INT58650

Context Info Confidence 0.67 First Reported 1993 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 5 Disease Relevance 1.75 Pain Relevance 1.15

mitochondrion (NOL3) intracellular (NOL3) cytoplasm (NOL3) cytosol (NOL3) RNA binding (NOL3) nucleolus (NOL3)

Anatomy Link Frequency monocyte 1 NOL3 (Homo sapiens)

Pain Link Frequency Relevance Heat orphanin 15 99.92 antagonist 6 88.44 anesthesia 1 87.48 narcan 5 86.52 qutenza 4 73.56 Opioid 2 62.76 agonist 4 52.44 Potency 4 51.36 cytokine 1 46.28 addiction 4 34.64

Disease Link Frequency Relevance Heat Apoptosis 8 100.00 Aids-related Complex 2 100.00 Breast Cancer 6 99.60 Cancer 101 99.28 Metastasis 7 94.48 Adhesions 7 89.84 Renal Cancer 55 72.68 Solid Tumor 2 55.44 Hypoxia 7 53.12 Disease 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Nociceptin/orphanin FQ (N/OFQ) produces several biological actions by activating the N/OFQ peptide receptor (NOP).

Positive_regulation (activating) of NOP associated with orphanin

1) Confidence 0.67 Published 2005 Journal Peptides Section Abstract Doc Link 15922491 Disease Relevance 0 Pain Relevance 0.17

The apoptotic genes (Figure 4(e)) SPP1 and SFRP1 are candidate tumor suppressors for various cancers; AXL gene is a proto-oncogene, and NOL3 (ARC, apoptosis repressor with CARD domain) is induced in human breast cancer and confers chemo- and radiation-resistance (Mercier et al. 2005).

Positive_regulation (induced) of NOL3 associated with aids-related complex, cancer, breast cancer and apoptosis

2) Confidence 0.59 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.56 Pain Relevance 0

The results obtained are very satisfactory, with an average increase in the arc of mobility of 68 degrees.

Positive_regulation (increase) of arc associated with aids-related complex

3) Confidence 0.45 Published 1993 Journal Arthroscopy Section Abstract Doc Link 8305107 Disease Relevance 0.19 Pain Relevance 0.09

Nociceptin inhibits airway hyperresponsiveness via NOP receptor activation.

Positive_regulation (activation) of NOP receptor associated with orphanin

4) Confidence 0.11 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15351928 Disease Relevance 0 Pain Relevance 0.53

Nociceptin/orphanin FQ stimulates human monocyte chemotaxis via NOP receptor activation.

Positive_regulation (activation) of NOP receptor in monocyte associated with orphanin

5) Confidence 0.07 Published 2005 Journal Peptides Section Title Doc Link 15922491 Disease Relevance 0 Pain Relevance 0.35

General Comments

This test has worked.