INT58897

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Context Info
Confidence 0.45
First Reported 1993
Last Reported 2010
Negated 0
Speculated 4
Reported most in Abstract
Documents 4
Total Number 7
Disease Relevance 1.82
Pain Relevance 3.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Adcyap1) signal transduction (Adcyap1) extracellular space (Adcyap1)
extracellular region (Adcyap1)
Anatomy Link Frequency
ear 6
brain 2
pituitary 2
pituitary gland 2
hippocampus 2
Adcyap1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 32 100.00 Very High Very High Very High
Neuropeptide 14 100.00 Very High Very High Very High
neuropeptide release 9 99.52 Very High Very High Very High
Hippocampus 14 98.76 Very High Very High Very High
Somatostatin 12 96.16 Very High Very High Very High
qutenza 24 93.20 High High
Endogenous opioid 1 92.68 High High
Calcitonin gene-related peptide 15 91.84 High High
substance P 15 90.12 High High
tetrodotoxin 2 53.68 Quite High
Disease Link Frequency Relevance Heat
Encephalitis 7 100.00 Very High Very High Very High
Immune System Diseases 1 98.20 Very High Very High Very High
INFLAMMATION 23 97.52 Very High Very High Very High
Pressure And Volume Under Development 6 97.32 Very High Very High Very High
Neurogenic Inflammation 9 95.36 Very High Very High Very High
Death 18 78.44 Quite High
Disease 4 58.32 Quite High
Neurological Disease 1 54.48 Quite High
Neurodegenerative Disease 5 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the pituitary gland, the release of PACAP depended on the stage of the estrous cycle and on the time of day the animals were sacrificed.
Regulation (depended) of Localization (release) of PACAP in pituitary gland
1) Confidence 0.45 Published 2003 Journal J. Mol. Neurosci. Section Abstract Doc Link 12794308 Disease Relevance 0 Pain Relevance 0.09
Effects of vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) on the spontaneous release of acetylcholine from the rat hippocampus by brain microdialysis.
Regulation (Effects) of in pituitary Localization (release) of PACAP in hippocampus associated with neuropeptide and hippocampus
2) Confidence 0.44 Published 1993 Journal Brain Res. Section Title Doc Link 8334515 Disease Relevance 0 Pain Relevance 0.31
Effects of vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) on the spontaneous release of acetylcholine from the rat hippocampus by brain microdialysis.
Regulation (Effects) of in pituitary Localization (release) of activating polypeptide in hippocampus associated with neuropeptide and hippocampus
3) Confidence 0.39 Published 1993 Journal Brain Res. Section Title Doc Link 8334515 Disease Relevance 0 Pain Relevance 0.31
The aim of the present study was to investigate the release of pituitary adenylate cyclase activating polypeptide-38 (PACAP-38) and its effects on sensory neuropeptide release in vitro and acute neurogenic ear swelling in vivo.
Spec (investigate) Regulation (effects) of Spec (investigate) Localization (release) of PACAP-38 in ear associated with pressure and volume under development and neuropeptide release
4) Confidence 0.27 Published 2006 Journal Neuroscience Section Abstract Doc Link 16938409 Disease Relevance 0.44 Pain Relevance 0.86
The aim of the present study was to investigate the release of pituitary adenylate cyclase activating polypeptide-38 (PACAP-38) and its effects on sensory neuropeptide release in vitro and acute neurogenic ear swelling in vivo.
Spec (investigate) Regulation (effects) of Spec (investigate) Localization (release) of pituitary adenylate cyclase activating polypeptide-38 in ear associated with pressure and volume under development and neuropeptide release
5) Confidence 0.27 Published 2006 Journal Neuroscience Section Abstract Doc Link 16938409 Disease Relevance 0.44 Pain Relevance 0.86
The aim of the present study was to investigate the release of pituitary adenylate cyclase activating polypeptide-38 (PACAP-38) and its effects on sensory neuropeptide release in vitro and acute neurogenic ear swelling in vivo.
Spec (investigate) Regulation (effects) of Spec (investigate) Localization (release) of pituitary adenylate cyclase activating polypeptide-38 in ear associated with pressure and volume under development and neuropeptide release
6) Confidence 0.27 Published 2006 Journal Neuroscience Section Abstract Doc Link 16938409 Disease Relevance 0.44 Pain Relevance 0.86
released from immune cells and PACAP is of importance in brain inflammation and may affect the regeneration and recruitment of NPCs in immune diseases.
Spec (may) Regulation (affect) of Localization (released) of PACAP in brain associated with inflammation, encephalitis and immune system diseases
7) Confidence 0.19 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2885411 Disease Relevance 0.50 Pain Relevance 0.19

General Comments

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