INT58764

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.34
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 2.64
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ANGPT2) signal transduction (ANGPT2) extracellular space (ANGPT2)
extracellular region (ANGPT2) plasma membrane (ANGPT2) nucleus (ANGPT2)
Anatomy Link Frequency
tube 2
superior 2
colon 2
Ciliary 2
ANGPT2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 1 99.52 Very High Very High Very High
antagonist 3 97.60 Very High Very High Very High
headache 4 77.52 Quite High
backache 4 76.72 Quite High
Angina 1 70.44 Quite High
cINOD 2 63.96 Quite High
Dopamine 7 59.96 Quite High
Spinal cord 1 42.72 Quite Low
Central nervous system 9 37.28 Quite Low
midbrain 4 34.80 Quite Low
Disease Link Frequency Relevance Heat
Colon Cancer 4 98.64 Very High Very High Very High
Cough 1 94.88 High High
Pressure And Volume Under Development 52 94.48 High High
Hypertension 24 90.64 High High
Hyperemia 8 88.48 High High
Pathologic Constriction 3 86.64 High High
Hypersensitivity 3 84.08 Quite High
Diarrhoea 7 78.32 Quite High
Headache 4 77.52 Quite High
Low Back Pain 4 76.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, when NSCs are induced to differentiate by the addition of Ciliary Neurotrophic Factor (CNTF), expression of Ang2 is rapidly lost (Figure S1).
Negative_regulation (lost) of Gene_expression (expression) of Ang2 in Ciliary
1) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829079 Disease Relevance 0 Pain Relevance 0
One tube was prechilled and prefilled with the converting enzyme inhibitor bestatin to prevent ex-vivo generation of Ang II.
Negative_regulation (prevent) of Gene_expression (generation) of Ang II in tube
2) Confidence 0.21 Published 2010 Journal Crit Care Section Body Doc Link PMC2875539 Disease Relevance 0.17 Pain Relevance 0.06
It is concluded that meloxicam can reduce the expression of VEGF and Ang-2 at the protein and mRNA level in colon carcinoma cell line.
Negative_regulation (reduce) of Gene_expression (expression) of Ang-2 in colon associated with colon cancer
3) Confidence 0.20 Published 2007 Journal J. Huazhong Univ. Sci. Technol. Med. Sci. Section Abstract Doc Link 17828495 Disease Relevance 0.17 Pain Relevance 0.05
The VEGF and Ang-2 protein levels in supernatants of the culture medium were decreased gradually in a concentration-dependent or time-dependent fashion.
Negative_regulation (decreased) of Gene_expression (levels) of Ang-2 protein
4) Confidence 0.20 Published 2007 Journal J. Huazhong Univ. Sci. Technol. Med. Sci. Section Abstract Doc Link 17828495 Disease Relevance 0.07 Pain Relevance 0.06
Inhibition of Ang II production on day 8 was superior to that of placebo with aliskiren 160 mg, aliskiren 640 mg, and enalapril.
Negative_regulation (Inhibition) of Gene_expression (production) of Ang II in superior
5) Confidence 0.10 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922316 Disease Relevance 0.99 Pain Relevance 0.12
Angiotensin-converting enzyme inhibitors (ACEIs) reduce the production of Ang II by inhibiting the conversion of Ang I to Ang II by these enzymes.
Negative_regulation (reduce) of Gene_expression (production) of Ang II
6) Confidence 0.07 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922316 Disease Relevance 0.28 Pain Relevance 0
In healthy humans, aliskiren of doses between 40 and 640 mg exerts a dose-dependent reduction in PRA, Ang I, and Ang II levels.
Negative_regulation (reduction) of Gene_expression (levels) of Ang II
7) Confidence 0.07 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922316 Disease Relevance 0.09 Pain Relevance 0
In healthy human subjects, doses of between 40 and 640 mg of aliskiren exert a dose-dependent reduction in PRA and Ang I and Ang II levels.
Negative_regulation (reduction) of Gene_expression (levels) of Ang II
8) Confidence 0.07 Published 2008 Journal Pharmacol Rep Section Abstract Doc Link 19066408 Disease Relevance 0.39 Pain Relevance 0.20
ACE inhibitors act within the renin-angiotensin system to prevent the conversion of Ang I to Ang II.
Negative_regulation (prevent) of Gene_expression (conversion) of Ang II
9) Confidence 0.03 Published 1993 Journal J Hypertens Suppl Section Abstract Doc Link 8315523 Disease Relevance 0.47 Pain Relevance 0.19

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox