INT58679

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Context Info
Confidence 0.78
First Reported 1993
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 9.55
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Odc1) lyase activity (Odc1)
Anatomy Link Frequency
kidney 2
macrophages 1
renal cortex 1
proximal 1
granulosa cells 1
Odc1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 4 82.80 Quite High
Inflammatory response 21 81.68 Quite High
Inflammation 78 77.28 Quite High
Inflammatory mediators 25 75.04 Quite High
ischemia 8 48.68 Quite Low
peptic ulcer disease 6 45.24 Quite Low
member 8 2 29.96 Quite Low
Dopamine 1 21.40 Low Low
monoamine 2 18.68 Low Low
imagery 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 191 100.00 Very High Very High Very High
Apoptosis 63 100.00 Very High Very High Very High
Metastasis 10 100.00 Very High Very High Very High
Reprotox - General 1 98 98.48 Very High Very High Very High
Infection 206 98.40 Very High Very High Very High
Familial Adenomatous Polyposis 480 96.64 Very High Very High Very High
Death 15 96.60 Very High Very High Very High
Colon Cancer 72 96.20 Very High Very High Very High
Atrophic Gastritis 5 91.88 High High
Helicobacter Infection 5 88.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that testosterone induces the expression of the ODC gene in the proximal tubule of the renal cortex, leading to the increase in ODC activity in the same region.
Gene_expression (expression) of ODC in renal cortex
1) Confidence 0.78 Published 1993 Journal Histochemistry Section Abstract Doc Link 8307774 Disease Relevance 0 Pain Relevance 0.07
The expression of the ornithine decarboxylase (ODC) gene in the mouse kidney following testosterone treatment was examined using in situ hybridization histochemistry.
Spec (examined) Gene_expression (expression) of ornithine decarboxylase in kidney
2) Confidence 0.78 Published 1993 Journal Histochemistry Section Abstract Doc Link 8307774 Disease Relevance 0 Pain Relevance 0.08
The expression of the ornithine decarboxylase (ODC) gene in the mouse kidney following testosterone treatment was examined using in situ hybridization histochemistry.
Spec (examined) Gene_expression (expression) of ODC in kidney
3) Confidence 0.78 Published 1993 Journal Histochemistry Section Abstract Doc Link 8307774 Disease Relevance 0 Pain Relevance 0.08
Heterogeneous expression of ornithine decarboxylase gene in the proximal tubule of the mouse kidney following testosterone treatment.
Gene_expression (expression) of ornithine decarboxylase in proximal
4) Confidence 0.78 Published 1993 Journal Histochemistry Section Title Doc Link 8307774 Disease Relevance 0 Pain Relevance 0.08
A number of genes which have been previously observed to be over-expressed in tumours (Mycs, Clu)[37], tumor suppressors (Patched, Ptch), or otherwise involved in metastasis or DNA repair: bikunin (Ambp)[38], ornithine decarboxylase gene (Odc), Trefoil factor 1 (Tff1)[39], insulin like growth factor (Igf2) [40] and DNA repair protein 1 (Ddb1), were also differentially expressed in NS398 treated infected mice (Figure 3).
Gene_expression (expressed) of Odc associated with cancer, apoptosis and metastasis
5) Confidence 0.67 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2667483 Disease Relevance 1.22 Pain Relevance 0
A number of genes which have been previously observed to be over-expressed in tumours (Mycs, Clu)[37], tumor suppressors (Patched, Ptch), or otherwise involved in metastasis or DNA repair: bikunin (Ambp)[38], ornithine decarboxylase gene (Odc), Trefoil factor 1 (Tff1)[39], insulin like growth factor (Igf2) [40] and DNA repair protein 1 (Ddb1), were also differentially expressed in NS398 treated infected mice (Figure 3).
Gene_expression (expressed) of ornithine decarboxylase gene associated with cancer, apoptosis and metastasis
6) Confidence 0.67 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2667483 Disease Relevance 1.30 Pain Relevance 0
Our observation of decreases in Odc expression as a result of NS398 treated H. pylori infection in both in vivo and in vitro studies (Table 1 and Figure 4C) is in keeping with this notion.
Gene_expression (expression) of Odc associated with infection
7) Confidence 0.67 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2667483 Disease Relevance 0.67 Pain Relevance 0.08
ODC1 expression is stimulated by LH in granulosa cells and may mediate the effects of LH during the process of follicular development [56].
Gene_expression (expression) of ODC1 in granulosa cells
8) Confidence 0.64 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.30 Pain Relevance 0
Myc expression, in turn, leads to the expression of the polyamine ornithine decarboxylase (ODC) which is a proto-oncogene (Fig. 6).
Gene_expression (expression) of ornithine decarboxylase
9) Confidence 0.58 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 1.12 Pain Relevance 0
Myc expression, in turn, leads to the expression of the polyamine ornithine decarboxylase (ODC) which is a proto-oncogene (Fig. 6).
Gene_expression (expression) of ODC
10) Confidence 0.58 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 1.12 Pain Relevance 0
A number of genes which have been previously observed to be over-expressed in tumours (Mycs, Clu)[37], tumor suppressors (Patched, Ptch), or otherwise involved in metastasis or DNA repair: bikunin (Ambp)[38], ornithine decarboxylase gene (Odc), Trefoil factor 1 (Tff1)[39], insulin like growth factor (Igf2) [40] and DNA repair protein 1 (Ddb1), were also differentially expressed in NS398 treated infected mice (Figure 3).
Gene_expression (expressed) of ornithine decarboxylase gene associated with cancer, apoptosis and metastasis
11) Confidence 0.52 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2667483 Disease Relevance 1.23 Pain Relevance 0
Expression of ODC was decreased in MKN28 cells treated with NS398 (Figure 4C), and was also independent of the presence of a functional type IV section apparatus or VacA.


Gene_expression (Expression) of ODC
12) Confidence 0.52 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2667483 Disease Relevance 0.33 Pain Relevance 0.07
The significance of the gene expression trends of AMD1, BNIP3, GRB10, MARCKSL1, NGRAP1, ODC1, PPP2CB, PPP2R1A, SLC25A4, SLC25A6, and WDR45L that function in cell growth or cell death/survival were not straightforward.
Gene_expression (expression) of ODC1 associated with death
13) Confidence 0.29 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2956710 Disease Relevance 0.90 Pain Relevance 0
Treatment of mice with an inhibitor of ERK phosphorylation attenuated phosphorylation of c-Fos, expression of ODC, and apoptosis in gastric macrophages.
Gene_expression (expression) of ODC in macrophages associated with apoptosis
14) Confidence 0.29 Published 2010 Journal J. Biol. Chem. Section Abstract Doc Link 20410304 Disease Relevance 0.57 Pain Relevance 0
Some of these mechanisms seem to be due to the suppression by resveratrol of cyclooxygenases and ornithine decarboxylase expression, both enzymes that normally promote angiogenesis (Baur and Sinclair 2006).
Gene_expression (expression) of ornithine decarboxylase
15) Confidence 0.06 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546476 Disease Relevance 0.78 Pain Relevance 0

General Comments

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