INT58765

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Context Info
Confidence 0.38
First Reported 1993
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 8.20
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ANGPT2) signal transduction (ANGPT2) extracellular space (ANGPT2)
extracellular region (ANGPT2) plasma membrane (ANGPT2) nucleus (ANGPT2)
Anatomy Link Frequency
plaque 4
blood 3
plasma 3
colon 2
cleavage 2
ANGPT2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 55 97.12 Very High Very High Very High
bradykinin 31 78.28 Quite High
cytokine 14 73.28 Quite High
Angina 9 69.96 Quite High
anesthesia 7 69.20 Quite High
cva 10 67.56 Quite High
isoflurane 1 64.80 Quite High
chemokine 3 63.20 Quite High
Versed 1 61.44 Quite High
butorphanol 1 60.32 Quite High
Disease Link Frequency Relevance Heat
Cancer 351 99.96 Very High Very High Very High
Cv Unclassified Under Development 39 99.48 Very High Very High Very High
Sepsis 45 99.24 Very High Very High Very High
Atherosclerotic Plaque 6 98.88 Very High Very High Very High
Alkalosis 1 98.76 Very High Very High Very High
Syndrome 29 98.08 Very High Very High Very High
Pressure And Volume Under Development 39 97.58 Very High Very High Very High
Increased Venous Pressure Under Development 24 97.48 Very High Very High Very High
Metastasis 110 96.68 Very High Very High Very High
Natriuresis 8 95.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In human cancers, increased expression of Ang2 in tumor cells is closely correlated to tumor cell progression, invasiveness, and metastasis [40, 41].
Positive_regulation (increased) of Gene_expression (expression) of Ang2 associated with cancer and metastasis
1) Confidence 0.38 Published 2011 Journal Pathology Research International Section Body Doc Link PMC3021881 Disease Relevance 1.46 Pain Relevance 0.07
Bartter's syndrome is a rare disorder characterized by normal or low arterial blood pressure (BP), despite marked elevation in plasma renin activity, angiotensin II (Ang-II), and aldosterone, along with hypokalemic metabolic alkalosis.
Positive_regulation (elevation) of in plasma Gene_expression (activity) of Ang-II in blood associated with alkalosis and syndrome
2) Confidence 0.28 Published 1993 Journal J Clin Anesth Section Abstract Doc Link 8373612 Disease Relevance 0.59 Pain Relevance 0.28
We note that the levels of PRA and Ang II measured in our septic subjects are elevated nearly two-fold compared to outpatients with risk factors for vascular disease [33,34], arguing that the acute septic state contributes to RAS activation.
Positive_regulation (elevated) of Gene_expression (levels) of Ang II associated with increased venous pressure under development
3) Confidence 0.23 Published 2010 Journal Crit Care Section Body Doc Link PMC2875539 Disease Relevance 1.07 Pain Relevance 0.03
Increased expression of tissue ACE has been found in the vasculature of subjects with hypertension and in the microvasculature throughout an atherosclerotic plaque, suggesting that the accumulation of ACE in the plaque contributes to increased local production of Ang II (Gibbons 1995; Diet et al 1996).
Positive_regulation (increased) of Gene_expression (production) of Ang II in plaque associated with atherosclerotic plaque and pressure and volume under development
4) Confidence 0.13 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.72 Pain Relevance 0.10
Increased expression of tissue ACE has been found in the vasculature of subjects with hypertension and in the microvasculature throughout an atherosclerotic plaque, suggesting that the accumulation of ACE in the plaque contributes to increased local production of Ang II (Gibbons 1995; Diet et al 1996).
Positive_regulation (contributes) of Gene_expression (production) of Ang II in plaque associated with atherosclerotic plaque and pressure and volume under development
5) Confidence 0.13 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.73 Pain Relevance 0.10
In addition to plasma AngII production, a local RAS has shown to be functional in several organs, leading to production of AngII, which might have a paracrine or autocrine function.
Positive_regulation (leading) of Gene_expression (production) of AngII in plasma
6) Confidence 0.09 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.18 Pain Relevance 0.04
Furthermore, the bound renin has increased catalytic efficiency for the cleavage of angiotensinogen to form Ang I, facilitating Ang II production (by ACE or vascular muscle smooth chymase) at the cell surface.
Positive_regulation (facilitating) of Gene_expression (production) of Ang II in cleavage
7) Confidence 0.08 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922316 Disease Relevance 0.22 Pain Relevance 0
A study investigating the benign pathology of open and closed colon and rectal resection patients demonstrated that both surgical methods are associated with a decrease in Ang 1 and an increase in Ang 2 levels on PODs 1 and 3 such that a significantly greater Ang 1/Ang 2 ratio was noted at both time points.
Positive_regulation (increase) of Gene_expression (levels) of Ang 2 in colon
8) Confidence 0.06 Published 2009 Journal Surg Endosc Section Body Doc Link PMC2814196 Disease Relevance 0.06 Pain Relevance 0
ACE inhibitors act within the renin-angiotensin system to prevent the conversion of Ang I to Ang II.
Positive_regulation (conversion) of Gene_expression (conversion) of Ang II
9) Confidence 0.03 Published 1993 Journal J Hypertens Suppl Section Abstract Doc Link 8315523 Disease Relevance 0.46 Pain Relevance 0.19
Taken together, these data support the strong influence of a local RAAS mechanism operating within the intima and islet for the local production of excess Ang II.
Positive_regulation (excess) of Gene_expression (production) of Ang II
10) Confidence 0.01 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 0.45 Pain Relevance 0
Persistent elevation of intrarenal angiotensin II (ANG II) production with the inability to reduce ANG II in response to a high sodium intake will result in resetting the pressure-natriuresis relationship towards higher blood pressures leading to hypertension [44, 45].
Positive_regulation (elevation) of Gene_expression (production) of ANG II in blood associated with natriuresis and cv unclassified under development
11) Confidence 0.01 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3017903 Disease Relevance 2.25 Pain Relevance 0

General Comments

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