INT58692

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Context Info
Confidence 0.42
First Reported 1993
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 10.16
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CD8A) plasma membrane (CD8A)
Anatomy Link Frequency
T-cell 8
blood 4
lymphocytes 2
memory T-cells 2
CD8A (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 128 100.00 Very High Very High Very High
cytokine 127 94.72 High High
antagonist 5 91.40 High High
cINOD 2 82.24 Quite High
Inflammation 101 70.72 Quite High
chemokine 9 70.00 Quite High
Inflammatory mediators 4 58.80 Quite High
bradykinin 3 50.96 Quite High
Central nervous system 26 42.32 Quite Low
agonist 34 38.48 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 129 100.00 Very High Very High Very High
INFLAMMATION 122 100.00 Very High Very High Very High
Cold Sores 369 99.44 Very High Very High Very High
Diffuse Cutaneous Leishmaniasis 74 99.40 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 669 99.04 Very High Very High Very High
Infection 292 98.92 Very High Very High Very High
Chlamydia Infection 88 98.28 Very High Very High Very High
Disease Progression 11 97.48 Very High Very High Very High
Pulmonary Disease 51 97.10 Very High Very High Very High
Asthma 39 96.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We longitudinally examined a group of rhesus macaques infected with SIV and CD8+ cell depleted (n?
Spec (examined) Regulation (infected) of Gene_expression (cell) of CD8
1) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866543 Disease Relevance 0.59 Pain Relevance 0.03
Virus-specific CD8+ T-cell response in the blood
Regulation (Virus) of Gene_expression (response) of CD8 in blood
2) Confidence 0.39 Published 2001 Journal BMC Infect Dis Section Body Doc Link PMC37356 Disease Relevance 0.19 Pain Relevance 0
Virus-specific CD8+ T-cell response in the blood
Regulation (specific) of Gene_expression (response) of CD8 in blood
3) Confidence 0.39 Published 2001 Journal BMC Infect Dis Section Body Doc Link PMC37356 Disease Relevance 0.19 Pain Relevance 0
To date, the mechanism responsible for the reduced presence of CD8 in lesions of DCL patients remains unclear.
Regulation (responsible) of Gene_expression (presence) of CD8 associated with diffuse cutaneous leishmaniasis
4) Confidence 0.30 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 1.17 Pain Relevance 0
TCR diversity spectratype analysis was performed on sorted CD4+ and CD8+ populations before and after (day 21) rhIL-7 therapy in 6 subjects treated at either 30 or 60 ?
Regulation (performed) of Gene_expression (populations) of CD8
5) Confidence 0.27 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442646 Disease Relevance 0 Pain Relevance 0
Finally, changes in T-cell receptor expression as a person ages, such as increased expression of the CCR5 co-receptor, is important in the pathogenesis of HIV infection and could also influence disease progression (Kalayjian et al 2003; Yung and Mo 2003).
Regulation (changes) of Gene_expression (expression) of T-cell receptor in T-cell associated with acquired immune deficiency syndrome or hiv infection, disease progression and infection
6) Confidence 0.23 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682378 Disease Relevance 2.06 Pain Relevance 0
This suggests that factors other than IL-7 can effectively drive CD8+ T-cell expansion, and it is notable that transient expansion of CD8+ memory T-cells did occur in RA patients.
Regulation (drive) of Gene_expression (expansion) of CD8 in memory T-cells associated with rheumatoid arthritis
7) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.62 Pain Relevance 0.20
The effects of nonsteroidal antiinflammatory drug therapy in early rheumatoid arthritis on serum levels of soluble interleukin 2 receptor, CD4, and CD8.
Regulation (effects) of Gene_expression (levels) of CD8 associated with inflammation and rheumatoid arthritis
8) Confidence 0.15 Published 1993 Journal J. Rheumatol. Section Title Doc Link 8308770 Disease Relevance 0.48 Pain Relevance 0.27
Generation of antigen-specific CD8+ T cell lines after MACS sorting of HLA-B27 tetramer-positive T cells
Regulation (specific) of Gene_expression (lines) of CD8 in T cells
9) Confidence 0.14 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064864 Disease Relevance 0.38 Pain Relevance 0.03
production and the presence of CD4+ and CD8+ T cells are key regulators of viral clearance during acute infection.
Regulation (regulators) of Gene_expression (production) of CD8 in T cells associated with infection
10) Confidence 0.11 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.28 Pain Relevance 0.34
Finally, changes in T-cell receptor expression as a person ages, such as increased expression of the CCR5 co-receptor, is important in the pathogenesis of HIV infection and could also influence disease progression (Kalayjian et al 2003; Yung and Mo 2003).
Regulation (important) of Gene_expression (expression) of T-cell receptor in T-cell associated with acquired immune deficiency syndrome or hiv infection, disease progression and infection
11) Confidence 0.10 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682378 Disease Relevance 2.21 Pain Relevance 0
No significant changes in the levels of CD4, CD8, CD95 was observed in the co-culture conditions tested.
Neg (No) Regulation (changes) of Gene_expression (levels) of CD8
12) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.09 Pain Relevance 0
Viral infections, which may play a role in both asthma and COPD, induce M2 dysfunction through neuraminidases that cleave portions of the M2 receptor, and through as yet incompletely characterized mechanisms involving macrophages, CD8+ lymphocytes, and possibly IFN-?
Spec (possibly) Regulation (involving) of Gene_expression (lymphocytes) of CD8 in lymphocytes associated with asthma, pulmonary disease and viral infection
13) Confidence 0.07 Published 2006 Journal Respir Res Section Body Doc Link PMC1479816 Disease Relevance 0.91 Pain Relevance 0.14

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