INT58766

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Context Info
Confidence 0.67
First Reported 1993
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 41
Total Number 44
Disease Relevance 21.65
Pain Relevance 4.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ANGPT2) signal transduction (ANGPT2) extracellular space (ANGPT2)
extracellular region (ANGPT2) plasma membrane (ANGPT2) nucleus (ANGPT2)
Anatomy Link Frequency
plasma 3
colon 3
cleavage 2
blood 2
HT-29 2
ANGPT2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 162 100.00 Very High Very High Very High
rheumatoid arthritis 76 99.84 Very High Very High Very High
Angina 35 99.80 Very High Very High Very High
cINOD 12 99.64 Very High Very High Very High
Bioavailability 33 99.52 Very High Very High Very High
bradykinin 55 95.60 Very High Very High Very High
cytokine 53 93.64 High High
Inflammation 163 92.32 High High
Migraine 2 90.64 High High
cva 14 82.96 Quite High
Disease Link Frequency Relevance Heat
Hypertension 146 100.00 Very High Very High Very High
Cancer 940 99.84 Very High Very High Very High
Rheumatoid Arthritis 76 99.84 Very High Very High Very High
Colon Cancer 52 99.84 Very High Very High Very High
Cv General 3 Under Development 44 99.80 Very High Very High Very High
Synovitis 17 99.72 Very High Very High Very High
Sickle Cell Anemia 5 99.64 Very High Very High Very High
Sepsis 89 99.24 Very High Very High Very High
Alkalosis 1 98.76 Very High Very High Very High
Hypoxia 96 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The parallel antipeptide augmentation mimics the shift in the Ang II dose-response curve produced in hypertension studies of the slow pressor effect of Ang II and may be useful in deducing the currently unknown cause of the slow pressor effect.
Gene_expression (produced) of Ang II associated with hypertension
1) Confidence 0.67 Published 1998 Journal Hypertension Section Abstract Doc Link 9495272 Disease Relevance 0.10 Pain Relevance 0.16
The parallel antipeptide augmentation mimics the shift in the Ang II dose-response curve produced in hypertension studies of the slow pressor effect of Ang II and may be useful in deducing the currently unknown cause of the slow pressor effect.
Gene_expression (produced) of Ang II associated with hypertension
2) Confidence 0.67 Published 1998 Journal Hypertension Section Abstract Doc Link 9495272 Disease Relevance 0.10 Pain Relevance 0.17
Angiopoietin-1 (Ang-1) is known to stabilize new vessels, while angiopoietin-2 (Ang-2), in the presence of VEGF, acts as an Ang-1 antagonist, making vessels unstable and promoting vessel sprouting [47].
Gene_expression (antagonist) of Ang-2 in vessels associated with antagonist
3) Confidence 0.45 Published 2010 Journal Respir Res Section Body Doc Link PMC2955663 Disease Relevance 0.54 Pain Relevance 0.13
Angiopoietin-1 (Ang-1) is known to stabilize new vessels, while angiopoietin-2 (Ang-2), in the presence of VEGF, acts as an Ang-1 antagonist, making vessels unstable and promoting vessel sprouting [47].
Gene_expression (antagonist) of angiopoietin-2 in vessels associated with antagonist
4) Confidence 0.45 Published 2010 Journal Respir Res Section Body Doc Link PMC2955663 Disease Relevance 0.55 Pain Relevance 0.13
Under conditions that support self-renewal (in the presence of FGF and FGF + Dll4, for 2 days), fetal NSCs express both Ang1 and Ang2.
Gene_expression (express) of Ang2
5) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829079 Disease Relevance 0 Pain Relevance 0
In contrast, when NSCs are induced to differentiate by the addition of Ciliary Neurotrophic Factor (CNTF), expression of Ang2 is rapidly lost (Figure S1).
Gene_expression (expression) of Ang2 in Ciliary
6) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829079 Disease Relevance 0 Pain Relevance 0
In human cancers, increased expression of Ang2 in tumor cells is closely correlated to tumor cell progression, invasiveness, and metastasis [40, 41].
Gene_expression (expression) of Ang2 associated with cancer and metastasis
7) Confidence 0.42 Published 2011 Journal Pathology Research International Section Body Doc Link PMC3021881 Disease Relevance 1.45 Pain Relevance 0.07
Concerted expression of VEGF and Ang2 resulted in increased microvessel density in solid tumors [40].
Gene_expression (expression) of Ang2 associated with solid tumor
8) Confidence 0.42 Published 2011 Journal Pathology Research International Section Body Doc Link PMC3021881 Disease Relevance 0.75 Pain Relevance 0.05
Bartter's syndrome is a rare disorder characterized by normal or low arterial blood pressure (BP), despite marked elevation in plasma renin activity, angiotensin II (Ang-II), and aldosterone, along with hypokalemic metabolic alkalosis.
Gene_expression (activity) of Ang-II in blood associated with alkalosis and syndrome
9) Confidence 0.37 Published 1993 Journal J Clin Anesth Section Abstract Doc Link 8373612 Disease Relevance 0.59 Pain Relevance 0.28
To investigate the effect of meloxicam, a selected NSAIDs, on cell growth, expression of VEGF and angiopointin-2 (Ang-2) protein in HT-29 cell line, cultured HT-29 cells were treated with meloxicam of various concentrations for various lengths of time.
Gene_expression (expression) of Ang-2 in HT-29 associated with cinod
10) Confidence 0.36 Published 2007 Journal J. Huazhong Univ. Sci. Technol. Med. Sci. Section Abstract Doc Link 17828495 Disease Relevance 0.07 Pain Relevance 0.10
Effects of meloxicam on vascular endothelial growth factor and angiopoietin-2 expression in colon carcinoma cell line HT-29.
Gene_expression (expression) of angiopoietin-2 in colon associated with colon cancer
11) Confidence 0.36 Published 2007 Journal J. Huazhong Univ. Sci. Technol. Med. Sci. Section Title Doc Link 17828495 Disease Relevance 0.10 Pain Relevance 0.10
The mRNA expression of cox-2, VEGF and Ang-2 showed a gradual and concentration-dependent reduction.
Gene_expression (expression) of Ang-2
12) Confidence 0.36 Published 2007 Journal J. Huazhong Univ. Sci. Technol. Med. Sci. Section Abstract Doc Link 17828495 Disease Relevance 0.07 Pain Relevance 0.06
It is concluded that meloxicam can reduce the expression of VEGF and Ang-2 at the protein and mRNA level in colon carcinoma cell line.
Gene_expression (expression) of Ang-2 in colon associated with colon cancer
13) Confidence 0.36 Published 2007 Journal J. Huazhong Univ. Sci. Technol. Med. Sci. Section Abstract Doc Link 17828495 Disease Relevance 0.17 Pain Relevance 0.05
The VEGF and Ang-2 protein levels in supernatants of the culture medium were decreased gradually in a concentration-dependent or time-dependent fashion.
Gene_expression (levels) of Ang-2 protein
14) Confidence 0.31 Published 2007 Journal J. Huazhong Univ. Sci. Technol. Med. Sci. Section Abstract Doc Link 17828495 Disease Relevance 0.07 Pain Relevance 0.06
One tube was prechilled and prefilled with the converting enzyme inhibitor bestatin to prevent ex-vivo generation of Ang II.
Gene_expression (generation) of Ang II in tube
15) Confidence 0.30 Published 2010 Journal Crit Care Section Body Doc Link PMC2875539 Disease Relevance 0.17 Pain Relevance 0.06
We note that the levels of PRA and Ang II measured in our septic subjects are elevated nearly two-fold compared to outpatients with risk factors for vascular disease [33,34], arguing that the acute septic state contributes to RAS activation.
Gene_expression (levels) of Ang II associated with increased venous pressure under development
16) Confidence 0.30 Published 2010 Journal Crit Care Section Body Doc Link PMC2875539 Disease Relevance 1.06 Pain Relevance 0.03
The mRNA expressions of VEGF and Ang-2 in cultured HT-29 were determined by real-time quantitative reverse-transcription polymerase chain reaction.
Spec (determined) Gene_expression (expressions) of Ang-2 in HT-29
17) Confidence 0.28 Published 2007 Journal J. Huazhong Univ. Sci. Technol. Med. Sci. Section Abstract Doc Link 17828495 Disease Relevance 0.07 Pain Relevance 0.08
Similarly, the angiopoietins Ang1 and Ang2, and their cellular receptor Tie2, which are all widely expressed in RA synovitis, are regulated by both hypoxia and TNF-?
Gene_expression (expressed) of Ang2 associated with hypoxia, synovitis and rheumatoid arthritis
18) Confidence 0.19 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064874 Disease Relevance 1.19 Pain Relevance 0.32
Serum levels of angiopoietin (Ang)-1, Ang-2, vascular endothelial growth factor, placenta growth factor (PlGF), soluble tunica intima endothelial kinase 2 (sTIE2), erythropoietin (EPO) and endothelial activation markers (soluble vascular adhesion molecule-1, soluble intercellular adhesion molecule-1) were determined in controls, HbSS (n = 35) and HbSC (n = 23) patients.
Spec (determined) Gene_expression (levels) of Ang-2 in tunica intima associated with adhesions
19) Confidence 0.18 Published 2006 Journal Br. J. Haematol. Section Abstract Doc Link 16803577 Disease Relevance 0.55 Pain Relevance 0.06
Increased expression of tissue ACE has been found in the vasculature of subjects with hypertension and in the microvasculature throughout an atherosclerotic plaque, suggesting that the accumulation of ACE in the plaque contributes to increased local production of Ang II (Gibbons 1995; Diet et al 1996).
Gene_expression (production) of Ang II in plaque associated with atherosclerotic plaque and pressure and volume under development
20) Confidence 0.14 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.72 Pain Relevance 0.10

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