INT58843

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Context Info
Confidence 0.39
First Reported 1993
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 10
Disease Relevance 1.09
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sars) ligase activity (Sars) cytoplasm (Sars)
Anatomy Link Frequency
dorsal 1
neurons 1
lung 1
Sars (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 255 99.28 Very High Very High Very High
c fibre 9 99.00 Very High Very High Very High
excitatory amino acid 33 98.76 Very High Very High Very High
Spinal cord 1 98.68 Very High Very High Very High
medulla 58 97.76 Very High Very High Very High
antagonist 33 90.52 High High
Central nervous system 2 88.64 High High
qutenza 7 86.40 High High
vagus nerve 52 81.40 Quite High
lidocaine 12 79.24 Quite High
Disease Link Frequency Relevance Heat
Asthma 5 90.80 High High
Cough 6 90.40 High High
Paralysis 1 78.52 Quite High
Hypoxia 10 68.32 Quite High
INFLAMMATION 4 65.48 Quite High
Apnoea 27 60.40 Quite High
Hyperoxia 2 56.00 Quite High
Hypercapnia 8 54.56 Quite High
Dyspnea 15 5.00 Very Low Very Low Very Low
Overdose 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ammonia increased tonic activity of SARs (n=10, P<0.0001), with complex changes in ventilator-related activity.
Positive_regulation (increased) of SARs
1) Confidence 0.39 Published 2007 Journal Auton Neurosci Section Abstract Doc Link 17169618 Disease Relevance 0.14 Pain Relevance 0.07
Several studies have demonstrated that activation of the pump cells by the SARs input is at least partly mediated by the action of glutamate at excitatory amino acid (EAA) receptors (most likely of AMPA type) (Bonham et al. 1993; Zhang & Mifflin, 1995; Miyazaki et al. 1999; Kubin et al. 2006).
Positive_regulation (mediated) of SARs associated with glutamate and excitatory amino acid
2) Confidence 0.32 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538935 Disease Relevance 0 Pain Relevance 0.18
ATP induces an increase in discharge of the NTS second order relay neurones that receive SARs input
Positive_regulation (receive) of SARs
3) Confidence 0.32 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538935 Disease Relevance 0 Pain Relevance 0.58
Activation of SARs strongly potentiates the ER from the vocal folds, by a reflex mechanism, and inhibition of SARs weakens the ER.
Positive_regulation (Activation) of SARs
4) Confidence 0.30 Published 2006 Journal Respir Physiol Neurobiol Section Abstract Doc Link 16584927 Disease Relevance 0.45 Pain Relevance 0.29
Release of ATP and glutamate in the nucleus tractus solitarii mediate pulmonary stretch receptor (Breuer–Hering) reflex pathway

The Breuer–Hering inflation reflex is initiated by activation of the slowly adapting pulmonary stretch receptor afferents (SARs), which monosynaptically activate second-order relay neurones in the dorsal medullary nucleus of the solitary tract (NTS).

Positive_regulation (activation) of SARs in dorsal associated with glutamate
5) Confidence 0.30 Published 2008 Journal The Journal of Physiology Section Title Doc Link PMC2538935 Disease Relevance 0.06 Pain Relevance 0.27
However, stimulation of SARs by lung inflation has an inconsistent effect on the CR.
Positive_regulation (stimulation) of SARs in lung
6) Confidence 0.28 Published 2006 Journal Respir Physiol Neurobiol Section Abstract Doc Link 16584927 Disease Relevance 0.28 Pain Relevance 0.27
Histamine-induced ETIA originates from stimulation of RARs, and is inhibited by stimulation of SARs.
Positive_regulation (stimulation) of SARs
7) Confidence 0.07 Published 1995 Journal Eur. Respir. J. Section Abstract Doc Link 8666106 Disease Relevance 0.09 Pain Relevance 0.10
The relative ease of selective activation of SARs, and to a lesser extent RARs, has allowed for more complete physiological and morphological characterization of the second and higher order neurons in these pathways than for C fibers.
Positive_regulation (activation) of SARs in neurons
8) Confidence 0.07 Published 2006 Journal J. Appl. Physiol. Section Abstract Doc Link 16645192 Disease Relevance 0 Pain Relevance 0.13
Histamine was used to stimulate RARs, and this was combined with continuous positive airway pressure (CPAP) to further stimulate SARs.
Positive_regulation (stimulate) of SARs
9) Confidence 0.05 Published 1995 Journal Eur. Respir. J. Section Abstract Doc Link 8666106 Disease Relevance 0.07 Pain Relevance 0.08
Our data strongly indicate that stimulation of SARs suppresses TIA, whereas C-fiber endings are not involved in TIA at all.
Positive_regulation (stimulation) of SARs associated with c fibre
10) Confidence 0.04 Published 1993 Journal Respir Physiol Section Abstract Doc Link 8327788 Disease Relevance 0 Pain Relevance 0.17

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