INT5865

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Context Info
Confidence 0.69
First Reported 1980
Last Reported 2010
Negated 14
Speculated 22
Reported most in Abstract
Documents 282
Total Number 304
Disease Relevance 84.86
Pain Relevance 93.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh) signal transduction (Gh) mitochondrion (Gh)
extracellular space (Gh) extracellular region (Gh) plasma membrane (Gh)
Anatomy Link Frequency
pituitary 58
plasma 25
body 16
thyroid 14
brain 10
Gh (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 606 100.00 Very High Very High Very High
antagonist 328 100.00 Very High Very High Very High
narcan 163 100.00 Very High Very High Very High
opiate 65 100.00 Very High Very High Very High
dexamethasone 30 100.00 Very High Very High Very High
agonist 326 99.98 Very High Very High Very High
Sumatriptan 251 99.98 Very High Very High Very High
Opioid 62 99.98 Very High Very High Very High
Morphine 40 99.98 Very High Very High Very High
dopamine receptor 11 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acromegaly 464 100.00 Very High Very High Very High
Diabetes Mellitus 124 100.00 Very High Very High Very High
Pituitary Cancer 85 100.00 Very High Very High Very High
Growth Problems 83 100.00 Very High Very High Very High
Hyperinsulinism 34 100.00 Very High Very High Very High
Sickle Cell Anemia 18 100.00 Very High Very High Very High
Gigantism 5 100.00 Very High Very High Very High
Hypoglycemia 55 99.98 Very High Very High Very High
Stress 40 99.98 Very High Very High Very High
Neurodegenerative Disease 3 99.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The level of GH secretion induced by clonidine was significantly reduced after ECT, but the hypotensive responses to clonidine remained unchanged.
Positive_regulation (induced) of Localization (secretion) of GH associated with hypotension and clonidine
1) Confidence 0.69 Published 1992 Journal Psychiatry Res Section Abstract Doc Link 1317592 Disease Relevance 0.19 Pain Relevance 0.29
This response is known to be blunted in depression, and neurochemical changes observed in senile dementia of the Alzheimer type (SDAT) could lead to an up-regulation of GH secretion.
Positive_regulation (lead) of Localization (secretion) of GH associated with dementia and depression
2) Confidence 0.69 Published 1989 Journal Psychiatry Res Section Abstract Doc Link 2710869 Disease Relevance 0.54 Pain Relevance 0.26
Clonidine-induced growth hormone secretion in elderly patients with senile dementia of the Alzheimer type and major depressive disorder.
Positive_regulation (induced) of Localization (secretion) of growth hormone associated with depression, dementia and clonidine
3) Confidence 0.69 Published 1989 Journal Psychiatry Res Section Title Doc Link 2710869 Disease Relevance 0.55 Pain Relevance 0.28
CONCLUSIONS: Clinical recovery was associated with an increase in GH release in response to dexamethasone.


Positive_regulation (increase) of Localization (release) of GH
4) Confidence 0.69 Published 1995 Journal Am J Psychiatry Section Body Doc Link 7694914 Disease Relevance 0 Pain Relevance 0
We conclude that higher doses (15 mg) of morphine are required to stimulate GH secretion in normal subjects, and that opioids exert a positive modulating effect on growth hormone secretion in patients with active acromegaly suggesting partial autonomy of the pituitary tumor.
Positive_regulation (stimulate) of Localization (secretion) of GH in pituitary associated with acromegaly, pituitary cancer, opioid and morphine
5) Confidence 0.68 Published 2005 Journal Horm. Metab. Res. Section Abstract Doc Link 16034714 Disease Relevance 0.57 Pain Relevance 0.65
We conclude that higher doses (15 mg) of morphine are required to stimulate GH secretion in normal subjects, and that opioids exert a positive modulating effect on growth hormone secretion in patients with active acromegaly suggesting partial autonomy of the pituitary tumor.
Positive_regulation (exert) of Localization (secretion) of growth hormone in pituitary associated with acromegaly, pituitary cancer, opioid and morphine
6) Confidence 0.68 Published 2005 Journal Horm. Metab. Res. Section Abstract Doc Link 16034714 Disease Relevance 0.57 Pain Relevance 0.64
Morphine at doses of 5 mg and 10 mg does not stimulate growth hormone (GH) secretion in normal subjects, and its effect on GH secretion in acromegaly is not widely documented.
Neg (not) Positive_regulation (stimulate) of Localization (secretion) of growth hormone associated with acromegaly and morphine
7) Confidence 0.68 Published 2005 Journal Horm. Metab. Res. Section Abstract Doc Link 16034714 Disease Relevance 0.32 Pain Relevance 0.38
Failure of the gamma-aminobutyric acid (GABA) derivative, baclofen, to stimulate growth hormone secretion in heroin addicts.
Positive_regulation (stimulate) of Localization (secretion) of growth hormone associated with gaba
8) Confidence 0.67 Published 1992 Journal Life Sci. Section Title Doc Link 1625515 Disease Relevance 0.24 Pain Relevance 0.31
We tested the hypothesis that differences in body composition and physical fitness rather than age determine stimulated GH secretion in healthy adults.
Spec (determine) Positive_regulation (stimulated) of Localization (secretion) of GH in body
9) Confidence 0.67 Published 1996 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8964853 Disease Relevance 0.51 Pain Relevance 0.19
In all equations abdominal adiposity and physical fitness, rather than age, contributed significantly to predict changes in arginine stimulated GH secretion.
Positive_regulation (stimulated) of Localization (secretion) of GH
10) Confidence 0.67 Published 1996 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8964853 Disease Relevance 0.24 Pain Relevance 0.39
Sleep, exercise, and intravenous infusion of 0.5 g/kg body weight of arginine stimulates GH secretion.
Positive_regulation (stimulates) of Localization (secretion) of GH in body associated with body weight
11) Confidence 0.66 Published 1991 Journal Indian J Pediatr Section Abstract Doc Link 1824377 Disease Relevance 0.61 Pain Relevance 0.18
Subsequent acceleration in growth velocity during GH therapy suggests that a proposed increase in clonidine-induced endogenous GH secretion does not result in an effective growth-promoting stimulus.
Spec (proposed) Positive_regulation (increase) of Localization (secretion) of GH associated with clonidine
12) Confidence 0.65 Published 1993 Journal J. Pediatr. Section Abstract Doc Link 8419612 Disease Relevance 0.07 Pain Relevance 0.75
Subsequent acceleration in growth velocity during GH therapy suggests that a proposed increase in clonidine-induced endogenous GH secretion does not result in an effective growth-promoting stimulus.
Positive_regulation (induced) of Localization (secretion) of GH associated with clonidine
13) Confidence 0.65 Published 1993 Journal J. Pediatr. Section Abstract Doc Link 8419612 Disease Relevance 0.07 Pain Relevance 0.72
A number of agents such as oral GH-releasing peptides (GHRPs) increase GH secretion; they may be an alternative to GH treatment in the future.
Positive_regulation (increase) of Localization (secretion) of GH
14) Confidence 0.65 Published 1996 Journal Fundam Clin Pharmacol Section Abstract Doc Link 8902544 Disease Relevance 0.46 Pain Relevance 0.14
In conclusion, low-dose intravenous or oral dexamethasone administration causes a marked GH release in short normal children, probably mediated by hypothalamic structures.
Positive_regulation (causes) of Localization (release) of GH associated with dexamethasone
15) Confidence 0.65 Published 1997 Journal Horm. Res. Section Abstract Doc Link 9195203 Disease Relevance 0 Pain Relevance 0.47
Cholinergic and opioid pathways have been implicated as mediators of the increased growth hormone (GH) release observed during exercise.
Positive_regulation (increased) of Localization (release) of GH associated with opioid
16) Confidence 0.65 Published 1993 Journal J. Appl. Physiol. Section Abstract Doc Link 8226493 Disease Relevance 0 Pain Relevance 0.30
Acute dexamethasone administration (2 mg/m2 i.v. and 4 mg orally) increases growth hormone (GH) release in children.
Positive_regulation (increases) of Localization (release) of growth hormone associated with dexamethasone
17) Confidence 0.65 Published 1997 Journal Horm. Res. Section Abstract Doc Link 9195203 Disease Relevance 0 Pain Relevance 0.22
However, in response to clonidine an increase in GH secretion in all hypertensive and normotensive cases with normal body weight was demonstrated, whereas in all obese hypertensive and normotensive patients no significant GH rise was found.
Positive_regulation (increase) of Localization (secretion) of GH in body associated with body weight, obesity, hypertension and clonidine
18) Confidence 0.64 Published 1988 Journal Clin Exp Hypertens A Section Abstract Doc Link 3286064 Disease Relevance 1.16 Pain Relevance 0.50
In order to estimate the neuroendocrine function of the central nervous system eventually leading to growth hormone (GH) secretion in essential hypertension, 17 patients with mild arterial hypertension (7 obese and 10 with normal body weight) were examined.
Spec (examined) Positive_regulation (leading) of in body Localization (secretion) of GH in central nervous system associated with pressure and volume under development, body weight, obesity, hypertension and central nervous system
19) Confidence 0.64 Published 1988 Journal Clin Exp Hypertens A Section Abstract Doc Link 3286064 Disease Relevance 0.63 Pain Relevance 0.28
Clonidine is not able to enhance GH secretion similar to GHRH in patients chronically treated with steroids.
Positive_regulation (enhance) of Localization (secretion) of GH associated with clonidine
20) Confidence 0.62 Published 1992 Journal Horm. Metab. Res. Section Abstract Doc Link 1398465 Disease Relevance 0.07 Pain Relevance 0.63

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