INT58841

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Context Info
Confidence 0.75
First Reported 1993
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 33
Total Number 34
Disease Relevance 9.01
Pain Relevance 9.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (HTR2A) aging (HTR2A) plasma membrane (HTR2A)
response to stress (HTR2A) cytoplasm (HTR2A) signal transducer activity (HTR2A)
Anatomy Link Frequency
nucleus pulposus 2
coronary artery 2
dorsal root ganglion 2
spinal cord 1
brain 1
HTR2A (Homo sapiens)
HTR2A - T102C (1) HTR2A - C516T (1)
Pain Link Frequency Relevance Heat
Serotonin 196 100.00 Very High Very High Very High
agonist 97 100.00 Very High Very High Very High
antagonist 56 99.90 Very High Very High Very High
gABA 7 99.58 Very High Very High Very High
fluoxetine 65 98.92 Very High Very High Very High
substance P 3 98.92 Very High Very High Very High
cerebral cortex 1 98.84 Very High Very High Very High
antidepressant 91 98.80 Very High Very High Very High
Angina 2 98.72 Very High Very High Very High
sSRI 116 97.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 151 99.84 Very High Very High Very High
Anxiety Disorder 433 99.80 Very High Very High Very High
Spasticity 2 99.44 Very High Very High Very High
Angina 2 98.72 Very High Very High Very High
Cognitive Disorder 19 98.12 Very High Very High Very High
Obesity 12 97.76 Very High Very High Very High
Tremor 19 97.56 Very High Very High Very High
Appetite Loss 7 97.50 Very High Very High Very High
Disease 223 96.70 Very High Very High Very High
Schizophrenia 84 96.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The antidepressant, mianserin, is a serotonin receptor (5-HT2) antagonist and produces down-regulation of 5-HT2 and 5-HT1c receptors in the cerebral cortex of rats.
Gene_expression (produces) of 5-HT2 in cerebral cortex associated with antidepressant, antagonist, cerebral cortex and serotonin
1) Confidence 0.75 Published 1993 Journal Life Sci. Section Abstract Doc Link 8326822 Disease Relevance 0 Pain Relevance 0.36
5-Hydroxytryptamine-induced contraction of human temporal arteries coexpressing 5-HT2A receptors and wild-type or variant (Phe124Cys) 5-HT1B receptors: increased contribution of 5-HT1B receptors to the total contractile amplitude in arteries from Phe124Cys heterozygous individuals.
Gene_expression (coexpressing) of 5-HT2A
2) Confidence 0.75 Published 2006 Journal Pharmacogenet. Genomics Section Title Doc Link 16847428 Disease Relevance 0 Pain Relevance 0.21
The rise in oestrogen concentration is followed by an increase in the 5HT2A receptor expression in brain areas responsible for mood, emotion, cognition and neuroendocrine regulation.
Gene_expression (expression) of 5HT2A in brain associated with cognitive disorder
3) Confidence 0.75 Published 2004 Journal Neuropsychopharmacol Hung Section Abstract Doc Link 15816306 Disease Relevance 0.67 Pain Relevance 0.40
Isolated microvessels and capillaries consistently expressed messages for the h5-HT1B, h5-HT1D, 5-HT1F, 5-HT2A but not 5-HT7 receptors.
Gene_expression (expressed) of 5-HT2A
4) Confidence 0.75 Published 1999 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 10458598 Disease Relevance 0 Pain Relevance 0
Expression of 5-HT2A receptors in the left L5 DRG was examined by immunohistochemical and immunoblotting analyses in the control and NP groups.
Spec (examined) Gene_expression (Expression) of 5-HT2A in DRG
5) Confidence 0.75 Published 2008 Journal Spine Section Body Doc Link 18496345 Disease Relevance 0.06 Pain Relevance 0
CONCLUSION: Exogenous 5-HT to the nerve root induced pain-related behavior with short-lasting effects compared with the nucleus pulposus application. 5-HIAA content in plasma and expression of 5-HT2A receptors in DRG neurons increased early time points after the nucleus pulposus application.
Gene_expression (expression) of 5-HT2A in nucleus pulposus
6) Confidence 0.75 Published 2008 Journal Spine Section Body Doc Link 18496345 Disease Relevance 0 Pain Relevance 0
Furthermore, we detected gene expression of 5-HT1Dbeta and 5-HT2A receptors in spastic coronary artery using RNase protection assay.
Gene_expression (expression) of 5-HT2A in coronary artery associated with spasticity
7) Confidence 0.75 Published 1998 Journal Chest Section Abstract Doc Link 9440599 Disease Relevance 0.45 Pain Relevance 0.49
The expression of 5-HT2A receptors was enhanced in a time-dependent manner by nucleus pulposus.
Gene_expression (expression) of 5-HT2A in nucleus pulposus
8) Confidence 0.75 Published 2008 Journal Spine Section Body Doc Link 18496345 Disease Relevance 0 Pain Relevance 0
However, this inhibition requires the functional elimination of substance P/gamma-aminobutyric acid (SP/GABA) interneurons which express 5-HT2A receptors as shown by in situ hybridisation histochemistry.
Gene_expression (express) of 5-HT2A in interneurons associated with gaba and substance p
9) Confidence 0.75 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8938661 Disease Relevance 0.06 Pain Relevance 0.24
OBJECTIVE: We evaluated the effects of exogenous 5-HT applied on the nerve root on pain-related behavior, the release of endogenous 5-HT in plasma, and the expression of 5-HT2A receptors in dorsal root ganglion (DRG) in a rat LDH model.
Gene_expression (expression) of 5-HT2A in dorsal root ganglion
10) Confidence 0.75 Published 2008 Journal Spine Section Body Doc Link 18496345 Disease Relevance 0.09 Pain Relevance 0
METHODS: Rings of arteries, coexpressing 5-HT1B and 5-HT2A receptors, from 98 patients undergoing neurosurgery were set up to measure contraction.
Gene_expression (coexpressing) of 5-HT2A
11) Confidence 0.75 Published 2006 Journal Pharmacogenet. Genomics Section Body Doc Link 16847428 Disease Relevance 0 Pain Relevance 0
Mirtazapine (RemeronĀ®), a novel antidepressant that enhances noradrenergic and serotonergic transmission and acts as a presynaptic alpha-2, 5HT2, and 5HT3 receptor antagonist, has been reported to improve rest tremor and levodopa-induced dyskinesia (Pact and Giduz 1999).
Gene_expression (presynaptic) of 5HT2 associated with tremor, antidepressant, antagonist and dyskinesias
12) Confidence 0.65 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536542 Disease Relevance 1.22 Pain Relevance 0.34
The activation of postsynaptic 5-HT2A and 5-HT2C receptors may be important in the improvement of OCD symptoms after treatment with an SSRI.45 Studies in OCD patients showed blunted prolactin and cortisol responses to 5-HT2 receptor agonists.46 Enoch et al.47 recruited and genotyped 101 Caucasian OCD patients (48 females, 53 males) and 138 control subjects (77 females, 61 males) and found that the -1438A allele frequency was higher only in female OCD patients and not in male patients.
Gene_expression (receptors) of 5-HT2A associated with anxiety disorder, agonist and ssri
13) Confidence 0.65 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687723 Disease Relevance 0.87 Pain Relevance 0.19
These targets were subsequently classified in the 5-HT1, 5-HT2, and 5-HT3 families using specific and distinguishing agonism and especially antagonism by drugs like Bemestron and Tropisetron (for the 5-HT3 family).
Gene_expression (classified) of 5-HT2
14) Confidence 0.65 Published 2010 Journal Biochemistry Section Body Doc Link PMC2994275 Disease Relevance 0.06 Pain Relevance 0.25
Although they did not find any significant differences in the frequencies of allele and genotype for the T102C 5-HT2A gene polymorphism, they found a significant association between C516T 5-HT2A gene polymorphism and OCD.
Gene_expression (polymorphism) of 5-HT2A (C516T) associated with anxiety disorder
15) Confidence 0.65 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687723 Disease Relevance 0.97 Pain Relevance 0.12
Moderate affinity was also found for D4, 5-HT2C, 5-HT7, ?
Gene_expression (found) of 5-HT2
16) Confidence 0.65 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938284 Disease Relevance 0.48 Pain Relevance 0.14
The serotonergic pathway acting on 5-HT2A receptors may be obligatory for GRF-mediated stimulation and is sensitive to inhibition by Cypro.
Gene_expression (acting) of 5-HT2A
17) Confidence 0.65 Published 1996 Journal Psychoneuroendocrinology Section Abstract Doc Link 8774064 Disease Relevance 0.06 Pain Relevance 0.72
All tissues expressed 5-HT1Dbeta, 5-HT2A, 5-HT2B, 5-HT4 and 5-HT7 mRNAs.
Gene_expression (expressed) of 5-HT2A
18) Confidence 0.65 Published 1996 Journal Eur. J. Neurosci. Section Abstract Doc Link 8743744 Disease Relevance 0.44 Pain Relevance 0.94
Quantitative autoradiography with selective radioligands was used to establish the respective distribution of serotonin 5-HT1A, 5-HT1D, 5-HT2A and 5-HT3 receptors at the cervical, thoracic and lumbar levels of the spinal cord from subjects who died at 81-94 years.
Gene_expression (distribution) of 5-HT2A in spinal cord associated with serotonin and spinal cord
19) Confidence 0.65 Published 1996 Journal J. Chem. Neuroanat. Section Abstract Doc Link 8841890 Disease Relevance 0 Pain Relevance 0.27
Frontal 5-HT2A receptors studied in depressive patients during chronic treatment by selective serotonin reuptake inhibitors.
Gene_expression (studied) of 5-HT2A associated with depression and ssri
20) Confidence 0.65 Published 1997 Journal Psychopharmacology (Berl.) Section Title Doc Link 9335087 Disease Relevance 0.28 Pain Relevance 0.22

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