INT58720

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Context Info
Confidence 0.50
First Reported 1994
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 0.19
Pain Relevance 2.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

growth (SAFB) nucleolus (SAFB) RNA binding (SAFB)
nucleus (SAFB) DNA binding (SAFB)
Anatomy Link Frequency
apoptotic cells 1
SAFB (Homo sapiens)
Pain Link Frequency Relevance Heat
Action potential 10 99.52 Very High Very High Very High
Clonidine 14 99.12 Very High Very High Very High
lidocaine 16 98.64 Very High Very High Very High
local anesthetic 4 89.28 High High
headache 6 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 141 77.92 Quite High
Breast Cancer 114 50.00 Quite Low
Cancer 39 50.00 Quite Low
Rheumatoid Arthritis 78 5.00 Very Low Very Low Very Low
Disease 36 5.00 Very Low Very Low Very Low
Advanced Or Metastatic Breast Cancer 15 5.00 Very Low Very Low Very Low
Toxicity 15 5.00 Very Low Very Low Very Low
Headache 6 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 6 5.00 Very Low Very Low Very Low
Metastasis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clonidine, at concentrations from 0.05 to 50 mumol/l, decreased the fast HAP, while the AP amplitude was unchanged.
Negative_regulation (decreased) of HAP associated with action potential and clonidine
1) Confidence 0.50 Published 1994 Journal Pharmacology Section Abstract Doc Link 8309984 Disease Relevance 0 Pain Relevance 1.16
In the presence of lidocaine (500 mumol/l), clonidine at concentrations from 0.05 to 500 mumol/l decreased the HAP amplitude, without modifying the lidocaine-induced shape of the HAP.
Negative_regulation (decreased) of HAP associated with lidocaine and clonidine
2) Confidence 0.37 Published 1994 Journal Pharmacology Section Abstract Doc Link 8309984 Disease Relevance 0 Pain Relevance 1.54
The mean number of apoptotic cells was higher in samples with pure HAp, slightly decreased in samples HAp with lidocaine and significantly lower in controls.
Negative_regulation (decreased) of HAp in apoptotic cells
3) Confidence 0.10 Published 2009 Journal Stomatologija Section Body Doc Link 20179398 Disease Relevance 0 Pain Relevance 0
Single-agent trastuzumab caused partial inhibition of ERE activity comparable with that of tamoxifen, implicating peptide growth factor signaling pathway-driven ER activation in these cells; however, adding trastuzumab to tamoxifen did not further inhibit ERE activity.
Spec (partial) Negative_regulation (inhibition) of ERE
4) Confidence 0.01 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2949655 Disease Relevance 0.06 Pain Relevance 0
Treatment with single-agent atRA caused a profound inhibition of ERE activity, comparable with the ER downregulator Faslodex (Figure 10).
Negative_regulation (inhibition) of ERE
5) Confidence 0.01 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2949655 Disease Relevance 0.05 Pain Relevance 0
Single-agent trastuzumab caused partial inhibition of ERE activity comparable with that of tamoxifen, implicating peptide growth factor signaling pathway-driven ER activation in these cells; however, adding trastuzumab to tamoxifen did not further inhibit ERE activity.
Negative_regulation (inhibit) of ERE
6) Confidence 0.01 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2949655 Disease Relevance 0.08 Pain Relevance 0

General Comments

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