INT58643

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Context Info
Confidence 0.50
First Reported 1994
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 6.59
Pain Relevance 3.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 1
external 1
skin 1
HMI (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 20 100.00 Very High Very High Very High
acular 24 98.38 Very High Very High Very High
Potency 5 96.64 Very High Very High Very High
Bioavailability 5 95.04 Very High Very High Very High
corticosteroid 34 93.08 High High
Inflammation 26 91.32 High High
Analgesic 6 86.24 High High
transdermal 8 83.52 Quite High
tetrodotoxin 45 81.44 Quite High
cva 29 80.32 Quite High
Disease Link Frequency Relevance Heat
Invasive Pulmonary Aspergillosis 211 100.00 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 76 100.00 Very High Very High Very High
Aggression 14 97.56 Very High Very High Very High
Hemorrhage 46 97.20 Very High Very High Very High
Cadaver 4 96.44 Very High Very High Very High
Acute Coronary Syndrome 38 96.28 Very High Very High Very High
Death 13 95.36 Very High Very High Very High
Adhesions 4 93.32 High High
INFLAMMATION 27 91.32 High High
Cancer 12 86.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the presence of DNP, glibenclamide (5 microM) not only inhibited IKATP but also partially restored Ito.
Spec (partially) Positive_regulation (restored) of Ito
1) Confidence 0.50 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 8304498 Disease Relevance 0 Pain Relevance 0.08
The solubility of ketorolac acid in an IPA/water binary vehicle mixture increased as the volume fraction of IPA increased from 0 to 90%.
Positive_regulation (increased) of IPA associated with acular and alcohol
2) Confidence 0.40 Published 1995 Journal J Pharm Sci Section Abstract Doc Link 8801333 Disease Relevance 0.08 Pain Relevance 1.14
The skin flux increased as the IPA volume fraction was increased from 0 to 50% and then leveled off beyond 80% IPA loading.
Positive_regulation (increased) of IPA in skin associated with alcohol
3) Confidence 0.40 Published 1995 Journal J Pharm Sci Section Abstract Doc Link 8801333 Disease Relevance 0.15 Pain Relevance 1.26
The V0.5s of activation and availability of Ito were 11.2±0.4 mV (n?
Positive_regulation (activation) of Ito
4) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0 Pain Relevance 0
In our case, L-AmB which was increased to the dose of 3 mg/kg/d when the GM test became positive was found to be effective for IPA due to A. flavus.
Positive_regulation (effective) of IPA associated with invasive pulmonary aspergillosis
5) Confidence 0.28 Published 2006 Journal Ann Clin Microbiol Antimicrob Section Body Doc Link PMC1550418 Disease Relevance 0.98 Pain Relevance 0
Our findings suggest that a larger Ito1 in the presence of normal external Na+ is due to 1) transient loss of voltage control and concomitant changes in activation of Ito1 and/or 2) facilitation of an outward current by intracellular Na+.
Positive_regulation (activation) of Ito1 in external
6) Confidence 0.22 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9038916 Disease Relevance 0 Pain Relevance 0.19
Health consequences of IPA
Positive_regulation (consequences) of IPA
7) Confidence 0.17 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2823699 Disease Relevance 0.83 Pain Relevance 0.13
Another mechanism is to reverse this process by deacetylating the hyper-acetylated histones through the recruitment of HDAC-2 to the activated co-activator complex (Ito et al., 2006).
Positive_regulation (activated) of Ito
8) Confidence 0.16 Published 2008 Journal Interdisciplinary Toxicology Section Body Doc Link PMC2993477 Disease Relevance 1.08 Pain Relevance 0.33
Among these patients, 2 had proven IPA, 3 had probable IPA, and 254 patients did not have IPA; the remaining 2 patients had possible IPA.
Spec (probable) Positive_regulation (had) of IPA associated with invasive pulmonary aspergillosis
9) Confidence 0.09 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2886868 Disease Relevance 1.37 Pain Relevance 0.12
Invasive pulmonary aspergillosis (IPA) among patients with chronic obstructive pulmonary disease (COPD) is increasing in frequency.
Positive_regulation (increasing) of IPA associated with chronic obstructive pulmonary disease and invasive pulmonary aspergillosis
10) Confidence 0.09 Published 2010 Journal Annals of Saudi Medicine Section Abstract Doc Link PMC2886868 Disease Relevance 1.14 Pain Relevance 0
One hour after administration of 300 mg/kg L-tryptophan to 1 month old male Sprague-Dawley rats, we observed that IPAM, melatonin and indole-3-propionic acid concentrations could be reproducibly measured as shown in Figure 1 at increased levels of 346±9 (IPAM), 713±32 (MEL) and 281±14 (IPA) pg indole/mg protein in rat brain (n?
Positive_regulation (increased) of IPA in brain
11) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858081 Disease Relevance 0 Pain Relevance 0.05
Although touting increased IPA, it should be recalled that traditionally this has been a measure of bleeding, not potency.
Positive_regulation (increased) of IPA associated with hemorrhage and potency
12) Confidence 0.01 Published 2009 Journal Western Journal of Emergency Medicine Section Body Doc Link PMC2729217 Disease Relevance 0.95 Pain Relevance 0.19

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