INT58884

Context Info Confidence 0.75 First Reported 1993 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 6 Disease Relevance 4.53 Pain Relevance 1.43

transport (SLC25A5) mitochondrion (SLC25A5) small molecule metabolic process (SLC25A5) chromosome segregation (SLC25A5) transmembrane transport (SLC25A5)

Anatomy Link Frequency ganglia 2 1A2 1 SLC25A5 (Homo sapiens)

Pain Link Frequency Relevance Heat Paracetamol 7 96.84 addiction 12 95.56 dexamethasone 3 91.32 Rsd 6 79.68 ganglionectomy 8 75.12 Pain 5 74.08 Analgesic 1 51.84 cytokine 3 5.00 imagery 3 5.00

Disease Link Frequency Relevance Heat Renal Cancer 165 99.44 Pox Virus Infection 1 99.00 Cancer 303 92.36 Hypoxia 21 91.84 Pneumothorax 2 85.64 Intraoperative Complications 2 83.28 Complex Regional Pain Syndromes 6 79.68 Skin Appendage Disease 6 77.56 Lung Cancer 6 75.36 Pain 5 74.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Human P450s (2A6, 2E1, 1A2, 3A4, 3A5, 3A3, 2D6, 2F1, 2C8, 2B6, and 2C9) expressed in Hep G2 cells using a vaccinia virus expression system were each tested for APAP metabolism.

Gene_expression (expressed) of 2F1 in 1A2 associated with paracetamol and pox virus infection

1) Confidence 0.75 Published 1993 Journal Chem. Res. Toxicol. Section Abstract Doc Link 8374050 Disease Relevance 0.10 Pain Relevance 0.65

The T-2 and T-3 ganglia were grasped with forceps and excised.

Gene_expression (grasped) of T-3 in ganglia

2) Confidence 0.65 Published 1993 Journal J. Neurosurg. Section Abstract Doc Link 8331407 Disease Relevance 0.51 Pain Relevance 0.32

The T-2 and T-3 ganglia were grasped with forceps and excised.

Gene_expression (excised) of T-3 in ganglia

3) Confidence 0.65 Published 1993 Journal J. Neurosurg. Section Abstract Doc Link 8331407 Disease Relevance 0.52 Pain Relevance 0.33

These genes include SLC25A5 (ANT2, down), which catalyzes the exchange of ATP for ADP across the mitochondrial membrane, thus playing an important role in oxidative phosphorylation.

Gene_expression (include) of SLC25A5

4) Confidence 0.49 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.14 Pain Relevance 0.04

These genes include SLC25A5 (ANT2, down), which catalyzes the exchange of ATP for ADP across the mitochondrial membrane, thus playing an important role in oxidative phosphorylation.

Gene_expression (include) of ANT2

5) Confidence 0.49 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.14 Pain Relevance 0.04

Renal carcinomas were found to have reduced levels of ANT2 and other oxidative phosphorylation genes (Heddi et al. 1996) in line with the argument that the loss of cell dependence on oxidative metabolism is an important factor in the development of tumors under hypoxic conditions (Chevrollier et al. 2005).

Gene_expression (levels) of ANT2 associated with addiction, hypoxia, cancer and renal cancer

6) Confidence 0.44 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.11 Pain Relevance 0.05

General Comments

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