INT58756

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Context Info
Confidence 0.48
First Reported 1994
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 7.17
Pain Relevance 3.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (GPI) small molecule metabolic process (GPI) carbohydrate metabolic process (GPI)
cytoplasm (GPI) cytosol (GPI) extracellular space (GPI)
Anatomy Link Frequency
macrophages 1
joint 1
B cells 1
central nervous system 1
GPI (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 8 100.00 Very High Very High Very High
deep brain stimulation 88 99.96 Very High Very High Very High
Neuropeptide 5 99.68 Very High Very High Very High
Calcitonin gene-related peptide 4 99.04 Very High Very High Very High
Somatostatin 3 98.44 Very High Very High Very High
substance P 3 97.88 Very High Very High Very High
rheumatoid arthritis 26 97.32 Very High Very High Very High
Enkephalin 3 97.20 Very High Very High Very High
Inflammation 14 96.00 Very High Very High Very High
cytokine 22 95.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cognitive Disorder 18 100.00 Very High Very High Very High
Hemolytic Anemia 18 100.00 Very High Very High Very High
Disease Progression 2 99.76 Very High Very High Very High
Hematological Disease 28 99.66 Very High Very High Very High
Paroxysmal Nocturnal Hemoglobinuria 316 99.38 Very High Very High Very High
Dyskinesias 39 98.48 Very High Very High Very High
Rheumatoid Arthritis 26 97.32 Very High Very High Very High
Immunization 3 97.20 Very High Very High Very High
INFLAMMATION 22 96.00 Very High Very High Very High
Parasitemia 14 95.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Glucose-6-phosphate isomerase (GPI) deficiency, an autosomal recessive genetic disorder with the typical manifestation of nonspherocytic haemolytic anaemia, can be associated in some cases with neurological impairment.
GPI Binding (associated) of associated with hemolytic anemia
1) Confidence 0.48 Published 1998 Journal Hum. Genet. Section Abstract Doc Link 9856489 Disease Relevance 0.17 Pain Relevance 0.12
Glucose-6-phosphate isomerase (GPI) deficiency, an autosomal recessive genetic disorder with the typical manifestation of nonspherocytic haemolytic anaemia, can be associated in some cases with neurological impairment.
Glucose-6-phosphate isomerase Binding (associated) of associated with hemolytic anemia
2) Confidence 0.48 Published 1998 Journal Hum. Genet. Section Abstract Doc Link 9856489 Disease Relevance 0.17 Pain Relevance 0.12
SO demonstrated immunoreactivity for VIP, PHI (PHM), neuropeptide Y, CGRP, galanin, somatostatin, substance P, and enkephalin, but no immunoreactivity was observed for bombesin.
PHI Binding (immunoreactivity) of associated with somatostatin, neuropeptide, enkephalin, substance p and calcitonin gene-related peptide
3) Confidence 0.36 Published 1994 Journal Dig. Dis. Sci. Section Abstract Doc Link 8313811 Disease Relevance 0.50 Pain Relevance 0.79
In the K/BxN mice, glucose-6-phosphate isomerase (GPI) is an autoantigen recognized by T and B cells.
GPI Binding (recognized) of in B cells
4) Confidence 0.35 Published 2009 Journal Nihon Rinsho Meneki Gakkai Kaishi Section Abstract Doc Link 19252373 Disease Relevance 1.59 Pain Relevance 0.62
Although the STN is now the dominant DBS target, it is unclear whether the GPi, with a less burdensome set of cognitive side effects, might be better for some patients (Anderson et al. 2005).
GPi Spec (might) Binding (be) of associated with cognitive disorder and deep brain stimulation
5) Confidence 0.24 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0.82 Pain Relevance 0.38
GPI may be exposed extracellularly in the joints, or there may be a joint cross-reactive neo-epitope that attracts the binding of the antibodies.
GPI Binding (binding) of in joint
6) Confidence 0.17 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129997 Disease Relevance 0.78 Pain Relevance 0.32
The “off” UPDRS motor score has been reported to improve by 34% to 60% and the UPDRS ADL score by 30%–50% in patients undergoing STN or GPi DBS.
GPi Binding (undergoing) of associated with deep brain stimulation
7) Confidence 0.08 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536542 Disease Relevance 0.50 Pain Relevance 0.36
More recently, the novel fluorescent reagent aerolysin, which specifically binds the GPI anchor, showed even greater sensitivity, with detection limits dropping by 1–2 logs compared with standard flow cytometry (Brodsky et al 2000; Sutherland et al 2007).
GPI Binding (binds) of
8) Confidence 0.03 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721357 Disease Relevance 0.52 Pain Relevance 0
Recently the protein Sho has been demonstrated to be a glycosylphosphatidylinositol (GPI)-anchored neuronal glycoprotein present in the central nervous system (CNS) from early postnatal life that can counteract the neurotoxic effects of either Dpl or ?
GPI Binding (counteract) of in central nervous system associated with central nervous system
9) Confidence 0.03 Published 2010 Journal Neuropathology and Applied Neurobiology Section Body Doc Link PMC3017745 Disease Relevance 0.51 Pain Relevance 0.10
Newer immunosuppressive agents such as the anti-CD52 monoclonal antibody alemtuzumab may be an alternative candidate as immunosuppressant; in this setting, there is no concern about the potential risk of selecting for PNH hematopoiesis, given that the GPI-linked CD52 is not expressed on HSCs.
GPI Binding (linked) of associated with hematological disease and paroxysmal nocturnal hemoglobinuria
10) Confidence 0.03 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721357 Disease Relevance 0.92 Pain Relevance 0
The GPI anchor of the VSG also interacts with the macrophages (via a putative receptor which is still elusive) and induces secretion of pro-inflammatory cytokines [187–189].
GPI Binding (interacts) of in macrophages associated with inflammation and cytokine
11) Confidence 0.03 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 0.67 Pain Relevance 0.20

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