INT5868

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Context Info
Confidence 0.69
First Reported 1983
Last Reported 2010
Negated 4
Speculated 5
Reported most in Abstract
Documents 122
Total Number 127
Disease Relevance 20.96
Pain Relevance 32.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GNRH1) extracellular space (GNRH1) extracellular region (GNRH1)
cell-cell signaling (GNRH1)
Anatomy Link Frequency
pituitary 13
plasma 7
neurons 6
follicle 4
puncture 3
GNRH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 166 100.00 Very High Very High Very High
Dopamine 47 100.00 Very High Very High Very High
Morphine 32 100.00 Very High Very High Very High
Neuropeptide 26 100.00 Very High Very High Very High
gABA 19 100.00 Very High Very High Very High
Serotonin 8 100.00 Very High Very High Very High
addiction 6 100.00 Very High Very High Very High
Glutamate 4 100.00 Very High Very High Very High
narcan 195 99.98 Very High Very High Very High
Action potential 10 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Prostate Cancer 184 100.00 Very High Very High Very High
Breast Cancer 11 99.90 Very High Very High Very High
Ovarian Cancer 4 99.88 Very High Very High Very High
Polycystic Ovary Syndrome 105 99.84 Very High Very High Very High
Hyperandrogenism 13 99.40 Very High Very High Very High
Dysmenorrhea 14 99.36 Very High Very High Very High
Eating Disorder 17 99.28 Very High Very High Very High
Graves' Ophthalmopathy 4 99.24 Very High Very High Very High
Hyperthyroidism 3 98.92 Very High Very High Very High
Death 12 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Oestradiol also increases the response to progesterone negative feedback, alters GnRH pulse shape and increases GnRH pulse frequency.
Positive_regulation (increases) of GnRH
1) Confidence 0.69 Published 2002 Journal Reprod. Suppl. Section Abstract Doc Link 12698972 Disease Relevance 0 Pain Relevance 0.21
GnRH antagonist inhibited both opioids and GnRH stimulation of hCG release from trophoblast tissue.
Positive_regulation (stimulation) of GnRH associated with antagonist and opioid
2) Confidence 0.69 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8114013 Disease Relevance 0 Pain Relevance 0.77
Interestingly, naloxone not only increased GnRH pulse amplitude, but also prolonged the duration of GnRH release during a pulse.
Positive_regulation (increased) of GnRH associated with narcan
3) Confidence 0.68 Published 1995 Journal Endocrinology Section Abstract Doc Link 7750462 Disease Relevance 0 Pain Relevance 0.53
Naloxone treatment had no effect on GnRH pulse frequency, but significantly increased GnRH pulse size.
Positive_regulation (increased) of GnRH associated with narcan
4) Confidence 0.68 Published 1995 Journal Endocrinology Section Abstract Doc Link 7750462 Disease Relevance 0 Pain Relevance 0.50
The increase in GnRH pulse duration was caused by a prolongation of both the plateau and declining phases of the GnRH pulse.
Positive_regulation (increase) of GnRH
5) Confidence 0.68 Published 1995 Journal Endocrinology Section Abstract Doc Link 7750462 Disease Relevance 0 Pain Relevance 0.53
Estradiol treatment decreased GnRH pulse size and increased GnRH pulse frequency.
Positive_regulation (increased) of GnRH
6) Confidence 0.68 Published 1995 Journal Endocrinology Section Abstract Doc Link 7750462 Disease Relevance 0 Pain Relevance 0.45
In addition to these effects on GnRH release during a pulse, naloxone increased the amount of GnRH collected between pulses in both experiments.
Positive_regulation (increased) of GnRH associated with narcan
7) Confidence 0.68 Published 1995 Journal Endocrinology Section Abstract Doc Link 7750462 Disease Relevance 0 Pain Relevance 0.50
At puberty the pulsatile GnRH secretion, and the subsequent episodic pituitary gonadotropin secretion, which is necessary for normal gonadal development and function, is triggered by the activation of the GnRH pulse generator.
Positive_regulation (activation) of GnRH in pituitary
8) Confidence 0.68 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2958977 Disease Relevance 0 Pain Relevance 0.17
Activation of GnRH receptors led to biphasic changes in cytosolic Ca2+ concentration ([Ca2+]i), with an early, extracellular Ca(2+)-independent peak and a sustained, extracellular Ca(2+)-dependent phase.
Positive_regulation (Activation) of GnRH
9) Confidence 0.67 Published 1999 Journal Mol. Endocrinol. Section Abstract Doc Link 10194765 Disease Relevance 0 Pain Relevance 0.43
Norepinephrine (NE) produced a dose-related stimulation of GnRH from P-AH slices, but not from pituitary fragments.
Positive_regulation (stimulation) of GnRH in pituitary
10) Confidence 0.65 Published 1992 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 1348716 Disease Relevance 0 Pain Relevance 0.40
The increase in LHRH stimulates the anterior pituitary to secrete LH and follicle-stimulating hormone into the systemic circulation (Denmeade and Isaacs 2004).
Positive_regulation (increase) of LHRH in follicle
11) Confidence 0.63 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504071 Disease Relevance 0.08 Pain Relevance 0.15
One patient showed no increase in IR-LHRH or LH with BRCR therapy and failed to show a decrease in serum PRL to normal levels after five days of this treatment.
Neg (no) Positive_regulation (increase) of IR-LHRH
12) Confidence 0.60 Published 1987 Journal J Reprod Med Section Abstract Doc Link 3550065 Disease Relevance 0.28 Pain Relevance 0.11
We conclude, therefore, that the EOPs that mediate progesterone negative feedback on pulsatile GnRH secretion are not involved in blockade of activation of the E2-induced GnRH surge by progesterone, but do appear to be part of the mechanism by which progesterone disrupts the transmission stage.
Positive_regulation (activation) of GnRH
13) Confidence 0.57 Published 2001 Journal Endocrinology Section Abstract Doc Link 11713217 Disease Relevance 0 Pain Relevance 0.24
However, human RFRP-3, which is identical in sequence to sheep RFRP-3, potently inhibits gonadotropin secretion in vivo in sheep and GnRH stimulation of gonadotropin secretion from cultured sheep pituitary cells [26], [27].
Positive_regulation (stimulation) of GnRH in pituitary
14) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791420 Disease Relevance 0.06 Pain Relevance 0.06
In the reproductive system, endogenous opioid peptides are involved in the steroid feedback control of GnRH pulses and the induction of the GnRH surge.
Positive_regulation (induction) of GnRH in reproductive system associated with endogenous opioid
15) Confidence 0.57 Published 2007 Journal Endocrinology Section Abstract Doc Link 17615146 Disease Relevance 0.19 Pain Relevance 0.41
Steroid concentrating neurons under the direction of ovarian steroid milieu promote LHRH accumulation and either independently or in association with the opioid peptide neurons modulate the episodic LHRH discharge.
Positive_regulation (accumulation) of LHRH in neurons associated with opioid
16) Confidence 0.55 Published 1985 Journal J. Steroid Biochem. Section Abstract Doc Link 2934578 Disease Relevance 0 Pain Relevance 0.20
Both LD photoperiod and T increased both LH and GnRH (P < 0.01) interpulse-interval (IPI).
Positive_regulation (increased) of GnRH
17) Confidence 0.52 Published 2000 Journal Domest. Anim. Endocrinol. Section Abstract Doc Link 10701767 Disease Relevance 0 Pain Relevance 0.62
LD photoperiod (P < 0.01), T (P < 0.01) and naloxone (P < 0.01) all increased LH pulse amplitude whereas only naloxone increased GnRH pulse amplitude (P < 0.01).
Positive_regulation (increased) of GnRH associated with narcan
18) Confidence 0.52 Published 2000 Journal Domest. Anim. Endocrinol. Section Abstract Doc Link 10701767 Disease Relevance 0 Pain Relevance 0.56
Constant infusion of naloxone (60 min) induced a sustained increase in GnRH release, which was promptly inhibited by a pulse of beta-endorphin administered halfway during the naloxone infusion.
Positive_regulation (increase) of GnRH associated with narcan
19) Confidence 0.50 Published 1983 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6311863 Disease Relevance 0 Pain Relevance 0.53
Iatrogenic hypoestrogenism is the fundamental mechanism through which GnRH agonists induce regression of the exquisitely estrogen-dependent endometriotic lesions.
Positive_regulation (induce) of GnRH associated with endometriosis, iatrogenic and agonist
20) Confidence 0.50 Published 1997 Journal Semin. Reprod. Endocrinol. Section Abstract Doc Link 9383836 Disease Relevance 0.52 Pain Relevance 0.40

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