INT58650

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Context Info
Confidence 0.67
First Reported 1993
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.75
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (NOL3) intracellular (NOL3) cytoplasm (NOL3)
cytosol (NOL3) RNA binding (NOL3) nucleolus (NOL3)
Anatomy Link Frequency
monocyte 1
NOL3 (Homo sapiens)
Pain Link Frequency Relevance Heat
orphanin 15 99.92 Very High Very High Very High
antagonist 6 88.44 High High
anesthesia 1 87.48 High High
narcan 5 86.52 High High
qutenza 4 73.56 Quite High
Opioid 2 62.76 Quite High
agonist 4 52.44 Quite High
Potency 4 51.36 Quite High
cytokine 1 46.28 Quite Low
addiction 4 34.64 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 8 100.00 Very High Very High Very High
Aids-related Complex 2 100.00 Very High Very High Very High
Breast Cancer 6 99.60 Very High Very High Very High
Cancer 101 99.28 Very High Very High Very High
Metastasis 7 94.48 High High
Adhesions 7 89.84 High High
Renal Cancer 55 72.68 Quite High
Solid Tumor 2 55.44 Quite High
Hypoxia 7 53.12 Quite High
Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nociceptin/orphanin FQ (N/OFQ) produces several biological actions by activating the N/OFQ peptide receptor (NOP).
Positive_regulation (activating) of NOP associated with orphanin
1) Confidence 0.67 Published 2005 Journal Peptides Section Abstract Doc Link 15922491 Disease Relevance 0 Pain Relevance 0.17
The apoptotic genes (Figure 4(e)) SPP1 and SFRP1 are candidate tumor suppressors for various cancers; AXL gene is a proto-oncogene, and NOL3 (ARC, apoptosis repressor with CARD domain) is induced in human breast cancer and confers chemo- and radiation-resistance (Mercier et al. 2005).
Positive_regulation (induced) of NOL3 associated with aids-related complex, cancer, breast cancer and apoptosis
2) Confidence 0.59 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.56 Pain Relevance 0
The results obtained are very satisfactory, with an average increase in the arc of mobility of 68 degrees.
Positive_regulation (increase) of arc associated with aids-related complex
3) Confidence 0.45 Published 1993 Journal Arthroscopy Section Abstract Doc Link 8305107 Disease Relevance 0.19 Pain Relevance 0.09
Nociceptin inhibits airway hyperresponsiveness via NOP receptor activation.
Positive_regulation (activation) of NOP receptor associated with orphanin
4) Confidence 0.11 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15351928 Disease Relevance 0 Pain Relevance 0.53
Nociceptin/orphanin FQ stimulates human monocyte chemotaxis via NOP receptor activation.
Positive_regulation (activation) of NOP receptor in monocyte associated with orphanin
5) Confidence 0.07 Published 2005 Journal Peptides Section Title Doc Link 15922491 Disease Relevance 0 Pain Relevance 0.35

General Comments

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