INT58774

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Context Info
Confidence 0.38
First Reported 1993
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 0.22
Pain Relevance 7.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (G2e3) Golgi apparatus (G2e3) intracellular (G2e3)
cytoplasm (G2e3)
Anatomy Link Frequency
plasma 3
G2e3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 83 100.00 Very High Very High Very High
Antinociceptive 13 100.00 Very High Very High Very High
antinociception 6 100.00 Very High Very High Very High
diclofenac 1 96.78 Very High Very High Very High
cINOD 5 96.28 Very High Very High Very High
intrathecal 1 93.72 High High
Dorsal horn 1 92.84 High High
c fibre 1 91.12 High High
agonist 1 89.88 High High
opioid receptor 1 89.32 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 2 76.28 Quite High
Disorders Of Creatine Metabolism 2 67.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gonadectomy only partially eliminated sex differences in morphine antinociception and plasma levels of M3G.
Negative_regulation (eliminated) of M3G in plasma associated with antinociception and morphine
1) Confidence 0.38 Published 2002 Journal Pain Section Abstract Doc Link 11790468 Disease Relevance 0 Pain Relevance 1.86
There was a slight, but not statistically significant, decrease in the antinociceptive effect of 5 micrograms morphine in the M3G-pretreated groups.
Negative_regulation (decrease) of M3G associated with antinociceptive and morphine
2) Confidence 0.10 Published 1993 Journal Pain Section Abstract Doc Link 8316391 Disease Relevance 0 Pain Relevance 1.19
Among the NSAIDs investigated (diclofenac, diflunisal, fenoprofen, flurbiprofen, ibuprofen, indomethacin, ketoprofen, mefenamic acid, niflumic acid, and sulindac), only niflumic acid and mefenamic acid inhibited E3G potently in all three species.
Negative_regulation (inhibited) of E3G associated with cinod and diclofenac
3) Confidence 0.09 Published 2008 Journal J Pharm Sci Section Abstract Doc Link 17763456 Disease Relevance 0.15 Pain Relevance 0.47
In this study, we investigate the effect of repeated exposures (10 daily i.p. injections) to heroin, morphine, cadmium (which has been previously shown to inhibit M3G formation in vitro), or heroin + cadmium on morphine glucuronidation both in vivo and ex vivo (i.e., microsomal preparation obtained from rats treated in vivo).
Negative_regulation (inhibit) of M3G associated with morphine
4) Confidence 0.08 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12975487 Disease Relevance 0 Pain Relevance 0.94
Repeated heroin (2.5, 5.0, and 10 mg/kg) increased plasma levels of M6G (which was undetectable in all other groups) and reduced those of M3G.
Negative_regulation (reduced) of M3G in plasma
5) Confidence 0.08 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12975487 Disease Relevance 0 Pain Relevance 0.93
In contrast, repeated morphine (10, 20, and 40 mg/kg) only slightly reduced M3G formation at the dose of 40 mg/kg.
Negative_regulation (reduced) of M3G associated with morphine
6) Confidence 0.07 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12975487 Disease Relevance 0 Pain Relevance 0.88
We have also shown that heroin-treated rats exhibit measurable levels of M6G (which is usually undetectable in this species) and reduced levels of M3G.
Negative_regulation (reduced) of M3G
7) Confidence 0.07 Published 2005 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 15986196 Disease Relevance 0 Pain Relevance 0.63
Accumulation of M3G in plasma of aged rats is probably due to diminished renal clearance of M3G in addition to a reduction in the biliary excretion of M3G.
Negative_regulation (reduction) of M3G in plasma
8) Confidence 0.04 Published 1997 Journal Pain Section Abstract Doc Link 9211481 Disease Relevance 0.07 Pain Relevance 0.84

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