INT58807

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Context Info
Confidence 0.06
First Reported 1993
Last Reported 1995
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc)
extracellular region (Pomc) molecular_function (Pomc) cell-cell signaling (Pomc)
Anatomy Link Frequency
POA 2
Pomc (Rattus norvegicus)
LH (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 11 100.00 Very High Very High Very High
Opioid 1 100.00 Very High Very High Very High
cytokine 1 99.44 Very High Very High Very High
Neuropeptide 6 97.12 Very High Very High Very High
excitatory amino acid 5 95.20 Very High Very High Very High
narcan 7 93.20 High High
agonist 2 84.16 Quite High
Intracerebroventricular 2 83.52 Quite High
GABAergic 2 75.00 Quite High
Endogenous opioid 1 69.60 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In rats, beta-endorphin (beta-END) and gamma-aminobutyric acid (GABA) suppress LH secretion by hypothalamic mechanisms involving the preoptic area (POA).
beta-endorphin Negative_regulation (suppress) of Localization (secretion) of LH in POA associated with gaba
1) Confidence 0.06 Published 1995 Journal Exp. Clin. Endocrinol. Diabetes Section Abstract Doc Link 8536061 Disease Relevance 0 Pain Relevance 0.47
The aim of this study was to test the hypothesis that inhibition of LH release by an opioid [beta-endorphin (beta END)], cytokine [interleukin-1 beta (IL-1 beta)], or tachykinin [neuropeptide-K (NPK)] is a result of diminished excitatory amino acid (EAA) signaling.
beta-endorphin Negative_regulation (inhibition) of Localization (release) of LH associated with neuropeptide, opioid, excitatory amino acid and cytokine
2) Confidence 0.05 Published 1993 Journal Endocrinology Section Abstract Doc Link 8319564 Disease Relevance 0 Pain Relevance 0.55

General Comments

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