INT58751

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Context Info
Confidence 0.70
First Reported 1994
Last Reported 2004
Negated 2
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 2.51
Pain Relevance 2.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SST) extracellular region (SST) cell-cell signaling (SST)
Anatomy Link Frequency
mononuclear cell 3
neutrophil 1
SST (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 13 100.00 Very High Very High Very High
Neuropeptide 5 100.00 Very High Very High Very High
substance P 5 100.00 Very High Very High Very High
Calcitonin gene-related peptide 4 100.00 Very High Very High Very High
Enkephalin 3 100.00 Very High Very High Very High
imagery 2 100.00 Very High Very High Very High
narcan 20 97.74 Very High Very High Very High
fibrosis 1 91.72 High High
abdominal pain 1 86.60 High High
antagonist 2 84.24 Quite High
Disease Link Frequency Relevance Heat
Schistosomiasis 3 99.28 Very High Very High Very High
Carcinoid 6 97.20 Very High Very High Very High
Metastasis 1 97.20 Very High Very High Very High
Diarrhoea 2 95.76 Very High Very High Very High
Increased Venous Pressure Under Development 1 95.20 Very High Very High Very High
Hemorrhage 1 93.64 High High
Fibrosis 1 91.72 High High
Aggression 1 90.80 High High
Fever 1 89.28 High High
Vomiting 1 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The activity of somatostatin is mediated via binding to specific cell surface receptors.
Positive_regulation (mediated) of somatostatin Binding (binding) of associated with somatostatin
1) Confidence 0.70 Published 2001 Journal Trop. Med. Int. Health Section Abstract Doc Link 11737838 Disease Relevance 0.87 Pain Relevance 0.45
Scintigraphs with 131I-metaiodobenzylguanidine (131I-MIBG) which is accumulated in the argentaffin granules of the cell, as well as with 111In-pentetreotide for the imaging of somatostatin receptors on the cell surface, are positive in a large proportion of carcinoid patients.
Positive_regulation (accumulated) of somatostatin Binding (imaging) of associated with carcinoid, somatostatin and imagery
2) Confidence 0.49 Published 1996 Journal Eur. J. Cancer Section Abstract Doc Link 8943676 Disease Relevance 1.08 Pain Relevance 0.22
Naloxone induced peripheral blood nonadherent mononuclear cell and neutrophil chemotaxis at nanomolar concentrations and deactivated their migration toward beta-endorphin, angiotensin II, somatostatin, or interleukin-8 but not toward RANTES, vasoactive intestinal peptide, or substance P.
Neg (not) Positive_regulation (deactivated) of somatostatin Neg (not) Binding (migration) of in mononuclear cell associated with somatostatin, narcan and substance p
3) Confidence 0.49 Published 2004 Journal Biochemistry Section Abstract Doc Link 14705951 Disease Relevance 0 Pain Relevance 0.58
SO demonstrated immunoreactivity for VIP, PHI (PHM), neuropeptide Y, CGRP, galanin, somatostatin, substance P, and enkephalin, but no immunoreactivity was observed for bombesin.
Positive_regulation (observed) of somatostatin Binding (immunoreactivity) of associated with somatostatin, neuropeptide, enkephalin, substance p and calcitonin gene-related peptide
4) Confidence 0.38 Published 1994 Journal Dig. Dis. Sci. Section Abstract Doc Link 8313811 Disease Relevance 0.57 Pain Relevance 0.85
Naloxone induced peripheral blood nonadherent mononuclear cell and neutrophil chemotaxis at nanomolar concentrations and deactivated their migration toward beta-endorphin, angiotensin II, somatostatin, or interleukin-8 but not toward RANTES, vasoactive intestinal peptide, or substance P.
Neg (not) Positive_regulation (deactivated) of somatostatin in neutrophil Neg (not) Binding (migration) of in mononuclear cell associated with somatostatin, narcan and substance p
5) Confidence 0.17 Published 2004 Journal Biochemistry Section Abstract Doc Link 14705951 Disease Relevance 0 Pain Relevance 0.58

General Comments

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