INT58896

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Context Info
Confidence 0.81
First Reported 1993
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 35
Total Number 39
Disease Relevance 4.57
Pain Relevance 14.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Adcyap1) signal transduction (Adcyap1) extracellular space (Adcyap1)
extracellular region (Adcyap1)
Anatomy Link Frequency
pituitary 11
hippocampus 3
ear 3
spinal cord 2
outflow 1
Adcyap1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 78 100.00 Very High Very High Very High
Cholecystokinin 5 100.00 Very High Very High Very High
Neurotransmitter 4 100.00 Very High Very High Very High
Enkephalin 4 100.00 Very High Very High Very High
Dynorphin 1 100.00 Very High Very High Very High
substance P 30 99.92 Very High Very High Very High
qutenza 78 99.84 Very High Very High Very High
Calcitonin gene-related peptide 81 99.76 Very High Very High Very High
anesthesia 9 99.48 Very High Very High Very High
Somatostatin 54 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 13 100.00 Very High Very High Very High
Encephalitis 14 99.16 Very High Very High Very High
Migraine Disorders 2 98.80 Very High Very High Very High
Heart Rate Under Development 3 97.88 Very High Very High Very High
INFLAMMATION 50 97.52 Very High Very High Very High
Pressure And Volume Under Development 12 96.64 Very High Very High Very High
Immune System Diseases 2 96.04 Very High Very High Very High
Neurogenic Inflammation 18 95.36 Very High Very High Very High
Ganglion Cysts 17 86.64 High High
Apoptosis 8 79.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is concluded that centrally administered PACAP may have a regulatory effect on gastric secretion through PACAP receptors and the vagal pathway.
Localization (secretion) of PACAP
1) Confidence 0.81 Published 1997 Journal Dig. Dis. Sci. Section Abstract Doc Link 9440635 Disease Relevance 0 Pain Relevance 0.07
PACAP released from these fibres could alone or in concert with vasoactive intestinal polypeptide play a role in neuroregulation of female reproductive organs acting directly on the musculature and vasculature.
Localization (released) of PACAP in reproductive organs
2) Confidence 0.80 Published 1996 Journal Neuroscience Section Abstract Doc Link 8809823 Disease Relevance 0.19 Pain Relevance 0.15
In some fibres, which seem to originate in the local paracervical ganglia, PACAP was co-localized with vasoactive intestinal polypeptide.
Localization (localized) of PACAP in ganglia
3) Confidence 0.80 Published 1996 Journal Neuroscience Section Abstract Doc Link 8809823 Disease Relevance 0.19 Pain Relevance 0.16
Using double immunohistochemistry, with VIP as a marker for intrinsic innervation and calcitonin-gene related peptide (CGRP) as a marker for mainly extrinsic innervation, the distribution and localization of PACAP were studied in the rat pancreas.
Localization (localization) of PACAP in pancreas
4) Confidence 0.80 Published 2000 Journal Cell Tissue Res. Section Abstract Doc Link 10654070 Disease Relevance 0.09 Pain Relevance 0.10
In view of the presence of PACAP-immunoreactive nerve fibres in the superficial layers of the dorsal horn and the expression of PACAP in the small sized neurons in the dorsal root ganglia, the findings suggest that PACAP is released into the artificial cerebrospinal fluid from C-fibres in the spinal cord.
Localization (released) of PACAP in cerebrospinal fluid associated with c fibre, dorsal horn and spinal cord
5) Confidence 0.80 Published 1997 Journal Regul. Pept. Section Abstract Doc Link 9178350 Disease Relevance 0 Pain Relevance 0.73
PACAPs stimulate duodenal bicarbonate secretion at PACAP receptors in the rat.
Localization (secretion) of PACAP associated with neuropeptide
6) Confidence 0.80 Published 1997 Journal Am. J. Physiol. Section Title Doc Link 9124587 Disease Relevance 0 Pain Relevance 0.27
In the pituitary gland, the release of PACAP depended on the stage of the estrous cycle and on the time of day the animals were sacrificed.
Localization (release) of PACAP in pituitary gland
7) Confidence 0.79 Published 2003 Journal J. Mol. Neurosci. Section Abstract Doc Link 12794308 Disease Relevance 0 Pain Relevance 0.09
In the present study, we investigated the effects of VIP and PACAP on the release of ACh from the rat hippocampus.
Localization (release) of PACAP in hippocampus associated with hippocampus
8) Confidence 0.74 Published 1993 Journal Brain Res. Section Abstract Doc Link 8334515 Disease Relevance 0 Pain Relevance 0.28
Effects of vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) on the spontaneous release of acetylcholine from the rat hippocampus by brain microdialysis.
Localization (release) of PACAP in hippocampus associated with neuropeptide and hippocampus
9) Confidence 0.74 Published 1993 Journal Brain Res. Section Title Doc Link 8334515 Disease Relevance 0 Pain Relevance 0.31
It is concluded that centrally administered PACAP may have a regulatory effect on gastric secretion through PACAP receptors and the vagal pathway.
Localization (secretion) of PACAP
10) Confidence 0.71 Published 1997 Journal Dig. Dis. Sci. Section Abstract Doc Link 9440635 Disease Relevance 0 Pain Relevance 0.08
Central administration of PACAP stimulates gastric secretion mediated through the vagal pathway in anesthetized rats.
Localization (secretion) of PACAP associated with anesthesia
11) Confidence 0.71 Published 1997 Journal Dig. Dis. Sci. Section Title Doc Link 9440635 Disease Relevance 0 Pain Relevance 0.33
In this study, we examined the effects of centrally administered PACAP38 and PACAP27 on gastric secretion in anesthetized rats.
Localization (secretion) of PACAP27
12) Confidence 0.71 Published 1997 Journal Dig. Dis. Sci. Section Abstract Doc Link 9440635 Disease Relevance 0 Pain Relevance 0.08
In this study, we examined the effects of centrally administered PACAP38 and PACAP27 on gastric secretion in anesthetized rats.
Localization (secretion) of PACAP38
13) Confidence 0.71 Published 1997 Journal Dig. Dis. Sci. Section Abstract Doc Link 9440635 Disease Relevance 0 Pain Relevance 0.08
Capsaicin-evoked release of pituitary adenylate cyclase activating peptide (PACAP)-like immunoreactivity (LI) from rat spinal cord was examined in vivo.
Localization (release) of pituitary adenylate cyclase activating peptide in pituitary associated with qutenza and spinal cord
14) Confidence 0.70 Published 1997 Journal Regul. Pept. Section Abstract Doc Link 9178350 Disease Relevance 0 Pain Relevance 0.50
Capsaicin-evoked release of pituitary adenylate cyclase activating peptide (PACAP) and calcitonin gene-related peptide (CGRP) from rat spinal cord in vivo.
Localization (release) of pituitary adenylate cyclase activating peptide in spinal cord associated with qutenza, spinal cord and calcitonin gene-related peptide
15) Confidence 0.70 Published 1997 Journal Regul. Pept. Section Title Doc Link 9178350 Disease Relevance 0 Pain Relevance 0.87
Capsaicin-evoked release of pituitary adenylate cyclase activating peptide (PACAP)-like immunoreactivity (LI) from rat spinal cord was examined in vivo.
Localization (release) of PACAP in pituitary associated with qutenza and spinal cord
16) Confidence 0.70 Published 1997 Journal Regul. Pept. Section Abstract Doc Link 9178350 Disease Relevance 0 Pain Relevance 0.50
Capsaicin-evoked release of pituitary adenylate cyclase activating peptide (PACAP) and calcitonin gene-related peptide (CGRP) from rat spinal cord in vivo.
Localization (release) of PACAP in spinal cord associated with qutenza, spinal cord and calcitonin gene-related peptide
17) Confidence 0.70 Published 1997 Journal Regul. Pept. Section Title Doc Link 9178350 Disease Relevance 0 Pain Relevance 0.88
Its activation releases a mixture of signalling molecules including vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP), which subsequently stimulate VPAC(1), VPAC(2) and PAC(1) receptors.
Localization (releases) of PACAP in pituitary associated with heart rate under development
18) Confidence 0.66 Published 2009 Journal Cephalalgia Section Abstract Doc Link 19220306 Disease Relevance 0.28 Pain Relevance 0.22
These results suggest that 1) PACAP is a potent stimulator of HCO(3)- secretion in the duodenum, but not in the stomach, and may be involved in the peripheral regulation of duodenal HCO(3)- secretion, 2) this action is mediated by adenosine 3',5'-cyclic monophosphate, probably through PACAP and VIP receptors, and 3) adenosine 3',5'-cyclic monophosphate is a mediator in duodenal, but not in gastric, HCO(3)- secretion.
Localization (secretion) of PACAP in stomach associated with adenocard
19) Confidence 0.65 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9124587 Disease Relevance 0 Pain Relevance 0.27
Pituitary adenylate cyclase activating polypeptides (PACAP) stimulate duodenal HCO3- secretion in the rat.
Localization (secretion) of PACAP in Pituitary
20) Confidence 0.65 Published 1998 Journal Pharmacol. Res. Section Abstract Doc Link 9990657 Disease Relevance 0 Pain Relevance 0.08

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