INT58750

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Context Info
Confidence 0.47
First Reported 1994
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 18
Disease Relevance 5.48
Pain Relevance 4.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (GAL) Golgi apparatus (GAL) cellular_component (GAL)
response to stress (GAL) cytoplasm (GAL)
GAL (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 40 100.00 Very High Very High Very High
Somatostatin 12 100.00 Very High Very High Very High
substance P 6 100.00 Very High Very High Very High
Calcitonin gene-related peptide 4 100.00 Very High Very High Very High
Enkephalin 3 98.68 Very High Very High Very High
depression 27 98.58 Very High Very High Very High
opiate 15 96.92 Very High Very High Very High
withdrawal 6 96.64 Very High Very High Very High
noradrenaline 5 95.92 Very High Very High Very High
Serotonin 101 95.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Natriuresis 3 99.24 Very High Very High Very High
Depression 39 98.58 Very High Very High Very High
Anxiety Disorder 18 97.98 Very High Very High Very High
Stress 10 97.36 Very High Very High Very High
Convulsion 8 95.56 Very High Very High Very High
Pain 18 95.12 Very High Very High Very High
Disease 23 94.44 High High
Galactorrhea 372 90.96 High High
Injury 3 85.84 High High
Aggression 1 84.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, galanin binding in whole cells was completely reversible within 1 hr.
galanin Binding (binding) of
1) Confidence 0.47 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9808667 Disease Relevance 0.07 Pain Relevance 0.25
A scintillation proximity assay revealed that 125I-human galanin binding in membranes reached steady-state within 2 to 2.5 hr; however, only 50% of galanin radiolabel dissociated from the receptors by excess galanin or guanosine 5'-O-3-thiotriphosphate even after 20 hr.
galanin Binding (binding) of
2) Confidence 0.47 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9808667 Disease Relevance 0.08 Pain Relevance 0.24
Competition binding assays showed that galanin-like peptides bound with picomolar affinities in membranes and whole cells.
galanin Binding (bound) of
3) Confidence 0.47 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9808667 Disease Relevance 0.06 Pain Relevance 0.29
SO demonstrated immunoreactivity for VIP, PHI (PHM), neuropeptide Y, CGRP, galanin, somatostatin, substance P, and enkephalin, but no immunoreactivity was observed for bombesin.
galanin Binding (immunoreactivity) of associated with somatostatin, neuropeptide, enkephalin, substance p and calcitonin gene-related peptide
4) Confidence 0.36 Published 1994 Journal Dig. Dis. Sci. Section Abstract Doc Link 8313811 Disease Relevance 0.52 Pain Relevance 0.80
A number of other neurotrasmitters and neuropeptides can also modulate prolactin secretion, among which galanin, endothelin, TGFbeta1, angiotensin, somatostatin, substance P, neurotensin, calcitonin, EGF, natriuretic atrial peptide, bombesin, colecistokinine, acetylcholine, vasopressin (Figure 1).
galanin Binding (angiotensin) of associated with natriuresis, somatostatin, neuropeptide and substance p
5) Confidence 0.36 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.33 Pain Relevance 0.27
A number of other neurotrasmitters and neuropeptides can also modulate prolactin secretion, among which galanin, endothelin, TGFbeta1, angiotensin, somatostatin, substance P, neurotensin, calcitonin, EGF, natriuretic atrial peptide, bombesin, colecistokinine, acetylcholine, vasopressin (Figure 1).
galanin Binding (neurotensin) of associated with natriuresis, somatostatin, neuropeptide and substance p
6) Confidence 0.36 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.34 Pain Relevance 0.27
A number of other neurotrasmitters and neuropeptides can also modulate prolactin secretion, among which galanin, endothelin, TGFbeta1, angiotensin, somatostatin, substance P, neurotensin, calcitonin, EGF, natriuretic atrial peptide, bombesin, colecistokinine, acetylcholine, vasopressin (Figure 1).
galanin Binding (which) of associated with natriuresis, somatostatin, neuropeptide and substance p
7) Confidence 0.36 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.27 Pain Relevance 0.27
Galnon is a low-molecular weight galanin receptor ligand, with affinity towards the three galanin receptors in the micromolar range.
galanin Binding (ligand) of
8) Confidence 0.36 Published 2005 Journal Neuropeptides Section Abstract Doc Link 15944006 Disease Relevance 0.18 Pain Relevance 0.12
Galnon is a low-molecular weight galanin receptor ligand, with affinity towards the three galanin receptors in the micromolar range.
galanin Binding (affinity) of
9) Confidence 0.36 Published 2005 Journal Neuropeptides Section Abstract Doc Link 15944006 Disease Relevance 0.19 Pain Relevance 0.13
To evaluate the human galanin receptor 1 as a potential therapeutic target, we fully characterized its interaction with several galanin-like peptides.
galanin Binding (interaction) of
10) Confidence 0.35 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9808667 Disease Relevance 0.10 Pain Relevance 0.18
One concept to emerge from this literature is that galanin recruitment during extreme behavioral and physiological provocations such as stress and opiate withdrawal may serve to attenuate negative emotional states caused by noradrenergic hyperactivation.
galanin Binding (recruitment) of associated with stress, opiate and withdrawal
11) Confidence 0.33 Published 2006 Journal Amino Acids Section Abstract Doc Link 16733616 Disease Relevance 0.97 Pain Relevance 0.55
This review will provide an overview of the comprehensive, pharmacological characterization of endogenous and synthetic galanin receptor ligands and their interactions with the galanin receptors, a summary of the various (pleiotropic) biological actions of galanin and GALP (and alarin), and briefly discuss the implications of pathological changes for health and disease and potential clinical therapeutics.
galanin Binding (interactions) of associated with disease
12) Confidence 0.20 Published 2007 Journal Pharmacol. Ther. Section Abstract Doc Link 17604107 Disease Relevance 0.17 Pain Relevance 0.03
anxiety-related behaviors, depression-related behaviors, sexual behaviors, and feeding. [3] The activity of galanin is modulated by its interaction with
galanin Binding (interaction) of associated with depression and anxiety disorder
13) Confidence 0.15 Published 2007 Journal Bioinformation Section Body Doc Link PMC2248450 Disease Relevance 0.56 Pain Relevance 0.39
interaction of galanin with its receptors.
galanin Binding (interaction) of
14) Confidence 0.15 Published 2007 Journal Bioinformation Section Body Doc Link PMC2248450 Disease Relevance 0.47 Pain Relevance 0.33
Therefore, this work is an attempt to predict structural information on galanin at the N-terminal region

(N-gal) and studying its interaction with galanin receptors, which would be useful for exploring the functional aspects of galanin.


galanin Binding (interaction) of
15) Confidence 0.15 Published 2007 Journal Bioinformation Section Body Doc Link PMC2248450 Disease Relevance 0.43 Pain Relevance 0.28
Galanin, a neuroendocrine peptide with a multitude of functions, binds to and acts on specific G-protein coupled receptors.
Galanin Binding (binds) of
16) Confidence 0.06 Published 1997 Journal Life Sci. Section Abstract Doc Link 9126874 Disease Relevance 0.23 Pain Relevance 0.18
Determination of structural components of galanin receptors required for binding of the peptide ligand as carried out recently will facilitate the screening and design of molecules specifically acting on galaninergic systems with therapeutic potential in Alzheimer's disease, feeding disorders, pain and depression.
galanin Binding (binding) of associated with pain, depression and disease
17) Confidence 0.04 Published 1997 Journal Life Sci. Section Abstract Doc Link 9126874 Disease Relevance 0.50 Pain Relevance 0.34
These constructs were transfected together with a luciferase reporter UAS plasmid containing binding sites for the GAL-DBD.


GAL-DBD Binding (binding) of
18) Confidence 0.01 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0

General Comments

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