INT58622

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Context Info
Confidence 0.75
First Reported 1994
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 15
Disease Relevance 2.86
Pain Relevance 4.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR7) signal transducer activity (HTR7)
Anatomy Link Frequency
saphenous vein 1
colon 1
brain 1
internal 1
small intestine 1
HTR7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 38 99.48 Very High Very High Very High
Sumatriptan 11 98.88 Very High Very High Very High
agonist 124 98.58 Very High Very High Very High
cerebral cortex 4 98.08 Very High Very High Very High
trigeminal ganglion 2 97.40 Very High Very High Very High
antagonist 56 96.28 Very High Very High Very High
Migraine 32 96.00 Very High Very High Very High
Neurotransmitter 2 95.64 Very High Very High Very High
Central nervous system 2 94.12 High High
fifth nerve 1 90.36 High High
Disease Link Frequency Relevance Heat
Cluster Headache 11 99.88 Very High Very High Very High
Ganglion Cysts 2 96.96 Very High Very High Very High
Increased Venous Pressure Under Development 2 96.28 Very High Very High Very High
Migraine Disorders 29 96.00 Very High Very High Very High
Vibrio Infection 2 92.16 High High
Vomiting 5 85.76 High High
Hyperalgesia 3 84.40 Quite High
Functional Bowel Disorder 16 83.76 Quite High
Pain 6 83.36 Quite High
Neurogenic Inflammation 3 82.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The 5-hydroxytryptamine 3 (5-HT3) receptor is expressed widely in the central and peripheral nervous systems, where it mediates or modulates a wide range of physiological processes.
Gene_expression (expressed) of 5-hydroxytryptamine in peripheral nervous systems
1) Confidence 0.75 Published 2008 Journal Trends Pharmacol. Sci. Section Abstract Doc Link 18597859 Disease Relevance 0.25 Pain Relevance 0.08
Endothelial expression of the 5-hydroxytryptamine1B antimigraine drug receptor in rat and human brain microvessels.
Gene_expression (expression) of 5-hydroxytryptamine in brain associated with cluster headache
2) Confidence 0.75 Published 1998 Journal Neuroscience Section Title Doc Link 9697110 Disease Relevance 0.27 Pain Relevance 0.17
Clonal cell lines stably expressing h5-HT7 receptor isoforms will serve as valuable cellular models to study their function and regulation, as well as assist in the development of selective 5-HT7 receptor agents to uncover the biological roles and potential therapeutic applications of this novel receptor subtype.
Gene_expression (expressing) of 5-HT7
3) Confidence 0.75 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9808674 Disease Relevance 0.09 Pain Relevance 0.18
Expression levels of the h5-HT7(a) receptor determined from saturation studies using either a labeled agonist ([3H]5-HT) or antagonist ([3H]LSD) were very similar (Bmax = 160-190 fmol/mg protein), suggesting that all receptors may exist in the high affinity (G protein-coupled) state.
Gene_expression (Expression) of 5-HT7 associated with antagonist and agonist
4) Confidence 0.75 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9808674 Disease Relevance 0 Pain Relevance 0.13
The present study investigated, by using the method of reverse transcriptase polymerase chain reaction, whether the 5-HT7 receptor mRNA is expressed in human trigeminal ganglia.
Gene_expression (expressed) of 5-HT7 in trigeminal ganglia
5) Confidence 0.65 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11278099 Disease Relevance 0 Pain Relevance 0.12
RT-PCR products corresponding to the human 5-HT2A, 5-HT1B and 5-HT1F receptors were expressed in high levels, mRNAs coding for 5-HT7, 5-HT1A and 5-HT1D receptors were only weakly expressed.
Gene_expression (expressed) of 5-HT7
6) Confidence 0.65 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10374714 Disease Relevance 0.07 Pain Relevance 0.26
The expression of 5-HT7 receptor mRNA was observed in porcine central (cerebral cortex, trigeminal ganglion and cerebellum) as well as in peripheral (pulmonary and coronary arteries, superior vena cava and saphenous vein) tissues.
Gene_expression (expression) of 5-HT7 in superior vena cava associated with ganglion cysts, trigeminal ganglion and cerebral cortex
7) Confidence 0.65 Published 2002 Journal Mol. Cell. Biochem. Section Abstract Doc Link 12349912 Disease Relevance 0.18 Pain Relevance 0.37
In agreement with the decreased binding affinity of 5-HT, 5-CT, RU24969 and 8-OH-DPAT for the variant receptor, these agonists were less potent in stimulating [3H]cAMP accumulation in cells stably expressing the Thr92Lys h5-HT7(a) receptor.
Gene_expression (expressing) of 5-HT7 associated with agonist
8) Confidence 0.58 Published 2005 Journal Neurochem. Int. Section Abstract Doc Link 15896881 Disease Relevance 0 Pain Relevance 0.40
The cloning and expression of an OK cell cDNA encoding a 5-hydroxytryptamine1B receptor.
Gene_expression (expression) of 5-hydroxytryptamine
9) Confidence 0.58 Published 1994 Journal Mol. Pharmacol. Section Title Doc Link 8302276 Disease Relevance 0 Pain Relevance 0.29
Isolated microvessels and capillaries consistently expressed messages for the h5-HT1B, h5-HT1D, 5-HT1F, 5-HT2A but not 5-HT7 receptors.
Gene_expression (expressed) of 5-HT7
10) Confidence 0.58 Published 1999 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 10458598 Disease Relevance 0 Pain Relevance 0.05
All tissues expressed 5-HT1Dbeta, 5-HT2A, 5-HT2B, 5-HT4 and 5-HT7 mRNAs.
Gene_expression (expressed) of 5-HT7
11) Confidence 0.29 Published 1996 Journal Eur. J. Neurosci. Section Abstract Doc Link 8743744 Disease Relevance 0.44 Pain Relevance 0.94
The expression of 5-HT7 receptor mRNA was observed in porcine central (cerebral cortex, trigeminal ganglion and cerebellum) as well as in peripheral (pulmonary and coronary arteries, superior vena cava and saphenous vein) tissues.
Gene_expression (expression) of 5-HT7 in saphenous vein associated with ganglion cysts, trigeminal ganglion and cerebral cortex
12) Confidence 0.22 Published 2002 Journal Mol. Cell. Biochem. Section Abstract Doc Link 12349912 Disease Relevance 0.18 Pain Relevance 0.37
All 5–HT7 receptor splice variants are expressed in the human small intestine and colon including a certain amount of the h5–HT7(d+5) fragment [43].
Gene_expression (expressed) of HT7 receptor in small intestine
13) Confidence 0.15 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0.31 Pain Relevance 0.28
The transcript of the 5–HT7 receptor has been detected in human internal carotid and menigeal arteries, but functional evidence for its potential role in migraine is lacking.
Gene_expression (detected) of HT7 receptor in internal associated with migraine
14) Confidence 0.13 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0.63 Pain Relevance 0.79
All 5–HT7 receptor splice variants are expressed in the human small intestine and colon including a certain amount of the h5–HT7(d+5) fragment [43].
Gene_expression (expressed) of HT7 receptor in colon
15) Confidence 0.05 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0.31 Pain Relevance 0.28

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