INT5864

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Context Info
Confidence 0.44
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 19
Total Number 19
Disease Relevance 14.50
Pain Relevance 6.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL36RN) extracellular region (IL36RN)
Anatomy Link Frequency
macrophages 4
monocytes 2
lymphocytes 1
lung 1
mononuclear cells 1
IL36RN (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 77 100.00 Very High Very High Very High
cytokine 44 100.00 Very High Very High Very High
Inflammatory mediators 7 100.00 Very High Very High Very High
antagonist 6 100.00 Very High Very High Very High
Catecholamine 1 100.00 Very High Very High Very High
Opioid 7 99.80 Very High Very High Very High
Enkephalin 5 99.66 Very High Very High Very High
narcan 2 99.66 Very High Very High Very High
corticosteroid 25 99.56 Very High Very High Very High
cINOD 17 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 104 100.00 Very High Very High Very High
Gauchers Disease 68 100.00 Very High Very High Very High
Stress 28 100.00 Very High Very High Very High
Cancer 17 100.00 Very High Very High Very High
Necrosis 14 100.00 Very High Very High Very High
Osteoarthritis 4 99.60 Very High Very High Very High
Sarcoidosis 73 99.52 Very High Very High Very High
Thrombophilia 2 99.52 Very High Very High Very High
Infection 82 99.48 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 86 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purpose of this study was to support the hypothesis that cytokines such as interleukin-1, tumor necrosis factor and interleukin-6 are released by macrophages or monocytes within 1 to 2 hr of phagocytosis of circulating, gut-derived bacterial lipopolysaccharide translocated by acute liver injury.
Localization (released) of interleukin-1 in macrophages associated with necrosis, cancer, injury and cytokine
1) Confidence 0.44 Published 1990 Journal Hepatology Section Abstract Doc Link 2114349 Disease Relevance 0.52 Pain Relevance 0.20
The findings are also consistent with regulation of interleukin-1 release which is independent of adrenal stimulation, cyclic AMP or beta-endorphin, as epidural analgesia prevents postoperative increase of these hormones.
Localization (release) of interleukin-1 associated with epidural and analgesia
2) Confidence 0.33 Published 1985 Journal Acta Chir Scand Section Abstract Doc Link 3872548 Disease Relevance 0.66 Pain Relevance 0.52
The drugs were unable to abrogate Interleukin 1 and Tumor Necrosis Factor alpha release by activated mononuclear cells.
Localization (release) of Interleukin 1 in mononuclear cells associated with necrosis and cancer
3) Confidence 0.32 Published 1994 Journal In Vitro Cell. Dev. Biol. Anim. Section Abstract Doc Link 7881628 Disease Relevance 0.68 Pain Relevance 0.34
In vitro effects of NSAIDs and corticosteroids on the synthesis and secretion of interleukin 1 by human osteoarthritic synovial membranes.
Localization (secretion) of interleukin 1 associated with corticosteroid, cinod and osteoarthritis
4) Confidence 0.26 Published 1993 Journal Agents Actions Suppl. Section Title Doc Link 8456629 Disease Relevance 0.46 Pain Relevance 0.62
Inhibition of the activity or release of various tissue damaging agents and inflammatory cytokines, e.g., thromboxane and interleukin 1, are described, as are in vivo animal studies that have revealed synergistic or potentiating analgesic and antiinflammatory activities between misoprostol and NSAID, particularly diclofenac.
Localization (release) of interleukin 1 associated with inflammation, analgesic, cinod, diclofenac and cytokine
5) Confidence 0.24 Published 1998 Journal J Rheumatol Suppl Section Abstract Doc Link 9596552 Disease Relevance 0.53 Pain Relevance 1.29
Stress, via the release of corticotropin-releasing factor (CRF), eventually triggered by interleukin 1, inhibits GnRH release, resulting in hypogonadism.
Localization (triggered) of interleukin 1 associated with reprotox - general 2 and stress
6) Confidence 0.18 Published 1993 Journal Environ Health Perspect Section Abstract Doc Link PMC1519927 Disease Relevance 1.11 Pain Relevance 0.18
The regulation of this increase in colonic temperature appears to be opioid in nature and not because of the release of the cytokine interleukin-1.
Localization (release) of interleukin-1 associated with opioid and cytokine
7) Confidence 0.17 Published 1992 Journal Physiol. Behav. Section Abstract Doc Link 1317589 Disease Relevance 0.33 Pain Relevance 0.30
When these crystals are deposited in synovial tissues, NLR proteins (NOD-like receptors) form multiprotein complexes known as inflammasomes that trigger secretion of inflammation-producing cytokines like interleukin-1?
Localization (secretion) of interleukin-1 associated with inflammation and cytokine
8) Confidence 0.16 Published 2010 Journal Metab. Clin. Exp. Section Abstract Doc Link 20837191 Disease Relevance 1.50 Pain Relevance 0.33
It has also been reported to reduce the secretion of interleukin-1 by activated lymphocytes in a similar dose-dependent fashion [32], and is a direct inhibitor of T-cell proliferation [33].
Localization (secretion) of interleukin-1 in lymphocytes
9) Confidence 0.08 Published 2007 Journal Placenta Section Body Doc Link PMC1878510 Disease Relevance 0.06 Pain Relevance 0
Lipopolysaccharide is one of the most potent trigger substances for monocytes and macrophages causing secretion of inflammatory mediators such as tumor necrosis factor and interleukin-1.
Localization (secretion) of interleukin-1 in macrophages associated with necrosis, inflammatory mediators and cancer
10) Confidence 0.06 Published 1996 Journal Oral Microbiol. Immunol. Section Abstract Doc Link 9467376 Disease Relevance 0.52 Pain Relevance 0.24
The elevated levels of CRP observed may be due to the release of pro-inflammatory cytokines such as interleukin-1 and -6 (IL-1, IL-6) from the activated cells in response to surgery and inflammation [21], [25].
Localization (release) of interleukin-1 associated with inflammation and cytokine
11) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.45 Pain Relevance 0.28
In vitro studies of human placental cells have shown CRH is released from cultured human placental cells in a dose-response manner to all major biological effectors of stress, including cortisol, catecholamines, oxytocin, angiotension II, and interleukin-1.
Localization (released) of interleukin-1 associated with stress and catecholamine
12) Confidence 0.04 Published 2010 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC2841774 Disease Relevance 1.60 Pain Relevance 0.22
In the plasma of patients with GD, the levels of macrophage/monocyte activation markers such as soluble CD14 and CD 163 are elevated.82 Gaucher cells strongly express markers of alternative activation, such as interleukin-1 antagonist and CCL18, which are anti-inflammatory molecules.83 Other biochemical correlates of GD represent hydrolases, localized to storage cells and/or surrounding macrophages, such as tartrate-resistant acid phosphatase and angiotensin-converting enzyme.84,85 These biomarkers, however, are nonspecific, and are altered in a number of disorders that affect the reticuloendothelial system.
Localization (localized) of interleukin-1 in macrophages associated with inflammation, antagonist and gauchers disease
13) Confidence 0.03 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2909498 Disease Relevance 0.88 Pain Relevance 0.13
and interleukin-1 are released by alveolar macrophages in patients with active lung disease.
Localization (released) of interleukin-1 in lung associated with pulmonary disease
14) Confidence 0.03 Published 2008 Journal Therapeutics and Clinical Risk Management Section Abstract Doc Link PMC2643111 Disease Relevance 1.17 Pain Relevance 0.33
Up-regulation of cytokines, primarily interleukin-1, and endotoxin release are implicated as causes for NO presence as both are found in increased amounts after burn and inhalation injury.
Localization (release) of interleukin-1 associated with burns, injury and cytokine
15) Confidence 0.02 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761179 Disease Relevance 0.92 Pain Relevance 0.13
Lipopolysaccharide is one of the most potent trigger substances for monocytes and macrophages causing secretion of inflammatory mediators such as tumor necrosis factor and interleukin-1.
Localization (secretion) of interleukin-1 in monocytes associated with necrosis, inflammatory mediators and cancer
16) Confidence 0.02 Published 1996 Journal Oral Microbiol. Immunol. Section Abstract Doc Link 9467376 Disease Relevance 0.52 Pain Relevance 0.24
In advanced HIV infection, excessive inappropriate elaboration of TNF alpha and interleukin-1 add to the thrombophilia.[10]
Localization (elaboration) of interleukin-1 associated with thrombophilia, acquired immune deficiency syndrome or hiv infection and infection
17) Confidence 0.01 Published 2005 Journal J Int AIDS Soc Section Body Doc Link PMC2740789 Disease Relevance 1.98 Pain Relevance 0.21
This may be due to less stimulation of monocytes resulting from the absence of bacteria, endotoxins and pyrogens in the dialysate, which would reduce the stimulation of cytokines release, interleukin 1 and 6, and tumor necrosis factor, known to stimulate beta 2 microglobulin synthesis.
Localization (release) of interleukin 1 in monocytes associated with necrosis, cancer and cytokine
18) Confidence 0.01 Published 1991 Journal Int J Artif Organs Section Abstract Doc Link 1757154 Disease Relevance 0.60 Pain Relevance 0.45
Opioids modulate interleukin-1 production and secretion by bone-marrow macrophages.
Localization (secretion) of interleukin-1 in macrophages associated with opioid
19) Confidence 0.01 Published 1990 Journal Immunol. Lett. Section Title Doc Link 2162329 Disease Relevance 0 Pain Relevance 0.86

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