hippocampal activity (Ribeiro et al., 2002), and that it progresses over time in an anterograde manner across specific cortical areas (Ribeiro et al., 2002), we proposed that REM sleep is a privileged window for the propagation of memory traces from the hippocampus to the cerebral cortex (Pavlides and Ribeiro, 2003; Ribeiro and Nicolelis, 2004; Ribeiro et al., 2002).
Positive_regulation (upregulation) of zif-268 in hippocampus associated with hippocampus, long-term potentiation and cerebral cortex
10) Confidence 0.64 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.09 Pain Relevance 0.18
Activation of MAPK cascade might be mediated by neurotensin receptor via Egr1, which is known to be upregulated in response to persistent inflammatory pain [29] and stimulates Erk1/2 phosphorylation [36].
Positive_regulation (upregulated) of Egr1 associated with eae
11) Confidence 0.61 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2315656 Disease Relevance 1.00 Pain Relevance 1.00
shown histochemically by the upregulation of Arc, Zif268, and to a lesser
Positive_regulation (upregulation) of Zif268 associated with aids-related complex
12) Confidence 0.59 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.84 Pain Relevance 0
Induction of c-Fos and zif268 in the nociceptive amygdala parallel abstinence hyperalgesia in rats briefly exposed to morphine.
Positive_regulation (Induction) of zif268 in amygdala associated with nociception, hyperalgesia, narcan, amygdala and morphine
13) Confidence 0.56 Published 2007 Journal Neuropharmacology Section Title Doc Link 17631915 Disease Relevance 0.63 Pain Relevance 1.53
To the extent that persistent changes in firing rates indicate mnemonic processing (Fuster and Jervey, 1981), and that arc and zif-268 transcriptional upregulation correlates with synaptic remodeling (Guzowski et al., 2000; Jones et al., 2001), our data support the notion that memories produced by novel stimulation during WK are reactivated during SWS and stored during REM sleep, in a two-step consolidation process (Ribeiro and Nicolelis, 2004) otherwise similar to one-step memory reconsolidation (Nader, 2003; Stickgold and Walker, 2005).
Positive_regulation (upregulation) of zif-268 associated with aids-related complex
14) Confidence 0.56 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.22 Pain Relevance 0.09
whereas Zif268 was elevated equally in both DG blades.
Positive_regulation (elevated) of Zif268
15) Confidence 0.51 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.85 Pain Relevance 0
Cocaine-induced egr-1 and c-fos expression was substantially reduced in the brain areas from rats in which the serotonergic projections were lesioned by injection of the neurotoxin 5,7-dihydroxytryptamine and in rats that have been injected with tropisetron, an antagonist of the 5-hydroxytryptamine (5-HT3) receptor.
Positive_regulation (Cocaine-induced) of egr-1 in brain associated with antagonist and cocaine
16) Confidence 0.50 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9668660 Disease Relevance 0 Pain Relevance 0.44
We now report that, like zif268, krox-20 is rapidly and transiently activated by electroconvulsive shock treatment (ECT), D1 dopamine receptor activation, and opiate withdrawal.
Positive_regulation (activated) of zif268 associated with dopamine receptor, shock, opiate and withdrawal
17) Confidence 0.49 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1317498 Disease Relevance 0.10 Pain Relevance 0.19
The decrease of mRNA for NGFI-A, NGFI-B, and jun B caused by caffeine (25 mg/kg) could be mimicked by the D2 agonist quinpirole (1 and 3 mg/kg).
Positive_regulation (caused) of NGFI-A associated with agonist
18) Confidence 0.49 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7472512 Disease Relevance 0 Pain Relevance 0.38
Prazosin reduced FCL(SD)-induced elevations of c-jun and c-fos, but not NGFI-A, mRNA.
Positive_regulation (elevations) of NGFI-A associated with depression
19) Confidence 0.49 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11072104 Disease Relevance 0.61 Pain Relevance 0.67
NGFI-A was induced in medulla within 15 min after stress, NGFI-B, egr-3 and Nurr1 were induced by 30 min, whereas NGFI-C was induced by 2 h.
Positive_regulation (induced) of NGFI-A in medulla associated with stress and medulla
20) Confidence 0.49 Published 2000 Journal Brain Res. Section Abstract Doc Link 10986333 Disease Relevance 0.47 Pain Relevance 0.34

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