INT58752

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Context Info
Confidence 0.49
First Reported 1994
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.73
Pain Relevance 2.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CALCA) aging (CALCA) extracellular region (CALCA)
nucleus (CALCA) intracellular (CALCA) cell-cell signaling (CALCA)
CALCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 216 100.00 Very High Very High Very High
Neuropeptide 35 100.00 Very High Very High Very High
Enkephalin 3 100.00 Very High Very High Very High
Somatostatin 3 100.00 Very High Very High Very High
substance P 3 100.00 Very High Very High Very High
antagonist 12 90.24 High High
Migraine 3 83.92 Quite High
Potency 14 5.00 Very Low Very Low Very Low
agonist 11 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aggression 1 90.80 High High
Disease 5 88.08 High High
Headache 2 83.92 Quite High
Death 1 83.04 Quite High
Gallstones 1 79.04 Quite High
Pancreatitis 1 76.08 Quite High
Carcinoma 1 73.04 Quite High
Increased Venous Pressure Under Development 2 5.00 Very Low Very Low Very Low
Heart Disease 1 5.00 Very Low Very Low Very Low
Neuroblastoma 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the study presented here, conformational and structural features in CGRP(27-37)-NH(2) analogues that are important for hCGRP(1) receptor binding were explored.
Positive_regulation (important) of CGRP Binding (binding) of associated with calcitonin gene-related peptide
1) Confidence 0.49 Published 2001 Journal Biochemistry Section Abstract Doc Link 11444978 Disease Relevance 0.16 Pain Relevance 0.76
SO demonstrated immunoreactivity for VIP, PHI (PHM), neuropeptide Y, CGRP, galanin, somatostatin, substance P, and enkephalin, but no immunoreactivity was observed for bombesin.
Positive_regulation (observed) of CGRP Binding (immunoreactivity) of associated with somatostatin, neuropeptide, enkephalin, substance p and calcitonin gene-related peptide
2) Confidence 0.47 Published 1994 Journal Dig. Dis. Sci. Section Abstract Doc Link 8313811 Disease Relevance 0.57 Pain Relevance 0.85
In this study, we identify two specific leucine residues within this N-terminal domain of the CLR that significantly contribute to the high affinity binding of CGRP without appreciably affecting receptor function.


Positive_regulation (contribute) of CGRP Binding (binding) of associated with calcitonin gene-related peptide
3) Confidence 0.42 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0 Pain Relevance 0.48

General Comments

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